Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Pavel, Kovarik"'
Autor:
Sara Scinicariello, Adrian Soderholm, Markus Schäfer, Alexandra Shulkina, Irene Schwartz, Kathrin Hacker, Rebeca Gogova, Robert Kalis, Kimon Froussios, Valentina Budroni, Annika Bestehorn, Tim Clausen, Pavel Kovarik, Johannes Zuber, Gijs A Versteeg
Publikováno v:
eLife, Vol 12 (2023)
Tristetraprolin (TTP) is a critical negative immune regulator. It binds AU-rich elements in the untranslated-regions of many mRNAs encoding pro-inflammatory mediators, thereby accelerating their decay. A key but poorly understood mechanism of TTP reg
Externí odkaz:
https://doaj.org/article/274f7c4e08f04208b5450742450a2db2
Autor:
Carlos Gomez-Diaz, Gustav Jonsson, Katrin Schodl, Luiza Deszcz, Annika Bestehorn, Kevin Eislmayr, Jorge Almagro, Anoop Kavirayani, Mayu Seida, Lilian M. Fennell, Astrid Hagelkruys, Pavel Kovarik, Josef M. Penninger, Fumiyo Ikeda
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103241- (2021)
Summary: The Linear Ubiquitin Chain Assembly Complex (LUBAC), composed of HOIP, HOIL-1L, and SHARPIN, promotes tumor necrosis factor (TNF)-dependent NF-κB signaling in diverse cell types. HOIL-1L contains an Npl4 Zinc Finger (NZF) domain that specif
Externí odkaz:
https://doaj.org/article/50f34cedbe9040a0b591ac5680f24ec3
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Regulated changes in mRNA stability are critical drivers of gene expression adaptations to immunological cues. mRNA stability is controlled mainly by RNA-binding proteins (RBPs) which can directly cleave mRNA but more often act as adaptors for the re
Externí odkaz:
https://doaj.org/article/09cb7cace280476b856c6ae0c80049d0
Autor:
Lucy Sneezum, Kevin Eislmayr, Helene Dworak, Vitaly Sedlyarov, Anita Le Heron, Florian Ebner, Irmgard Fischer, Yoichiro Iwakura, Pavel Kovarik
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The bioavailability of the major pro-inflammatory cytokines IL-1α and IL-1β is tightly controlled by transcription and post-translational processing to prevent hyperinflammation. The role of mRNA decay in maintenance of physiological IL-1 amounts r
Externí odkaz:
https://doaj.org/article/e77c6edfb5a14fc29a5f224721f77f84
Autor:
Anna Hafner, Ulrike Kolbe, Isabel Freund, Virginia Castiglia, Pavel Kovarik, Tanja Poth, Franziska Herster, Markus A. Weigand, Alexander N. R. Weber, Alexander H. Dalpke, Tatjana Eigenbrod
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Streptococcus pyogenes is a major human pathogen causing a variety of diseases ranging from common pharyngitis to life-threatening soft tissue infections and sepsis. Microbial nucleic acids, especially bacterial RNA, have recently been recognized as
Externí odkaz:
https://doaj.org/article/dcde18935f0e4cda96fa1835e3401b9a
Autor:
Matthias Parrini, Katrin Meissl, Mojoyinola Joanna Ola, Therese Lederer, Ana Puga, Sebastian Wienerroither, Pavel Kovarik, Thomas Decker, Mathias Müller, Birgit Strobl
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
STAT1 has a key role in the regulation of innate and adaptive immunity by inducing transcriptional changes in response to cytokines, such as all types of interferons (IFN). STAT1 exist as two splice isoforms, which differ in regard to the C-terminal
Externí odkaz:
https://doaj.org/article/0759af4a4d504d66b6cb892599b4a810
Autor:
Christoph Gasche, Nicole Meisner-Kober, Guglielmo Roma, Martin Beibel, Vineeta Khare, Pavel Kovarik, Orest Kuzyk, Alexander Loy, Kyle Dammann, Rayko Evstatiev, Vitaly Sedlyarov, Florian Ebner, Sabin Bhuju, Ildiko Mesteri, Katharina Passecker, David Berry, Michaela Lang
CD8+ cytotoxic T-lymphocytes, NKp46+ natural killer cells and F4/80+ macrophages in tumors of AOM/DSS and APCMin mice. Analysis of cytokines secreted by small intestinal organoids upon MS-444 treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bd3e10c0ddc740c6690074712f13d5
https://doi.org/10.1158/0008-5472.22410987
https://doi.org/10.1158/0008-5472.22410987
Autor:
Christoph Gasche, Nicole Meisner-Kober, Guglielmo Roma, Martin Beibel, Vineeta Khare, Pavel Kovarik, Orest Kuzyk, Alexander Loy, Kyle Dammann, Rayko Evstatiev, Vitaly Sedlyarov, Florian Ebner, Sabin Bhuju, Ildiko Mesteri, Katharina Passecker, David Berry, Michaela Lang
MS-444 restores splenic lymphoid follicles and decreases spleen weight in APCMin mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae1cb82193dbe6290cc92bce2f297300
https://doi.org/10.1158/0008-5472.22410984
https://doi.org/10.1158/0008-5472.22410984
Autor:
Christoph Gasche, Nicole Meisner-Kober, Guglielmo Roma, Martin Beibel, Vineeta Khare, Pavel Kovarik, Orest Kuzyk, Alexander Loy, Kyle Dammann, Rayko Evstatiev, Vitaly Sedlyarov, Florian Ebner, Sabin Bhuju, Ildiko Mesteri, Katharina Passecker, David Berry, Michaela Lang
HuR is an RNA-binding protein implicated in immune homeostasis and various cancers, including colorectal cancer. HuR binding to AU-rich elements within the 3′ untranslated region of mRNAs encoding oncogenes, growth factors, and various cytokines le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c298f217fbe792ebb9434787d0395c6
https://doi.org/10.1158/0008-5472.c.6508122
https://doi.org/10.1158/0008-5472.c.6508122
Autor:
Christoph Gasche, Nicole Meisner-Kober, Guglielmo Roma, Martin Beibel, Vineeta Khare, Pavel Kovarik, Orest Kuzyk, Alexander Loy, Kyle Dammann, Rayko Evstatiev, Vitaly Sedlyarov, Florian Ebner, Sabin Bhuju, Ildiko Mesteri, Katharina Passecker, David Berry, Michaela Lang
Alpha diversity in feces of AOM/DSS and APCMin upon MS-444 treatment and indicator OTUs in AOM/DSS mouse feces.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833d817d5a438ee68d29e1ddb93d8af1
https://doi.org/10.1158/0008-5472.22410981.v1
https://doi.org/10.1158/0008-5472.22410981.v1