Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Pavel, Bárta"'
Autor:
Martin Krátký, Klára Konečná, Ondřej Janďourek, Adéla Diepoltová, Pavlína Vávrová, Barbora Voxová, Marcela Vejsová, Pavel Bárta, Szilvia Bősze
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT In this study, we have focused on a multiparametric microbiological analysis of the antistaphylococcal action of the iodinated imine BH77, designed as an analogue of rafoxanide. Its antibacterial activity against five reference strains and e
Externí odkaz:
https://doaj.org/article/cf270161215c4616bea6e52739e204f5
Autor:
Klára Konečná, Adéla Diepoltová, Pavlína Holmanová, Ondřej Jand’ourek, Marcela Vejsová, Barbora Voxová, Pavel Bárta, Jana Maixnerová, František Trejtnar, Marta Kučerová-Chlupáčová
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The greatest threat and medicinal impact within gram-positive pathogens are posed by two bacterial genera, Staphylococcus and Enterococcus. Chalcones have a wide range of biological activities and are recognized as effective templates in medicinal ch
Externí odkaz:
https://doaj.org/article/4da402bc3a974b44916136f26d267479
Autor:
Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Adéla Diepoltová, Ondřej Janďourek, Pavel Bárta, Klára Konečná, Pavla Paterová, Vít Šesták, Jan Zitko
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 384 (2023)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/aa4e4ec8b1be476ba24f0f7a8a0e83ab
Autor:
Petr Šlechta, Adam Anthony Needle, Ondřej Jand’ourek, Pavla Paterová, Klára Konečná, Pavel Bárta, Jiří Kuneš, Vladimír Kubíček, Martin Doležal, Marta Kučerová-Chlupáčová
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2951 (2023)
Tuberculosis remains a serious killer among infectious diseases due to its incidence, mortality, and occurrence of resistant mycobacterial strains. The challenge to discover new antimycobacterial agents forced us to prepare a series of N-(1-hydroxy-1
Externí odkaz:
https://doaj.org/article/4fa4428dfe1442afbe0a7f273e8e7758
Autor:
Petr Šlechta, Ondřej Jand’ourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Vladimír Kubíček, Martin Doležal, Marta Kučerová-Chlupáčová
Publikováno v:
Medical Sciences Forum, Vol 14, Iss 1, p 133 (2022)
The current study is focused on the combination of pyrazinamide with 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol, which is a crucial pharmacophore of several antimicrobial agents. The use of benzoxaborole moiety could afford the formation of a spiro adduct
Externí odkaz:
https://doaj.org/article/e25ce61262bb44ff81190f948987b53c
Autor:
Vinod Sukanth Kumar Pallabothula, Marek Kerda, Martin Juhás, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Pavla Paterová, Jan Zitko
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1561 (2022)
Multidrug-resistant tuberculosis (MDR-TB) poses a significant threat to mankind and as such earned its place on the WHO list of priority pathogens. New antimycobacterials with a mechanism of action different to currently used agents are highly requir
Externí odkaz:
https://doaj.org/article/8407d76be4d84611821259c8a5fa6dd2
Autor:
Martin Juhás, Andrea Bachtíková, Daria Elżbieta Nawrot, Paulína Hatoková, Vinod Sukanth Kumar Pallabothula, Adéla Diepoltová, Ondřej Janďourek, Pavel Bárta, Klára Konečná, Pavla Paterová, Vít Šesták, Jan Zitko
Publikováno v:
Pharmaceuticals, Vol 15, Iss 5, p 580 (2022)
Antimicrobial drug resistance is currently one of the most critical health issues. Pathogens resistant to last-resort antibiotics are increasing, and very few effective antibacterial agents have been introduced in recent years. The promising drug can
Externí odkaz:
https://doaj.org/article/272fa446ccac49b29f63ff1088d904e1
Synthesis, Biological Evaluation, and In Silico Modeling of N-Substituted Quinoxaline-2-Carboxamides
Autor:
Ghada Bouz, Sarah Bouz, Ondřej Janďourek, Klára Konečná, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko
Publikováno v:
Pharmaceuticals, Vol 14, Iss 8, p 768 (2021)
Despite the established treatment regimens, tuberculosis remains an alarming threat to public health according to WHO. Novel agents are needed to overcome the increasing rate of resistance and perhaps achieve eradication. As part of our long-term res
Externí odkaz:
https://doaj.org/article/9837cdb516af40088446b84f4bb1efd2
Autor:
Ghada Bouz, Petr Šlechta, Ondřej Jand’ourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Martin Novák, Radim Kučera, Nils-Jørgen Knudsen Dal, Federico Fenaroli, Júlia Zemanová, Martin Forbak, Jana Korduláková, Oto Pavliš, Pavla Kubíčková, Martin Doležal, Jan Zitko
Publikováno v:
ACS infectious diseases.
Apart from the SARS-CoV-2 virus, tuberculosis remains the leading cause of death from a single infectious agent according to the World Health Organization. As part of our long-term research, we prepared a series of hybrid compounds combining pyrazina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f45d64c58a61c965726926767b4911
https://pubmed.ncbi.nlm.nih.gov/36577009
https://pubmed.ncbi.nlm.nih.gov/36577009
Autor:
Weronika Ambrożkiewicz, Marta Kučerová-Chlupáčová, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko
Publikováno v:
Molecules, Vol 25, Iss 7, p 1561 (2020)
According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year. The rising resistance developed by Mycobacterium tuberculosis a
Externí odkaz:
https://doaj.org/article/cbb2f0eea373485fbfbe31ebb479da48