Silencing Parkinson's risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability.

Autor: Kearney PJ; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA.; University of California, San Diego, CA, USA., Zhang Y; Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Liang M; Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Tan Y; Mass Spectrometry Facility, Department of Biochemistry and Molecular Biotechnology, UMASS Chan Medical School, Worcester, MA, USA.; DMPK Group, Merck, S. San Francisco, CA, USA., Kahuno E; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA., Conklin TL; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Regeneron, Albany, NY, USA., Fagan RR; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA.; University of California, San Francisco, CA, USA., Pavchinskiy RG; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA., Shaffer SA; Mass Spectrometry Facility, Department of Biochemistry and Molecular Biotechnology, UMASS Chan Medical School, Worcester, MA, USA., Yue Z; Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Melikian HE; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA, USA. haley.melikian@umassmed.edu.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA, USA. haley.melikian@umassmed.edu.

Publikováno v: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2024 Feb 23; Vol. 10 (1), pp. 41. Date of Electronic Publication: 2024 Feb 23.

Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype.

Autor: Kearney PJ; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA., Zhang Y; Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY., Tan Y; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA; Department of Biochemistry and Molecular Pharmacology, UMASS Chan Medical School, Worcester, MA., Kahuno E; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA., Conklin TL; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA., Fagan RR; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA., Pavchinskiy RG; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA., Shafer SA; Mass Spectrometry Facility, University of Massachusetts Medical School, Shrewsbury, MA; Department of Biochemistry and Molecular Pharmacology, UMASS Chan Medical School, Worcester, MA., Yue Z; Department of Neurology and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY., Melikian HE; Brudnick Neuropsychiatric Research Institute, Department of Neurobiology, UMASS Chan Medical School, Worcester, MA.; Graduate Program in Neuroscience, Morningside Graduate School of Biomedical Sciences, UMass Chan Medical School, Worcester, MA.

Publikováno v: Research square [Res Sq] 2023 May 25. Date of Electronic Publication: 2023 May 25.