Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Pavani Chalasani"'
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 4, Iss 4, Pp 616-629 (2023)
Epidermal growth factor receptor (EGFR) is one of the most well-studied oncogenes with roles in proliferation, growth, metastasis, and therapeutic resistance. This intense study has led to the development of a range of targeted therapeutics including
Externí odkaz:
https://doaj.org/article/b40b77a5b54346b8a5c7c6907f12d39f
Autor:
R. C. Coombes, Sacha Howell, Simon R. Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I. Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason Melear, Joyce O’Shaughnessy, Patrick Ward, Pavani Chalasani, Tobias Arkenau, Richard D. Baird, Rinath Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G. Krebs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Samuraciclib is a selective oral CDK7-inhibitor. A multi-modular, open-label Phase I study to evaluate safety and tolerability of samuraciclib in patients with advanced malignancies was designed (ClinicalTrials.gov: NCT03363893). Here we rep
Externí odkaz:
https://doaj.org/article/b14be29b81754bafad04d4aa37714251
Autor:
Phillip H. Kuo, Allison Yu-Chin Chen, Rudolph J. Rodriguez, Carol Stuehm, Pavani Chalasani, Nan-Kuei Chen, Ying-Hui Chou
Publikováno v:
Sensors, Vol 23, Iss 19, p 8017 (2023)
This pilot feasibility study aimed to evaluate the effects of transcranial magnetic stimulation (TMS) on chemotherapy-related cognitive impairment (CRCI), and we report here on the first patient. Background: Deleterious cognitive changes due to chemo
Externí odkaz:
https://doaj.org/article/a651913ffe0948ddb523749457859207
Autor:
R. C. Coombes, Sacha Howell, Simon R. Lord, Laura Kenny, Janine Mansi, Zahi Mitri, Carlo Palmieri, Linnea I. Chap, Paul Richards, William Gradishar, Sagar Sardesai, Jason Melear, Joyce O’Shaughnessy, Patrick Ward, Pavani Chalasani, Tobias Arkenau, Richard D. Baird, Rinath Jeselsohn, Simak Ali, Glen Clack, Ashwani Bahl, Stuart McIntosh, Matthew G. Krebs
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/4ff05e79a58f49b980db63215fe0a4b3
Autor:
Jessica A. Martinez, Betsy C. Wertheim, Denise J. Roe, Mihra S. Taljanovic, H-H. Sherry Chow, Wade Chew, Sima Ehsani, Sao Jiralerspong, Jennifer Segar, Pavani Chalasani
Publikováno v:
Metabolites, Vol 13, Iss 3, p 452 (2023)
Aromatase inhibitor-induced arthralgia (AIA) presents a major problem for patients with breast cancer but is poorly understood. This prospective study explored the inflammatory metabolomic changes in the development of AIA. This single-arm, prospecti
Externí odkaz:
https://doaj.org/article/5e6d69367c114bd8b2fdfb9833566b5e
Autor:
Jessica A. Martinez, Mihra S. Taljanovic, Andres A. Nuncio Zuniga, Betsy C. Wertheim, Denise J. Roe, Sima Ehsani, Sao Jiralerspong, Jennifer Segar, Pavani Chalasani
Publikováno v:
Journal of Clinical Medicine, Vol 11, Iss 4, p 1067 (2022)
Aromatase inhibitor-induced arthralgia (AIA) comprises significant, activity-limiting musculoskeletal symptoms, including joint pain, myalgia, and joint stiffness. We conducted a prospective feasibility study in postmenopausal women diagnosed with ea
Externí odkaz:
https://doaj.org/article/5698cf5a13814900a01567006f513f5b
Autor:
Jennifer M. Segar, Ritu Pandey, Kiah J. Farr, Raymond Nagle, Lauren LeBeau, Victor J. Gonzalez, Pavani Chalasani
Publikováno v:
International Journal of Breast Cancer, Vol 2020 (2020)
Pleomorphic invasive lobular carcinoma (PILC) is a distinct morphological and biologically aggressive variant of invasive lobular carcinoma (ILC). We hypothesized that was due to de novo activation of PI3K/Akt/mTOR pathway in PILC resulting in higher
Externí odkaz:
https://doaj.org/article/92af8d3a10944d48adb146d2316ce67a
Autor:
Ryan Sprissler, Bryce Perkins, Laurel Johnstone, Hani M. Babiker, Pavani Chalasani, Branden Lau, Michael Hammer, Daruka Mahadevan
Publikováno v:
Cancers, Vol 12, Iss 6, p 1618 (2020)
Whole exome sequencing (WES) of matched tumor-normal pairs in rare tumors has the potential to identify genome-wide mutations and copy number alterations (CNAs). We evaluated 27 rare cancer patients with tumor-normal matching by WES and tumor-only ne
Externí odkaz:
https://doaj.org/article/35dec476db914987a9cd21e99864f514
Autor:
Hsu-Chih Chien, Yea-Huei Kao Yang, C. Kent Kwoh, Pavani Chalasani, Debbie L. Wilson, Wei-Hsuan Lo-Ciganic
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 2, p 566 (2020)
Tamoxifen or aromatase inhibitor (AI) therapy may prevent breast cancer recurrence, however, adverse effects may lead to treatment discontinuation. Evidence regarding the occurrence of AI-associated musculoskeletal problems among Asians is scarce. We
Externí odkaz:
https://doaj.org/article/872ee6adbb7e4212bfcdad1681042411
Publikováno v:
Archives of Breast Cancer, Vol 5, Iss 3 (2018)
Background: Occult primary breast cancer is a presentation of breast cancer involving lymph nodes without an identified primary tumor within the breast. Mastectomy with axillary node dissection has been the traditional management. However, reported o
Externí odkaz:
https://doaj.org/article/0abd9cc2487244439d6e4ff5cbf1b26f