Výsledky vyhledávání - "Pavandeep Ghataorhe"

Immunoglobulin-driven Complement Activation Regulates Proinflammatory Remodeling in Pulmonary Hypertension

Publikováno v: American Journal of Respiratory and Critical Care Medicine

Rationale: Pulmonary hypertension (PH) is a life-threatening cardiopulmonary disorder in which inflammation and immunity have emerged as critical early pathogenic elements. Although proinflammatory processes in PH and pulmonary arterial hypertension

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae262e1e465000c232d4aacd14e460c6
http://europepmc.org/articles/PMC6961733

Zobrazit plný text záznamu

Exploring alternative dosing regimens of single-agent belantamab mafodotin on safety and efficacy in patients with relapsed or refractory multiple myeloma: DREAMM-14

Autor: Malin Hultcrantz, David Kleinman, Pavandeep Ghataorhe, Astrid McKeown, Wei He, Thomas Ling, Roxanne C. Jewell, Julie Byrne, Laurie Eliason, Emma Catherine Scott, Joanna Opalinska

Publikováno v: Journal of Clinical Oncology. 40:TPS8073-TPS8073

TPS8073 Background: Belantamab mafodotin (belamaf: BLENREP) is a first-in-class, monomethyl auristatin F (MMAF)-containing, B-cell maturation antigen (BCMA)-directed antibody–drug conjugate (ADC). In the DREAMM-2 study, belamaf showed deep response

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ae0998c5b42adf00d4ea126ca63fbfe
https://doi.org/10.1200/jco.2022.40.16_suppl.tps8073

Zobrazit plný text záznamu

Exploring Alternative Dosing Regimens of Single-Agent Belantamab Mafodotin on Safety and Efficacy in Patients with Relapsed or Refractory Multiple Myeloma: DREAMM-14

Autor: Malin Hultcrantz, Thomas Ling, Emma C. Scott, Laurie Eliason, Julie Byrne, Joanna Opalinska, Wei He, Pavandeep Ghataorhe, Joseph Brunner, Roxanne C. Jewell, David M. Kleinman, Astrid McKeown

Publikováno v: Blood. 138:1645-1645

Introduction: Belantamab mafodotin is a first-in-class, monomethyl auristatin F (MMAF)-containing, B-cell maturation antigen (BCMA)-directed antibody-drug conjugate (ADC) that is approved in the United States and European Union for adult patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3345a9cf83bdf4b4ac394c2b906fc9c4
https://doi.org/10.1182/blood-2021-152224

Zobrazit plný text záznamu

Pulmonary arterial hypertension - progress in understanding the disease and prioritizing strategies for drug development

Autor: John Wharton, Christopher J. Rhodes, Martin R. Wilkins, Lars Harbaum, Pavandeep Ghataorhe, Mark I Attard

Publikováno v: Journal of Internal Medicine. 282:129-141

Pulmonary arterial hypertension (PAH), at one time a largely overlooked disease, is now the subject of intense study in many academic and biotech groups. The availability of new treatments has increased awareness of the condition. This in turn has dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7998221c9e1faea54ced164565e941a
https://doi.org/10.1111/joim.12623

Zobrazit plný text záznamu

Plasma metabolomics exhibit response to therapy in chronic thromboembolic pulmonary hypertension

Autor: Martin R. Wilkins, Dolores Taboada, John Cannon, Christopher J. Rhodes, Pavandeep Ghataorhe, Kasia Zalewska, Mark Toshner, Emilia M. Swietlik, John Wharton, Nicholas W. Morrell, Joanna Pepke-Zaba, Luke Howard

Publikováno v: The European Respiratory Journal
article-version (VoR) Version of Record

Pulmonary hypertension is a condition with limited effective treatment options. Chronic thromboembolic pulmonary hypertension (CTEPH) is a notable exception, with pulmonary endarterectomy (PEA) often proving curative. This study investigated the plas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fbb5df7d9aa6066c63e881b46279f8
https://doi.org/10.1183/13993003.03201-2020

Zobrazit plný text záznamu

Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension

Autor: Lars, Harbaum, Pavandeep, Ghataorhe, John, Wharton, Beatriz, Jiménez, Luke S G, Howard, J Simon R, Gibbs, Jeremy K, Nicholson, Christopher J, Rhodes, Martin R, Wilkins

Publikováno v: Thorax. 74(4)

Aberrant lipoprotein metabolism has been implicated in experimental pulmonary hypertension, but the relevance to patients with pulmonary arterial hypertension (PAH) is inconclusive.To investigate the relationship between circulating lipoprotein subcl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::569e1253d92b048c6b4d383f99c0dfee
https://pubmed.ncbi.nlm.nih.gov/30679265

Zobrazit plný text záznamu

Why drugs fail in clinical trials in pulmonary arterial hypertension, and strategies to succeed in the future

Autor: Pavandeep Ghataorhe, Martin R. Wilkins, Christopher J. Rhodes, John Wharton, Mark P. Lythgoe, Mark I Attard

The past three decades have witnessed a welcome expansion of the therapeutic armamentarium for the management of pulmonary arterial hypertension (PAH). However, against this backdrop, there have been some notable disappointments in drug development.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dffae7ec9e35a162b8edce055849100
http://hdl.handle.net/10044/1/32478

Zobrazit plný text záznamu

A carrier of both MEN1 and BRCA2 mutations: case report and review of the literature

Autor: Jeffrey A. Norton, Pamela Trapane, Angela Pickart, James M. Ford, Pavandeep Ghataorhe, Kerry Kingham, Allison W. Kurian

Publikováno v: Cancer Genetics and Cytogenetics. 179:89-92

High-penetrance autosomal dominant cancer susceptibility genes such as BRCA2 and MEN1 result in specific patterns of cancers in individuals who inherit germline mutations. Their incidence in the population is relatively low, however, and it is highly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ce2c2c6927723f7afa88a2f8d6a4de
https://doi.org/10.1016/j.cancergencyto.2007.08.009

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání