Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Pavana M. Hegde"'
Autor:
Manohar Kodavati, Haibo Wang, Wenting Guo, Joy Mitra, Pavana M. Hegde, Vincent Provasek, Vikas H. Maloji Rao, Indira Vedula, Aijun Zhang, Sankar Mitra, Alan E. Tomkinson, Dale J. Hamilton, Ludo Van Den Bosch, Muralidhar L. Hegde
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract This study establishes the physiological role of Fused in Sarcoma (FUS) in mitochondrial DNA (mtDNA) repair and highlights its implications to the pathogenesis of FUS-associated neurodegenerative diseases such as amyotrophic lateral sclerosi
Externí odkaz:
https://doaj.org/article/84695b5aec76489b85b86bbc091bf336
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-4 (2019)
Abstract Synaptic abnormalities, perturbed endosomal recycling mediated by loss of the small GTPase RAB11, and neuroinflammatory signaling have been associated with multiple neurodegenerative diseases including the motor neuron disease, amyotrophic l
Externí odkaz:
https://doaj.org/article/7dd2ab58ae464f2dabf558549f01a638
Autor:
Haibo Wang, Wenting Guo, Joy Mitra, Pavana M. Hegde, Tijs Vandoorne, Bradley J. Eckelmann, Sankar Mitra, Alan E. Tomkinson, Ludo Van Den Bosch, Muralidhar L. Hegde
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Impairment of DNA repair has been associated with neurodegeneration. Here the authors investigate the mechanisms of defects in repair caused by mutations in the RNA/DNA binding protein FUS in amyotrophic lateral sclerosis and elucidate its role in th
Externí odkaz:
https://doaj.org/article/6f901ba774c14e7094bb810d29ed252a
Autor:
Joy Mitra, Erika N. Guerrero, Pavana M. Hegde, Haibo Wang, Istvan Boldogh, Kosagi Sharaf Rao, Sankar Mitra, Muralidhar L. Hegde
Publikováno v:
Biomolecules, Vol 4, Iss 3, Pp 678-703 (2014)
The primary cause(s) of neuronal death in most cases of neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are still unknown. However, the association of certain etiological factors, e.g., oxidative stress, protein misfold
Externí odkaz:
https://doaj.org/article/d51bec5ee749455a80186eac29894330
Publikováno v:
Biomolecules, Vol 2, Iss 4, Pp 564-578 (2012)
NEIL1 is unique among the oxidatively damaged base repair-initiating DNA glycosylases in the human genome due to its S phase-specific activation and ability to excise substrate base lesions from single-stranded DNA. We recently characterized NEIL1’
Externí odkaz:
https://doaj.org/article/875e831382f24b0195686d5a67c72a36
Autor:
Muralidhar L. Hegde, Velmarini Vasquez, Trenton Roy, Thomas A. Kent, Istvan Boldogh, Prakash Dharmalingam, Emily A. McHugh, Kimberly Mendoza, Joy Mitra, James M. Tour, Roderic H. Fabian, Girish Talakatta, Lizanne G. Nilewski, Haibo Wang, Sankar Mitra, Venkatesh L. Hegde, Paul J. Derry, Pavana M. Hegde, Eugenia Kakadiaris
Publikováno v:
ACS Nano
Therapy for intracerebral hemorrhage (ICH) remains elusive, in part dependent on the severity of the hemorrhage itself as well as multiple deleterious effects of blood and its breakdown products such as hemin and free iron. While oxidative injury and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7469562987d76f3e88731b9a0bf7d137
https://doi.org/10.1021/acsnano.9b05821
https://doi.org/10.1021/acsnano.9b05821
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-4 (2019)
Molecular Brain
Molecular Brain
Synaptic abnormalities, perturbed endosomal recycling mediated by loss of the small GTPase RAB11, and neuroinflammatory signaling have been associated with multiple neurodegenerative diseases including the motor neuron disease, amyotrophic lateral sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c744009f44c24f733e58c77aa48730fa
http://link.springer.com/article/10.1186/s13041-019-0475-y
http://link.springer.com/article/10.1186/s13041-019-0475-y
Autor:
J. Paul Taylor, Muralidhar L. Hegde, Ping Wu, Velmarini Vasquez, Erika N. Guerrero, Brian C. Kraemer, Nicole F. Liachko, Pavana M. Hegde, Sankar Mitra, Junling Gao, Haibo Wang, Ralph M. Garruto, Arvind Pandey, Joy Mitra, Istvan Boldogh, K.S.J. Rao
Publikováno v:
Proceedings of the National Academy of Sciences. 116:4696-4705
Genome damage and their defective repair have been etiologically linked to degenerating neurons in many subtypes of amyotrophic lateral sclerosis (ALS) patients; however, the specific mechanisms remain enigmatic. The majority of sporadic ALS patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::beb289e934ecdedfeaa358ff3601a158
https://doi.org/10.1073/pnas.1818415116
https://doi.org/10.1073/pnas.1818415116
Publikováno v:
Prog Neurobiol
α-Synuclein is a hallmark amyloidogenic protein component of the Lewy bodies (LBs) that are found in dopaminergic neurons affected by Parkinson’s disease (PD). Despite an enormous increase in emerging knowledge, the mechanism(s) of α-synuclein ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c7b5ffaee1ea9549ad9745c5dd2a4a
https://europepmc.org/articles/PMC7098698/
https://europepmc.org/articles/PMC7098698/
Autor:
Shiladitya Sengupta, Arvind Pandey, Abdul Tayyeb Datarwala, Arijit Dutta, Sankar Mitra, Chunying Yang, Pavana M. Hegde, Joy Mitra, Kishor K. Bhakat, Muralidhar L. Hegde
Publikováno v:
DNA Repair. :1-10
Posttranslational modifications of DNA repair proteins have been linked to their function. However, it is not clear if posttranslational acetylation affects subcellular localization of these enzymes. Here, we show that the human DNA glycosylase NEIL1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc7a5b78d02e20489f03aaf4602a788
https://doi.org/10.1016/j.dnarep.2018.04.001
https://doi.org/10.1016/j.dnarep.2018.04.001