Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Pavan S. Upadhyayula"'
Autor:
Pavan S. Upadhyayula, Dominique M. Higgins, Angeliki Mela, Matei Banu, Athanassios Dovas, Fereshteh Zandkarimi, Purvi Patel, Aayushi Mahajan, Nelson Humala, Trang T. T. Nguyen, Kunal R. Chaudhary, Lillian Liao, Michael Argenziano, Tejaswi Sudhakar, Colin P. Sperring, Benjamin L. Shapiro, Eman R. Ahmed, Connor Kinslow, Ling F. Ye, Markus D. Siegelin, Simon Cheng, Rajesh Soni, Jeffrey N. Bruce, Brent R. Stockwell, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Diet intervention is emerging as an option to improve cancer therapy. Here, the authors show that a diet with restrictive cysteine and methionine synergizes with a ferroptosis inducer to increase cell death and survival in glioma preclinical models.
Externí odkaz:
https://doaj.org/article/d887ba793f1142b985b1d97d66d45514
Autor:
Andrew X. Chen, Robyn D. Gartrell, Junfei Zhao, Pavan S. Upadhyayula, Wenting Zhao, Jinzhou Yuan, Hanna E. Minns, Athanassios Dovas, Jeffrey N. Bruce, Anna Lasorella, Antonio Iavarone, Peter Canoll, Peter A. Sims, Raul Rabadan
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background Macrophages are the most common infiltrating immune cells in gliomas and play a wide variety of pro-tumor and anti-tumor roles. However, the different subpopulations of macrophages and their effects on the tumor microenvironment r
Externí odkaz:
https://doaj.org/article/d861900a897a459a945d33e79ba44a01
Autor:
Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer, John R. Henley
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic properties, has been implica
Externí odkaz:
https://doaj.org/article/1d0c9d1a12074eb5801bde5c8e5fa9b3
Autor:
Huizhong Feng, Kenji Schorpp, Jenny Jin, Carrie E. Yozwiak, Benjamin G. Hoffstrom, Aubrianna M. Decker, Presha Rajbhandari, Michael E. Stokes, Hannah G. Bender, Joleen M. Csuka, Pavan S. Upadhyayula, Peter Canoll, Koji Uchida, Rajesh K. Soni, Kamyar Hadian, Brent R. Stockwell
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3411-3423.e7 (2020)
Summary: Ferroptosis is a type of regulated cell death driven by the iron-dependent accumulation of oxidized polyunsaturated fatty acid-containing phospholipids. There is no reliable way to selectively stain ferroptotic cells in tissue sections to ch
Externí odkaz:
https://doaj.org/article/c63fa17fdc6c49d3bd4dbc9c3951b70a
Autor:
John K. Yue, Caitlin K. Robinson, Ethan A. Winkler, Pavan S. Upadhyayula, John F. Burke, Romain Pirracchio, Catherine G. Suen, Hansen Deng, Laura B. Ngwenya, Sanjay S. Dhall, Geoffrey T. Manley, Phiroz E. Tarapore
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 2, Iss , Pp 85-93 (2017)
Introduction: The Glasgow Coma Scale (GCS) score is the primary method of assessing consciousness after traumatic brain injury (TBI), and the clinical standard for classifying TBI severity. There is scant literature discerning the influence of circad
Externí odkaz:
https://doaj.org/article/e5df9f369f144468bb5bee2ac1bb867f
Autor:
Pavan S. Upadhyayula, Eleonora F. Spinazzi, Michael G. Argenziano, Peter Canoll, Jeffrey N. Bruce
Publikováno v:
Pharmaceutics, Vol 13, Iss 1, p 39 (2020)
A key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manu
Externí odkaz:
https://doaj.org/article/3933523317a84f3895b8b0bf7135cff9
Autor:
Hansen Deng, John K. Yue, Benjamin E. Zusman, Enyinna L. Nwachuku, Hussam Abou-Al-Shaar, Pavan S. Upadhyayula, David O. Okonkwo, Ava M. Puccio
Publikováno v:
Medicina, Vol 56, Iss 6, p 300 (2020)
Background and Objectives: The injury burden after head trauma is exacerbated by secondary sequelae, which leads to further neuronal loss. B-cell lymphoma 2 (Bcl-2) is an anti-apoptotic protein and a key modulator of the programmed cell death (PCD) p
Externí odkaz:
https://doaj.org/article/a755fe3227154b04a0bdd7bb233d70ec
Publikováno v:
Medicina, Vol 56, Iss 2, p 87 (2020)
Background and Objectives: The annual global incidence of traumatic brain injury (TBI) is over 10 million. An estimated 29% of TBI patients with negative computed tomography (CT−) have positive magnetic resonance imaging (MRI+) findings. Judicious
Externí odkaz:
https://doaj.org/article/9d7ee21487c44ffb9929517e980f6b07
Publikováno v:
Brain Sciences, Vol 10, Iss 3, p 135 (2020)
Introduction: Traumatic brain injury (TBI) remains a primary cause of pediatric morbidity. The improved characterization of healthcare disparities for pediatric TBI in United States (U.S.) rural communities is needed to advance care. Methods: The Pub
Externí odkaz:
https://doaj.org/article/9e370a0b9ed04c668589e9745ba69711
Autor:
Hansen Deng, Angel Ordaz, Pavan S. Upadhyayula, Eva M. Gillis-Buck, Catherine G. Suen, Caroline G. Melhado, Nebil Mohammed, Troy Lam, John K. Yue
Publikováno v:
Medical Sciences, Vol 6, Iss 3, p 78 (2018)
The annual incidence of mild traumatic brain injury (MTBI) is 3.8 million in the USA with 10–15% experiencing persistent morbidity beyond one year. Chronic traumatic encephalopathy (CTE), a neurodegenerative disease characterized by accumulation of
Externí odkaz:
https://doaj.org/article/793313b9ce714f1abdf133c313c7c8a1