Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Pavan S, Upadhyayula"'
Autor:
Pavan S. Upadhyayula, Dominique M. Higgins, Angeliki Mela, Matei Banu, Athanassios Dovas, Fereshteh Zandkarimi, Purvi Patel, Aayushi Mahajan, Nelson Humala, Trang T. T. Nguyen, Kunal R. Chaudhary, Lillian Liao, Michael Argenziano, Tejaswi Sudhakar, Colin P. Sperring, Benjamin L. Shapiro, Eman R. Ahmed, Connor Kinslow, Ling F. Ye, Markus D. Siegelin, Simon Cheng, Rajesh Soni, Jeffrey N. Bruce, Brent R. Stockwell, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Diet intervention is emerging as an option to improve cancer therapy. Here, the authors show that a diet with restrictive cysteine and methionine synergizes with a ferroptosis inducer to increase cell death and survival in glioma preclinical models.
Externí odkaz:
https://doaj.org/article/d887ba793f1142b985b1d97d66d45514
Autor:
Andrew X. Chen, Robyn D. Gartrell, Junfei Zhao, Pavan S. Upadhyayula, Wenting Zhao, Jinzhou Yuan, Hanna E. Minns, Athanassios Dovas, Jeffrey N. Bruce, Anna Lasorella, Antonio Iavarone, Peter Canoll, Peter A. Sims, Raul Rabadan
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background Macrophages are the most common infiltrating immune cells in gliomas and play a wide variety of pro-tumor and anti-tumor roles. However, the different subpopulations of macrophages and their effects on the tumor microenvironment r
Externí odkaz:
https://doaj.org/article/d861900a897a459a945d33e79ba44a01
Autor:
Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer, John R. Henley
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-13 (2020)
Abstract Background Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic properties, has been implica
Externí odkaz:
https://doaj.org/article/1d0c9d1a12074eb5801bde5c8e5fa9b3
Reproducible analysis of disease space via principal components using the novel R package syndRomics
Autor:
Abel Torres-Espín, Austin Chou, J Russell Huie, Nikos Kyritsis, Pavan S Upadhyayula, Adam R Ferguson
Publikováno v:
eLife, Vol 10 (2021)
Biomedical data are usually analyzed at the univariate level, focused on a single primary outcome measure to provide insight into systems biology, complex disease states, and precision medicine opportunities. More broadly, these complex biological an
Externí odkaz:
https://doaj.org/article/5a86b87ab3604f2194bf6810870d7f23
Autor:
Huizhong Feng, Kenji Schorpp, Jenny Jin, Carrie E. Yozwiak, Benjamin G. Hoffstrom, Aubrianna M. Decker, Presha Rajbhandari, Michael E. Stokes, Hannah G. Bender, Joleen M. Csuka, Pavan S. Upadhyayula, Peter Canoll, Koji Uchida, Rajesh K. Soni, Kamyar Hadian, Brent R. Stockwell
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3411-3423.e7 (2020)
Summary: Ferroptosis is a type of regulated cell death driven by the iron-dependent accumulation of oxidized polyunsaturated fatty acid-containing phospholipids. There is no reliable way to selectively stain ferroptotic cells in tissue sections to ch
Externí odkaz:
https://doaj.org/article/c63fa17fdc6c49d3bd4dbc9c3951b70a
Autor:
John K. Yue, Caitlin K. Robinson, Ethan A. Winkler, Pavan S. Upadhyayula, John F. Burke, Romain Pirracchio, Catherine G. Suen, Hansen Deng, Laura B. Ngwenya, Sanjay S. Dhall, Geoffrey T. Manley, Phiroz E. Tarapore
Publikováno v:
Neurobiology of Sleep and Circadian Rhythms, Vol 2, Iss , Pp 85-93 (2017)
Introduction: The Glasgow Coma Scale (GCS) score is the primary method of assessing consciousness after traumatic brain injury (TBI), and the clinical standard for classifying TBI severity. There is scant literature discerning the influence of circad
Externí odkaz:
https://doaj.org/article/e5df9f369f144468bb5bee2ac1bb867f
Publikováno v:
Journal of Craniovertebral Junction and Spine, Vol 8, Iss 3, Pp 222-230 (2017)
Objective: Cervical spine fusion is the preferred treatment modality for a variety of degenerative and/or myelopathic disorders. Surgeons select between two approaches (anterior or posterior cervical fusion [ACF; PCF]) based on pathoanatomical featur
Externí odkaz:
https://doaj.org/article/7bb9fb6d7ac84b468f2ef6ac78778d2e
Autor:
Connor J. Kinslow, Ann Mercurio, Prashanth Kumar, Ali I. Rae, Markus D. Siegelin, Jack Grinband, Kekoa Taparra, Pavan S. Upadhyayula, Guy M. McKhann, Michael B. Sisti, Jeffrey N. Bruce, Peter D. Canoll, Fabio M. Iwamoto, Lisa A. Kachnic, James B. Yu, Simon K. Cheng, Tony J. C. Wang
Publikováno v:
JAMA Oncology.
ImportanceO6-methylguanine-DNA methyltransferase (MGMT [OMIM 156569]) promoter methylation (mMGMT) is predictive of response to alkylating chemotherapy for glioblastomas and is routinely used to guide treatment decisions. However, the utility of MGMT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0637ca45c116166945b6d7735a266fc1
https://doi.org/10.1001/jamaoncol.2023.0990
https://doi.org/10.1001/jamaoncol.2023.0990
Autor:
Matei A. Banu, Athanassios Dovas, Michael G. Argenziano, Wenting Zhao, Henar Cuervo Grajal, Dominique M.O. Higgins, Colin P. Sperring, Brianna Pereira, Ling F. Ye, Aayushi Mahajan, Nelson Humala, Julia L. Furnari, Pavan S. Upadhyayula, Fereshteh Zandkarimi, Trang T. T. Nguyen, Peter B. Wu, Li Hai, Charles Karan, Aida Razavilar, Markus D. Siegelin, Jan Kitajewski, Jeffrey N. Bruce, Brent R. Stockwell, Peter A. Sims, Peter D. Canoll
Publikováno v:
bioRxiv
SUMMARYGlioma cells hijack developmental transcriptional programs to control cell state. During neural development, lineage trajectories rely on specialized metabolic pathways. However, the link between tumor cell state and metabolic programs is poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d307a66d6e7e7bb3360567afe6f972d
https://doi.org/10.1101/2023.02.22.529581
https://doi.org/10.1101/2023.02.22.529581
Autor:
Colin P Sperring, Michael G Argenziano, William M Savage, Damian E Teasley, Pavan S Upadhyayula, Nathan J Winans, Peter Canoll, Jeffrey N Bruce
Publikováno v:
Neuro-Oncology Advances. 5
The prognosis for glioblastoma has remained poor despite multimodal standard of care treatment, including temozolomide, radiation, and surgical resection. Further, the addition of immunotherapies, while promising in a number of other solid tumors, ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb14ffea8c9f8d160f44efc8466b1a63
https://doi.org/10.1093/noajnl/vdad044
https://doi.org/10.1093/noajnl/vdad044