Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Pavan Puligujja"'
Autor:
Andrea L Martinez-Skinner, Mariluz A Araínga, Pavan Puligujja, Diana L Palandri, Hannah M Baldridge, Benson J Edagwa, JoEllyn M McMillan, R Lee Mosley, Howard E Gendelman
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145966 (2015)
Long-acting nanoformulated antiretroviral therapy (nanoART) induces a range of innate immune migratory, phagocytic and secretory cell functions that perpetuate drug depots. While recycling endosomes serve as the macrophage subcellular depots, little
Externí odkaz:
https://doaj.org/article/4edb165520984c83af62b4a2df1b1354
Autor:
Yazen Alnouti, Howard E. Gendelman, Tian Zhou, James R. Hilaire, Zhiyi Lin, JoEllyn M McMillan, Diana L. Palandri, Nathan Smith, Xin Ming Liu, Pavan Puligujja, Benson J Edagwa, Mariluz Araínga, Nagsen Gautam
Publikováno v:
Nanomedicine
Aim: While the therapeutic potential for current long-acting (LA) antiretroviral therapy (ART) is undeniable, ligand-decorated nanoformulated LA-ART could optimize drug delivery to viral reservoirs. The development of decorated ART hinges, however, o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::305f1f69e0bb77f3896b968b09e5b122
https://doi.org/10.2217/nnm-2017-0381
https://doi.org/10.2217/nnm-2017-0381
Autor:
Balasrinivasa R. Sajja, Howard E. Gendelman, Dongwei Guo, Xin Ming Liu, Tianyuzi Li, Pavan Puligujja, JoEllyn M McMillan, Michael D. Boska
Publikováno v:
Nanomedicine. 9:1341-1352
Aim: Drug toxicities, compliance and penetrance into viral reservoirs have diminished the efficacy of long-term antiretroviral therapy (ART) for treatment of HIV infection. Cell-targeted nanoformulated ART was developed to improve disease outcomes. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a946e6bb30a922a7d1c77f22c53c2b5e
https://doi.org/10.2217/nnm.13.92
https://doi.org/10.2217/nnm.13.92
Autor:
Howard E. Gendelman, Xin Ming Liu, Han Chen, Prabagaran Narayanasamy, Benson J Edagwa, Pavan Puligujja, Dongwei Guo, JoEllyn M McMillan
Publikováno v:
The FASEB Journal
Eradication of Mycobacterium tuberculosis (MTB) infection requires daily administration of combinations of rifampin (RIF), isoniazid [isonicotinylhydrazine (INH)], pyrazinamide, and ethambutol, among other drug therapies. To facilitate and optimize M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4307dc6b9a5043b2a22f15570ae7ce36
http://europepmc.org/articles/PMC4232285
http://europepmc.org/articles/PMC4232285
Autor:
Ram S. Veerubhotla, Alexander V. Kabanov, Shantanu Balkundi, Xin Ming Liu, Howard E. Gendelman, Lindsey M. Kendrick, JoEllyn M McMillan, Tatiana K. Bronich, Pavan Puligujja, Nathan Smith, Benson J Edagwa, Tianyuzi Li
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 9:1263-1273
Macrophages serve as vehicles for the carriage and delivery of polymer-coated nanoformulated antiretroviral therapy (nanoART). Although superior to native drug, high drug concentrations are required for viral inhibition. Herein, folate-modified riton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52748a3376bd1fbe71b4c61fadc34af6
https://doi.org/10.1016/j.nano.2013.05.003
https://doi.org/10.1016/j.nano.2013.05.003
Autor:
Howard S. Fox, Howard E. Gendelman, Shantanu Balkundi, Benjamin G. Lamberty, JoEllyn M McMillan, Xin Ming Liu, Nathan Smith, Brenda Morsey, Dongwei Guo, Pavan Puligujja, Nagsen Gautam, Upal Roy, Yazen Alnouti
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:3110-3120
Long-acting injectable nanoformulated antiretroviral therapy (nanoART) was developed with the explicit goal of improving medicine compliance and for drug targeting of viral tissue reservoirs. Prior nanoART studies completed in humanized virus-infecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cad57ed8848515a9c8ffda10264f689
https://doi.org/10.1128/aac.00267-13
https://doi.org/10.1128/aac.00267-13
Autor:
Mariluz Araínga, Santhi Gorantla, Diana L. Palandri, Larisa Y. Poluektova, JoEllyn M McMillan, Howard E. Gendelman, R. Lee Mosley, Pavan Puligujja, Prasanta K. Dash
Publikováno v:
Antiviral research. 120
Long acting nanoformulated antiretroviral therapy (nanoART) can sustain plasma drug levels and improve its biodistribution. Cell targeted-nanoART can achieve this and bring drug efficiently to viral reservoirs. However, if such improvements affect an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c58fd81a0396067505413650c7231d
https://pubmed.ncbi.nlm.nih.gov/26026666
https://pubmed.ncbi.nlm.nih.gov/26026666
Pharmacokinetics, biodistribution, and toxicity of folic acid-coated antiretroviral nanoformulations
Autor:
Howard E. Gendelman, Howard S. Fox, Pavan Puligujja, Yazen Alnouti, Shantanu Balkundi, Xin Ming Liu, JoEllyn M McMillan, Nagsen Gautam, Rhishikesh Thakare
Publikováno v:
Antimicrobial agents and chemotherapy. 58(12)
The drug delivery platform for folic acid (FA)-coated nanoformulated ritonavir (RTV)-boosted atazanavir (FA-nanoATV/r) using poloxamer 407 was developed to enhance cell and tissue targeting for a range of antiretroviral drugs. Such formulations would
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8694a6ffa7ccc2d8536085147855cc8c
https://pubmed.ncbi.nlm.nih.gov/25288084
https://pubmed.ncbi.nlm.nih.gov/25288084
Autor:
Tianlei Ying, Larisa Y. Poluektova, Xin Ming Liu, Aditya N. Bade, Santhi Gorantla, Prasanta K. Dash, Hannah M. Baldridge, Gang Zhang, Howard E. Gendelman, JoEllyn M McMillan, Lindsey M. Kendrick, Yang Feng, Pavan Puligujja, Dimiter S. Dimitrov, Yanping Wang, James R. Hilaire, Shantanu Balkundi
Publikováno v:
Biomaterials. 41
Long-acting nanoformulated antiretroviral therapy (nanoART) that target monocyte-macrophage could improve the drug’s half-life and protein binding capacities while facilitating cell and tissue depots. To this end, ART nanoparticles that target the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0a0bf95a80a4528d5989307ec47306
https://pubmed.ncbi.nlm.nih.gov/25522973
https://pubmed.ncbi.nlm.nih.gov/25522973
Autor:
Hannah M. Baldridge, Andrea Martinez-Skinner, Howard E. Gendelman, JoEllyn M McMillan, Mariluz Araínga, Benson J Edagwa, Diana L. Palandri, Pavan Puligujja, R. Lee Mosley
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 12, p e0145966 (2015)
PLoS ONE, Vol 10, Iss 12, p e0145966 (2015)
Long-acting nanoformulated antiretroviral therapy (nanoART) induces a range of innate immune migratory, phagocytic and secretory cell functions that perpetuate drug depots. While recycling endosomes serve as the macrophage subcellular depots, little
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8c76c4fcb14af631560dbd9359ab2a
https://doi.org/10.1371/journal.pone.0145966
https://doi.org/10.1371/journal.pone.0145966