Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Pavan Krishnamurthy"'
Autor:
Li Liu, Ian J. Orozco, Emmanuel Planel, Yi Wen, Alexis Bretteville, Pavan Krishnamurthy, Lili Wang, Mathieu Herman, Helen Figueroa, W. Haung Yu, Ottavio Arancio, Karen Duff
Publikováno v:
Neurobiology of Disease, Vol 31, Iss 1, Pp 46-57 (2008)
In the last decade, multiple lines of transgenic APP overexpressing mice have been created that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the previously reported transgenic APP overexpressing rat models developed AD-l
Externí odkaz:
https://doaj.org/article/176eaee9e6aa4b5a841142b79871d76d
Autor:
Eliot J. Davidowitz, Pavan Krishnamurthy, James G. Moe, Peter Davies, Patricia Lopez, Heidy Jimenez, Leslie Adrien
Publikováno v:
Journal of Alzheimer's disease : JAD. 73(1)
Tau oligomers have been shown to transmit tau pathology from diseased neurons to healthy neurons through seeding, tau misfolding, and aggregation that is thought to play an influential role in the progression of Alzheimer’s disease (AD) and related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e21498ab8efcbc00d7c7f0a3ef74b1
https://pubmed.ncbi.nlm.nih.gov/31771053
https://pubmed.ncbi.nlm.nih.gov/31771053
Autor:
Senthilkumar Krishnaswamy, Einar M. Sigurdsson, Wajitha J. Rajamohamedsait, Pavan Krishnamurthy, Yan Lin, Hameetha B. Rajamohamedsait
Publikováno v:
The Journal of Neuroscience. 34:16835-16850
Antibodies or their derivatives as imaging probes for pathological tau protein have great potential, but have not been well studied. In particular, smaller, single-chain-variable antibody fragments (scFv's) are attractive for detecting tau lesions in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5009153744320709bf23eb9f1c1b452e
https://doi.org/10.1523/jneurosci.2755-14.2014
https://doi.org/10.1523/jneurosci.2755-14.2014
Publikováno v:
Alzheimer's & Dementia. 13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::223073e1afd30f94e23eacee984c8bd5
https://doi.org/10.1016/j.jalz.2017.07.752
https://doi.org/10.1016/j.jalz.2017.07.752
Autor:
Senthilkumar Krishnaswamy, Einar M. Sigurdsson, Veronica Gonzalez, Wajitha J. Rajamohamedsait, Pavan Krishnamurthy, Hameetha B. Rajamohamedsait, Nawal Ahmed
Publikováno v:
Frontiers in Endocrinology
Type 2 diabetes mellitus is characterized by the deposition of islet amyloid polypeptide (IAPP) as amyloid in islets, a process thought to be toxic to β-cells. To determine the feasibility of targeting these aggregates therapeutically, we vaccinated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ede43f2b7cd6e6b11093c68b566926
https://doi.org/10.3389/fendo.2016.00062
https://doi.org/10.3389/fendo.2016.00062
Publikováno v:
Current Alzheimer Research. 8:666-677
Neurofibrillary tangles (NFTs) are one of the pathological hallmarks of Alzheimer's disease (AD) and are primarily composed of aggregates of hyperphosphorylated forms of the microtubule associated protein tau. It is likely that an imbalance of kinase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8410ecc9f26afb98b4276565cb82fcff
https://doi.org/10.2174/156720511796717195
https://doi.org/10.2174/156720511796717195
Autor:
Isabelle Marie, Li Liu, Pavan Krishnamurthy, Lit Fui Lau, Debomoy K. Lahiri, Emmanuel Planel, Yi Wen, Helen Y. Figueroa, Mathieu Herman, W. Haung Yu, Thomas Maurin, Junrong Ma, Jason A. Bailey, Bryan Maloney, Karen Duff, Lili Wang
Publikováno v:
Neuron. 57:680-690
SummaryCyclin-dependent kinase 5 (cdk5) has been implicated in Alzheimer's disease (AD) pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa3561192f09de6a0ad7ac318c97bae
https://doi.org/10.1016/j.neuron.2008.02.024
https://doi.org/10.1016/j.neuron.2008.02.024
Autor:
James G. Moe, Daisy Romero, Eliot J. Davidowitz, Patricia Lopez, Giulia Papiani, Pavan Krishnamurthy
Publikováno v:
Alzheimer's & Dementia. 11
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eafd9a14b93c422c3f708cefdb1267d4
https://doi.org/10.1016/j.jalz.2015.08.149
https://doi.org/10.1016/j.jalz.2015.08.149
Autor:
Eliot J. Davidowitz, Patricia Lopez, James Hendrix, Pavan Krishnamurthy, James G. Moe, Giulia Papiani
Publikováno v:
Alzheimer's & Dementia. 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30a51bdf90bfbdffc8a8006b62be909b
https://doi.org/10.1016/j.jalz.2014.05.1730
https://doi.org/10.1016/j.jalz.2014.05.1730
Autor:
Ashley M. Whelan, Helen Wong, Charles A. Hoeffer, Hameetha B. Rajamohamedsait, Einar M. Sigurdsson, Pavan Krishnamurthy, Josien Levenga
Publikováno v:
Alzheimer's & Dementia. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::260bfabbf9e9bb8b4d63054f702d8efa
https://doi.org/10.1016/j.jalz.2012.05.212
https://doi.org/10.1016/j.jalz.2012.05.212