Výsledky vyhledávání - "Pavan K. Kommareddi"

Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells

Autor: Lillian Lu, Thankam S. Nair, Pavan K. Kommareddi, Ariane Kanicki, Trey B. Thomas, Bala Naveen Kakaraparthi, Thomas E. Carey, Anna C. Morris, Lucy Yang

Publikováno v: Tissuecell. 73

Slc44a2 is reported to interact with tetraspanins CD9 and CD81. To investigate how Slc44a2 affects adhesion protein expression, cells from wild-type (WT) Slc44a2+/+, heterozygous (HET) Slc44a2+/-, and knockout (KO) Slc44a2-/- mice were cultured from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4480f9bfc0282ccea8b8e2050e12514
https://pubmed.ncbi.nlm.nih.gov/34371293

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Hair Cell Loss, Spiral Ganglion Degeneration, and Progressive Sensorineural Hearing Loss in Mice with Targeted Deletion of Slc44a2/Ctl2

Publikováno v: JARO: Journal of the Association for Research in Otolaryngology

SLC44A2 (solute carrier 44a2), also known as CTL2 (choline transporter-like protein 2), is expressed in many supporting cell types in the cochlea and is implicated in hair cell survival and antibody-induced hearing loss. In mice with the mixed C57BL/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92fc7acde5eca4bb1d0b6f0da6bec03c
https://doi.org/10.1007/s10162-015-0547-3

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Isoforms, Expression, Glycosylation, and Tissue Distribution of CTL2/SLC44A2

Autor: Pavan K. Kommareddi, Takeharu Kanazawa, Thomas E. Carey, Jonathan B. McHugh, Thankam S. Nair, Ellappan Babu, Vadivel Ganapathy, L. V. Thang, Maria M. Galano

Publikováno v: The Protein Journal. 29:417-426

Antibodies to the solute carrier protein, CTL2/SLC44A2, cause hearing loss in animals, are frequently found in autoimmune hearing loss patients, and are implicated in transfusion-related acute lung injury. We cloned a novel CTL2/SLC44A2 isoform (CTL2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09aa397d9e42eb6dbbc94afceb24622e
https://doi.org/10.1007/s10930-010-9268-y

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Autoantibodies to recombinant human CTL2 in autoimmune hearing loss

Autor: Robert T. Sataloff, Pavan K. Kommareddi, Steven A. Telian, Thomas E. Carey, Hussam K. El-Kashlan, Mounica Vallurupalli, Thankam S. Nair, H. Alexander Arts

Publikováno v: The Laryngoscope. 119:924-932

Objectives/Hypothesis: Choline transporter-like protein 2 (CTL2), a 68–72 kDa inner-ear membrane glycoprotein, is a candidate target antigen in autoimmune hearing loss (AIHL). The objective of this study was to test recombinant human CTL2 as a pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1185027a54a3902834185a7c4c4fa1
https://doi.org/10.1002/lary.20136

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Galanin Receptor Subtype 2 Suppresses Cell Proliferation and Induces Apoptosis in p53 Mutant Head and Neck Cancer Cells

Autor: Takeharu Kanazawa, Yuki Misawa, Ilwhan Jang, Bhavna Kumar, Pavan K. Kommareddi, Thomas E. Carey, Thankam S. Nair, Toshihide Iwashita, Kiyoshi Misawa, Yukiko Iino

Publikováno v: Clinical Cancer Research. 15:2222-2230

Purpose: Galanin and its three receptors (GALR1-3) are expressed in many normal tissues, but silenced in some tumors. Contradictory roles for galanin and its receptors in various tumors have been reported. To understand their function, investigations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77a1324daa0c6370dab712f2c5b0996
https://doi.org/10.1158/1078-0432.ccr-08-2443

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Autor: Pavan K. Kommareddi, Su Hua Sha, Yehoash Raphael, Lisa A. Beyer, Thomas E. Carey, Maria M. Galano, Thankam S. Nair

Publikováno v: Hearing research. 282(1-2)

The membrane glycoprotein CTL2/SLC44A2 is expressed by supporting cells in the inner ear and has been identified as a target of antibodies that may induce auto-immune hearing loss. To determine if CTL2/SLC44A2 also has roles in inner ear development

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50914e6e496f8f012cbf3e2032a8f720
https://pubmed.ncbi.nlm.nih.gov/21986210

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Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells: activation of the extracellular signal regulated kinase pathway and induction of cyclin-dependent kinase inhibitors

Autor: Thankam S. Nair, Thomas E. Carey, Yo Ueda, T Tono, Kiyoshi Misawa, Pavan K. Kommareddi, Yuki Misawa, Takeharu Kanazawa, Toshihide Iwashita

Publikováno v: Oncogene. 26(39)

Galanin receptor 1 (GALR1) maps to a common region of 18q loss in head and neck squamous cell carcinomas and is frequently inactivated by methylation. To investigate effects of GALR1 and its signaling pathways, we stably expressed hemaglutinin-tagged

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ef690eaa12d65125a172aea474ce3b
https://pubmed.ncbi.nlm.nih.gov/17384686

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Identification and characterization of choline transporter-like protein 2, an inner ear glycoprotein of 68 and 72 kDa that is the target of antibody-induced hearing loss

Autor: H. Alexander Arts, Hussam K. El-Kashlan, Nickoleta L. Hoefling, Bulent Satar, Yehoash Raphael, Yo Ueda, Wayne E. Berryhill, Margaret I. Lomax, Pavan K. Kommareddi, Thankam S. Nair, Christopher D. Lansford, Thomas E. Carey, Kelley E. Kozma, Steven A. Telian, Tzy Wen Gong

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(7)

The Kresge Hearing Research Institute-3 (KHRI-3) antibody binds to a guinea pig inner ear supporting cell antigen (IESCA) and causes hearing loss. To gain insight into the mechanism of antibody-induced hearing loss, we used antibody immunoaffinity pu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b7b24f6034a3b049069be35c40aa2a
https://pubmed.ncbi.nlm.nih.gov/14973250

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Abstract 2720: Cidofovir modulates HPV E6 and E7 as well as p53, Rb and MDM2 in HPV16 naturally transformed head and neck squamous cell carcinoma and enhances chemosensitivity to Cisplatin

Autor: Sea-Yuong Jeon, Thomas E. Carey, Carol R. Bradford, Jung Je Park, Sang Yoon Kim, Thankam S. Nair, Pavan K. Kommareddi, Mark E. Prince, Ji Hyun Seo

Publikováno v: Cancer Research. 71:2720-2720

Purpose: The increasing incidence of oropharyngeal head and neck squamous cell carcinoma (HNSCC) is largely associated with sexually transmitted infection with high risk human papillomavirus (HPV), particularly HPV16. Cidofovir is an acyclic nucleosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28723da05f5d9d89f715ef3ba7f8f92f
https://doi.org/10.1158/1538-7445.am2011-2720

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