The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome.

Autor: Marín-Prida J; Center for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Havana, Cuba., Rodríguez-Ulloa A; Division of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba., Besada V; Division of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba.; China-Cuba Biotechnology Joint Innovation Center (CCBJIC), Yongzhou Zhong Gu Biotechnology Co. Ltd, Yongzhou, China., Llopiz-Arzuaga A; Division of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Department of Cellular Engineering and Biocatalysis , Institute of Biotechnology, National Autonomous University of Mexico (UNAM), Cuernavaca, Mexico., Batista NV; Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Hernández-González I; Department of Non-Clinical Research, Isotopes Center, San José de Las Lajas, Mayabeque, Cuba., Pavón-Fuentes N; Immunochemical Department, International Center for Neurological Restoration (CIREN), Havana, Cuba., Marciano Vieira ÉL; Translational Psychoneuroimmunology Group, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil., Falcón-Cama V; Division of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Departments of Physiological or Morphological Sciences, Latin American School of Medicine (ELAM), Havana, Cuba., Acosta EF; Department of Characterization, Center for Advanced Studies of Cuba, Havana, Cuba., Martínez-Donato G; Division of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba., Cervantes-Llanos M; Division of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba., Lingfeng D; China-Cuba Biotechnology Joint Innovation Center (CCBJIC), Yongzhou Zhong Gu Biotechnology Co. Ltd, Yongzhou, China., González LJ; Division of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba., Fernández-Massó JR; Division of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba., Guillén-Nieto G; Division of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Departments of Physiological or Morphological Sciences, Latin American School of Medicine (ELAM), Havana, Cuba., Pentón-Arias E; Division of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Departments of Physiological or Morphological Sciences, Latin American School of Medicine (ELAM), Havana, Cuba., Amaral FA; Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Teixeira MM; Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Pentón-Rol G; Division of Biomedical Research, Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Departments of Physiological or Morphological Sciences, Latin American School of Medicine (ELAM), Havana, Cuba.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Oct 23; Vol. 14, pp. 1227268. Date of Electronic Publication: 2023 Oct 23 (Print Publication: 2023).

Anti-inflammatory mechanisms and pharmacological actions of phycocyanobilin in a mouse model of experimental autoimmune encephalomyelitis: A therapeutic promise for multiple sclerosis.

Autor: Marín-Prida J; Center for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Havana, Cuba., Pavón-Fuentes N; Immunochemical Department, International Center for Neurological Restoration (CIREN), Havana, Cuba., Lagumersindez-Denis N; Institute of Neuropathology, University Medical Center Göttingen, Göttingen, Germany., Camacho-Rodríguez H; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba., García-Soca AM; Center for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Havana, Cuba., Sarduy-Chávez RC; Center for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Havana, Cuba., Vieira ÉLM; Translational Psychoneuroimmunology Group, School of Medicine, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil., Carvalho-Tavares J; Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil., Falcón-Cama V; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Latin American School of Medicine (ELAM), Havana, Cuba., Fernández-Massó JR; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba., Hernández-González I; Isotopes Center, San José de Las Lajas, Mayabeque, Cuba., Martínez-Donato G; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba., Guillén-Nieto G; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Latin American School of Medicine (ELAM), Havana, Cuba., Pentón-Arias E; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Latin American School of Medicine (ELAM), Havana, Cuba., Teixeira MM; Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Pentón-Rol G; Biomedical Research Department, Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Latin American School of Medicine (ELAM), Havana, Cuba.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Nov 03; Vol. 13, pp. 1036200. Date of Electronic Publication: 2022 Nov 03 (Print Publication: 2022).

Positive effects of Phycocyanobilin on gene expression in glutamate-induced excitotoxicity in SH-SY5Y cells and animal models of multiple sclerosis and cerebral ischemia.

Autor: Gardón DP; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/ 158 y 190, Cubanacán, Playa, Havana, PO Box 6162, Cuba.; China-Cuba Biotechnology Joint Innovation Center (CCBJIC), Yongzhou Zhong Gu Biotechnology Co., Ltd, Yangjiaqiao Street, Lengshuitan District, Yongzhou City 425000, Hunan Province, China., Cervantes-Llanos M; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/ 158 y 190, Cubanacán, Playa, Havana, PO Box 6162, Cuba., Matamoros BP; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/ 158 y 190, Cubanacán, Playa, Havana, PO Box 6162, Cuba., Rodríguez HC; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/ 158 y 190, Cubanacán, Playa, Havana, PO Box 6162, Cuba., Tan CY; China-Cuba Biotechnology Joint Innovation Center (CCBJIC), Yongzhou Zhong Gu Biotechnology Co., Ltd, Yangjiaqiao Street, Lengshuitan District, Yongzhou City 425000, Hunan Province, China., Marín-Prida J; Center for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Ave. 23 e/ 214 y 222, La Lisa. PO Box: 430, Havana, Cuba., Falcón-Cama V; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/ 158 y 190, Cubanacán, Playa, Havana, PO Box 6162, Cuba.; Latin American School of Medicine, Calle Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba., Pavón-Fuentes N; International Center for Neurological Restoration (CIREN), Havana, Cuba., Lemus JG; Faculty of Biology, University of Havana, Havana, Cuba., Ruiz LCB; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/ 158 y 190, Cubanacán, Playa, Havana, PO Box 6162, Cuba., Argudin TD; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/ 158 y 190, Cubanacán, Playa, Havana, PO Box 6162, Cuba., Donato GM; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/ 158 y 190, Cubanacán, Playa, Havana, PO Box 6162, Cuba.; China-Cuba Biotechnology Joint Innovation Center (CCBJIC), Yongzhou Zhong Gu Biotechnology Co., Ltd, Yangjiaqiao Street, Lengshuitan District, Yongzhou City 425000, Hunan Province, China., Perera Y; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/ 158 y 190, Cubanacán, Playa, Havana, PO Box 6162, Cuba.; China-Cuba Biotechnology Joint Innovation Center (CCBJIC), Yongzhou Zhong Gu Biotechnology Co., Ltd, Yangjiaqiao Street, Lengshuitan District, Yongzhou City 425000, Hunan Province, China., Yang K; China-Cuba Biotechnology Joint Innovation Center (CCBJIC), Yongzhou Zhong Gu Biotechnology Co., Ltd, Yangjiaqiao Street, Lengshuitan District, Yongzhou City 425000, Hunan Province, China., Pentón-Rol G; Center for Genetic Engineering and Biotechnology (CIGB), Ave. 31 e/ 158 y 190, Cubanacán, Playa, Havana, PO Box 6162, Cuba.; Latin American School of Medicine, Calle Panamericana Km 3 1/2, Playa, Havana, 11600, Cuba.

Publikováno v: Heliyon [Heliyon] 2022 Jun 20; Vol. 8 (6), pp. e09769. Date of Electronic Publication: 2022 Jun 20 (Print Publication: 2022).

Novel Insights into the Molecular Mechanisms Involved in the Neuroprotective Effects of C-Phycocyanin against Brain Ischemia in Rats.

Autor: Marín-Prida J; Center for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Havana, Cuba., Liberato JL; Faculty of Philosophy, Sciences and Literature of Ribeirão Preto, University of São Paulo, Brazil., Llópiz-Arzuaga A; Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Departamento de Ingeniería Celular y Biocatálisis, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Morelos, México., Stringhetta-Padovani K; Department of Clinical Analyses, Toxicology and Food Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil., Pavón-Fuentes N; International Center for Neurological Restoration, Havana, Cuba., Leopoldino AM; Department of Clinical Analyses, Toxicology and Food Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil., Cruz OG; Center for Genetic Engineering and Biotechnology, Havana, Cuba., González IH; Isotopes Center, Ave. Monumental Km 3.5, San José de Las Lajas, Mayabeque, Cuba., Pérez ML; Isotopes Center, Ave. Monumental Km 3.5, San José de Las Lajas, Mayabeque, Cuba., Camins A; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain.; Institute of Neuroscience, University of Barcelona, Barcelona, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Ferreira Dos Santos W; Faculty of Philosophy, Sciences and Literature of Ribeirão Preto, University of São Paulo, Brazil., Uyemura SA; Department of Clinical Analyses, Toxicology and Food Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil., Pardo-Andreu GL; Center for Research and Biological Evaluations, Institute of Pharmacy and Food, University of Havana, Havana, Cuba., Pentón-Rol G; Center for Genetic Engineering and Biotechnology, Havana, Cuba.; Latin American School of Medicine, Playa, Havana, Cuba.

Publikováno v: Current pharmaceutical design [Curr Pharm Des] 2022; Vol. 28 (14), pp. 1187-1197.

The Neuroprotective Role of Cyanobacteria with Focus on the Anti-Inflammatory and Antioxidant Potential: Current Status and Perspectives.

Autor: Rodrigues, Flávia¹ (AUTHOR) 10210253@ess.ipp.pt, Reis, Mariana² (AUTHOR) mreis@ciimar.up.pt, Ferreira, Leonor^2,3 (AUTHOR) lferreira@ciimar.up.pt, Grosso, Clara⁴ (AUTHOR) claragrosso@graq.isep.ipp.pt, Ferraz, Ricardo^1,5,6 (AUTHOR) rferraz@ess.ipp.pt, Vieira, Mónica^1,5 (AUTHOR) mav@ess.ipp.pt, Vasconcelos, Vitor^2,3 (AUTHOR) vmvascon@fc.up.pt, Martins, Rosário^1,2 (AUTHOR) mrm@ess.ipp.pt

Publikováno v: Molecules. Oct2024, Vol. 29 Issue 20, p4799. 23p.