Zobrazeno 1 - 10
of 2 963
pro vyhledávání: '"Paus, R."'
Adiponectin reportedly stimulates proliferation and elongation of human scalp hair follicles (HFs) ex vivo. In the current study, we investigated how adiponectin oligomers produced by perifollicular dermal white adipose tissue (dWAT), a potent source
Externí odkaz:
http://hdl.handle.net/10454/19738
Autor:
Nicu, C., O'Sullivan, J.D.B., Ramos, R., Timperi, L., Lai, T., Farjo, N., Farjo, B., Pople, J., Bhogal, R., Hardman, J.A., Plikus, M.V., Ansell, David, Paus, R.
Yes
Hair follicles (HFs) are immersed within dermal white adipose tissue (dWAT), yet human adipocyte-HF communication remains unexplored. Therefore, we investigated how perifollicular adipocytes affect the physiology of organ-cultured human anag
Hair follicles (HFs) are immersed within dermal white adipose tissue (dWAT), yet human adipocyte-HF communication remains unexplored. Therefore, we investigated how perifollicular adipocytes affect the physiology of organ-cultured human anag
Externí odkaz:
http://hdl.handle.net/10454/18343
Yes
Ex vivo wounded human skin organ culture is an invaluable tool for translationally relevant preclinical wound healing research. However, studies incorporating this system are still underutilized within the field because of the low throughput
Ex vivo wounded human skin organ culture is an invaluable tool for translationally relevant preclinical wound healing research. However, studies incorporating this system are still underutilized within the field because of the low throughput
Externí odkaz:
http://hdl.handle.net/10454/17786
Autor:
Clayton, R.W., Langan, E.A., Ansell, David, de Vos, I.J.H.M., Göbel, K., Schneider, M.R., Picardo, M., Lim, X., van Steensel, M.A.M., Paus, R.
The nervous system communicates with peripheral tissues through nerve fibres and the systemic release of hypothalamic and pituitary neurohormones. Communication between the nervous system and the largest human organ, skin, has traditionally received
Externí odkaz:
http://hdl.handle.net/10454/18341
Autor:
Imanishi, H., Answell, David M., Chéret, J., Harries, M., Bertolini, M., Sepp, N., Biro, T., Poblet, E., Jimenez, F., Hardman, J., Panicker, S.P., Ward, C.M., Paus, R.
Yes
Epithelial-to-mesenchymal transition (EMT) is critical for embryonic development and wound healing, and occurs in fibrotic disease and carcinoma. Here, we show that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of hu
Epithelial-to-mesenchymal transition (EMT) is critical for embryonic development and wound healing, and occurs in fibrotic disease and carcinoma. Here, we show that EMT also occurs within the bulge, the epithelial stem cell (eSC) niche of hu
Externí odkaz:
http://hdl.handle.net/10454/17809
Autor:
Stojadinovic, O., Wikramanayake, T.C., Villasante Fricke, A.C., Yin, N.C., Liang, L., Hinde, E., Escandon, J., Tomic-Canic, M., Ansell, David, Paus, R., Jimenez, J.J.
Yes
Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whet
Wound healing is a complex process regulated by various cell types and a plethora of mediators. While interactions between wounded skin and the hair follicles (HFs) could induce HF neogenesis or promote wound healing, it remains unknown whet
Externí odkaz:
http://hdl.handle.net/10454/17811
Yes
The cutaneous healing response has evolved to occur rapidly, in order to minimize infection and to re‐establish epithelial homeostasis. Rapid healing is achieved through complex coordination of multiple cell types, which importantly includ
The cutaneous healing response has evolved to occur rapidly, in order to minimize infection and to re‐establish epithelial homeostasis. Rapid healing is achieved through complex coordination of multiple cell types, which importantly includ
Externí odkaz:
http://hdl.handle.net/10454/17829
Autor:
Hardman, J.A., Tobin, Desmond J., Haslam, I.S., Farjo, N.P., Farjo, B.K., Al-Nuaimi, Y., Grimaldi, B., Paus, R.
Although the regulation of pigmentation is well characterized, it remains unclear whether cell-autonomous controls regulate the cyclic on–off switching of pigmentation in the hair follicle (HF). As human HFs and epidermal melanocytes express clock
Externí odkaz:
http://hdl.handle.net/10454/7429
Autor:
Kloepper, J.E., Baris, O.R., Reuter, K., Kobayash, K., Weiland, D., Vidali, S., Tobin, Desmond J., Niemann, C., Wiesner, R.J., Paus, R.
Here, we studied how epithelial energy metabolism impacts overall skin development by selectively deleting intraepithelial mtDNA in mice by ablating a key maintenance factor (TfamEKO), which induces loss of function of the electron transport chain (E
Externí odkaz:
http://hdl.handle.net/10454/7428
Hair loss can be a psychologically devastating adverse effect of chemotherapy, but satisfactory management strategies for chemotherapy-induced alopecia remain elusive. In this Review we focus on the complex pathobiology of this side-effect. We discus
Externí odkaz:
http://hdl.handle.net/10454/7224