Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Paurav B Desai"'
Autor:
Jan N Hansen, Fabian Kaiser, Philipp Leyendecker, Birthe Stüven, Jens‐Henning Krause, Fatemeh Derakhshandeh, Jaazba Irfan, Tommy J Sroka, Kenley M Preval, Paurav B Desai, Michael Kraut, Heidi Theis, Anna‐Dorothee Drews, Elena De‐Domenico, Kristian Händler, Gregory J Pazour, David J P Henderson, David U Mick, Dagmar Wachten
Publikováno v:
EMBO reports 23(8), e54315 (2022). doi:10.15252/embr.202154315
The primary cilium constitutes an organelle that orchestrates signal transduction independently from the cell body. Dysregulation of this intricate molecular architecture leads to severe human diseases, commonly referred to as ciliopathies. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9934eabf2a8b2287bb91c87707c6810e
https://doi.org/10.15252/embr.202154315
https://doi.org/10.15252/embr.202154315
Publikováno v:
Journal of Cell Biology. 220
The Hedgehog pathway, critical to vertebrate development, is organized in primary cilia. Activation of signaling causes the Hedgehog receptor Ptch1 to exit cilia, allowing a second receptor, Smo, to accumulate in cilia and activate the downstream ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9caec63fec4c19f50800a000d023a669
https://doi.org/10.1083/jcb.202010177
https://doi.org/10.1083/jcb.202010177
Publikováno v:
The Journal of Cell Biology
Hedgehog signaling involves the dynamic movement of receptors and effectors in and out of cilia. Desai et al. found that the dynamics of Smo are regulated by ubiquitination, which modulates its interaction with the intraflagellar transport system to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f3db37f5ac52765890e2d8cdb1baf8
http://europepmc.org/articles/PMC7337509
http://europepmc.org/articles/PMC7337509
Autor:
Michael W. Stuck, Gregory J. Pazour, Julie A. Jonassen, Jovenal T. San Agustin, Carlton M. Bates, Paurav B. Desai
Publikováno v:
Mechanisms of Development. 151:10-17
Eukaryotic cilia are assembled by intraflagellar transport (IFT) where large protein complexes called IFT particles move ciliary components from the cell body to the cilium. Defects in most IFT particle proteins disrupt ciliary assembly and cause mid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c845d68da7e532a609fff380d81092db
https://doi.org/10.1016/j.mod.2018.04.001
https://doi.org/10.1016/j.mod.2018.04.001
Publikováno v:
Cell Signal
Cellular Signalling
Cellular Signalling
Epithelial cells lining the ducts and tubules of the kidney nephron and collecting duct have a single non-motile cilium projecting from their surface into the lumen of the tubule. These organelles were long considered vestigial remnants left as a res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e85ec7de1eb6c07430c3608e3603697d
https://pubmed.ncbi.nlm.nih.gov/31881326
https://pubmed.ncbi.nlm.nih.gov/31881326
Genetic analysis in model organisms and human patient populations has revealed that a surprisingly large number of genes are needed to get axonemal dyneins into cilia, where they power the motility of these essential organelles. Most of these genes e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c18a994e234d04a7e34ef42ade330819
https://doi.org/10.1016/b978-0-12-809471-6.00004-8
https://doi.org/10.1016/b978-0-12-809471-6.00004-8
Autor:
Adam W. Avery, Gordon K. Chan, Anudariya B. Dean, Paurav B. Desai, Ian R. Gibbons, Thomas S. Hays, Edward H. Hinchcliffe, Yuqing Hou, Emily L. Hunter, Juyeon Hwang, Takashi Ishikawa, Rupam Jha, Ritsu Kamiya, Stephanie A. Ketcham, K. Kevin Pfister, Stephen M. King, Cody W. Lewis, Min-Gang Li, Richard J. McKenney, David R. Mitchell, Amanda L. Neisch, Mary E. Porter, Winfield S. Sale, Trina A. Schroer, Chikako Shingyoji, Thomas Surrey, Noriko Ueki, Richard B. Vallee, Kevin T. Vaughan, Ken-ichi Wakabayashi, Bill Wickstead, Maureen Wirschell, George B. Witman, Xin Xiang, Toshiki Yagi, Lionel Berthoux, Andrew P. Carter, Amrita Dawn, David J. Doobin, Mike Fainzilber, Elizabeth M.C. Fisher, Ken’ya Furuta, Veikko F. Geyer, Steven P. Gross, William O. Hancock, Kent L. Hill, Erika L.F. Holzbaur, Jonathon Howard, Simon Imhof, Kazuo Inaba, Frank Jülicher, Tarun M. Kapoor, Sandip Koley, Christine M. Lightcap, Niki T. Loges, Miroslav P. Milev, Hannah M. Mitchison, Armen J. Moughamian, Andrew J. Mouland, Kazuhiro Oiwa, Heymut Omran, Stephen H. Pilder, Michael Price, Babu J.N. Reddy, Hitoshi Sakakibara, Pablo Sartori, Helgo Schmidt, Miriam Schmidts, Amanda E. Siglin, Joseph H. Sisson, Jonathan B. Steinman, George T. Shubeita, Marco Terenzio, John B. Vincent, John C. Williams, Fan Yang, Xaojian Yao, Ahmet Yildiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a4fc3e596df0e76a7b86db619d9e001
https://doi.org/10.1016/b978-0-12-809471-6.01002-0
https://doi.org/10.1016/b978-0-12-809471-6.01002-0
Autor:
Adam W. Avery, Gordon K. Chan, Anudariya B. Dean, Paurav B. Desai, Ian R. Gibbons, Thomas S. Hays, Edward H. Hinchcliffe, Yuqing Hou, Emily L. Hunter, Juyeon Hwang, Takashi Ishikawa, Rupam Jha, Ritsu Kamiya, Stephanie A. Ketcham, K. Kevin Pfister, Stephen M. King, Cody W. Lewis, Min-Gang Li, Richard J. McKenney, David R. Mitchell, Amanda L. Neisch, Mary E. Porter, Winfield S. Sale, Trina A. Schroer, Chikako Shingyoji, Thomas Surrey, Noriko Ueki, Richard B. Vallee, Kevin T. Vaughan, Ken-ichi Wakabayashi, Bill Wickstead, Maureen Wirschell, George B. Witman, Xin Xiang, Toshiki Yagi, Lionel Berthoux, Andrew P. Carter, Amrita Dawn, David J. Doobin, Mike Fainzilber, Elizabeth M.C. Fisher, Ken’ya Furuta, Veikko F. Geyer, Steven P. Gross, William O. Hancock, Kent L. Hill, Erika L.F. Holzbaur, Jonathon Howard, Simon Imhof, Kazuo Inaba, Frank Jülicher, Tarun M. Kapoor, Sandip Koley, Christine M. Lightcap, Niki T. Loges, Miroslav P. Milev, Hannah M. Mitchison, Armen J. Moughamian, Andrew J. Mouland, Kazuhiro Oiwa, Heymut Omran, Stephen H. Pilder, Michael Price, Babu J.N. Reddy, Hitoshi Sakakibara, Pablo Sartori, Helgo Schmidt, Miriam Schmidts, Amanda E. Siglin, Joseph H. Sisson, Jonathan B. Steinman, George T. Shubeita, Marco Terenzio, John B. Vincent, John C. Williams, Fan Yang, Xaojian Yao, Ahmet Yildiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82a236daaba8e25fcc2782b8d71f1e4e
https://doi.org/10.1016/b978-0-12-809470-9.01002-x
https://doi.org/10.1016/b978-0-12-809470-9.01002-x
Publikováno v:
Cytoskeleton (Hoboken, N.j.)
The Chlamydomonas reinhardtii oda8 mutation blocks assembly of flagellar outer dynein arms (ODAs), and interacts genetically with ODA5 and ODA10, which encode axonemal proteins thought to aid dynein binding onto axonemal docking sites. We positionall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d030832d2e23f04e69c59eb0804451f6
http://europepmc.org/articles/PMC4361367
http://europepmc.org/articles/PMC4361367