Pathway-Guided Optimization of Deep Generative Molecular Design Models for Cancer Therapy

Autor: Qayyum, Alif Bin Abdul, Mertins, Susan D., Paulson, Amanda K., Urban, Nathan M., Yoon, Byung-Jun

The data-driven drug design problem can be formulated as an optimization task of a potentially expensive black-box objective function over a huge high-dimensional and structured molecular space. The junction tree variational autoencoder (JTVAE) has b

Externí odkaz: http://arxiv.org/abs/2411.03460

Utilization of Physical Therapy Prior to Consultation for Hip Preservation Surgery

Autor: Schaver, Andrew L., Khazi, Zain M., Paulson, Amanda C., Willey, Michael C., Westermann, Robert W.

Publikováno v: Iowa Orthop J

BACKGROUND: Comprehensive conservative care prior to arthroscopic hip surgery is recommended, but not all patients pursue a course of physical therapy (PT) prior to consulting a hip surgeon. The purpose of this study is to investigate the incidence a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::08f413b29d5288db989ee55526e373ca
https://europepmc.org/articles/PMC8662930/

The role of cell-cell interactions in population level dynamics of partial EMT states

Autor: Paulson, Amanda Kay

Publikováno v: Paulson, Amanda Kay. (2019). The role of cell-cell interactions in population level dynamics of partial EMT states. UC San Francisco: Biomedical Sciences. Retrieved from: http://www.escholarship.org/uc/item/3b1445jm

The epithelial-mesenchymal transition (EMT) plays a key role in invasion and metastasis. Recent studies have demonstrated that many discrete states exist along the EMT spectrum, with partial or hybrid EMT phenotypes as the most metastatic. These stat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::76b4e35e23252e3ed88d0223309f24f9
http://www.escholarship.org/uc/item/3b1445jm

Regulation of Mammary Stem/Progenitor Cells by PTEN/ Akt/β-Catenin Signaling.

Autor: Korkaya, Hasan¹ hkorkaya@med.umich.edu, Paulson, Amanda¹, Charafe-Jauffret, Emmanuelle², Ginestier, Christophe¹, Brown, Marty¹, Dutcher, Julie¹, Clouthier, Shawn G.¹, Wicha, Max S.¹

Publikováno v: PLoS Biology. Jun2009, Vol. 7 Issue 6, p1-14. 14p. 6 Color Photographs, 5 Black and White Photographs, 11 Graphs.

IL-6 and IL-8 stimulation of breast cancer stem cells contributes to trastuzumab resistance following PTEN deletion

Autor: Korkaya, Hasan, Davis, April, Gwangil Kim, Quraishi, Ahmet A., D’Angelo, Rosemarie, Paulson, Amanda K., Suling Liu, Tahra Luther, Clouthier, Shawn, Wicha, Max S.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17e03f2956c9cb9f4e8535f79ba26d89