Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Pauls, Henry W."'
Autor:
Laufer, Radoslaw, Ng, Grace, Liu, Yong, Patel, Narendra Kumar B., Edwards, Louise G., Lang, Yunhui, Li, Sze-Wan, Feher, Miklos, Awrey, Don E., Leung, Genie, Beletskaya, Irina, Plotnikova, Olga, Mason, Jacqueline M., Hodgson, Richard, Wei, Xin, Mao, Guodong, Luo, Xunyi, Huang, Ping, Green, Erin, Kiarash, Reza, Lin, Dan Chi-Chia, Harris-Brandts, Marees, Ban, Fuqiang, Nadeem, Vincent, Mak, Tak W., Pan, Guohua J., Qiu, Wei, Chirgadze, Nickolay Y., Pauls, Henry W.
Publikováno v:
In Bioorganic & Medicinal Chemistry 1 September 2014 22(17):4968-4997
Autor:
Li, Sze-Wan, Liu, Yong, Sampson, Peter B., Patel, Narendra Kumar, Forrest, Bryan T., Edwards, Louise, Laufer, Radoslaw, Feher, Miklos, Ban, Fuqiang, Awrey, Donald E., Hodgson, Richard, Beletskaya, Irina, Mao, Guodong, Mason, Jacqueline M., Wei, Xin, Luo, Xunyi, Kiarash, Reza, Green, Erin, Mak, Tak W., Pan, Guohua, Pauls, Henry W.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 October 2016 26(19):4625-4630
Autor:
Laufer, Radoslaw, Li, Sze-Wan, Liu, Yong, Ng, Grace, Lang, Yunhui, Feher, Miklos, Brokx, Richard, Beletskaya, Irina, Hodgson, Richard, Mao, Guodong, Plotnikova, Olga, Awrey, Donald E., Mason, Jacqueline M., Wei, Xin, Lin, Dan Chi-Chia, Che, Yi, Kiarash, Reza, Madeira, Brian, Fletcher, Graham C., Mak, Tak W., Bray, Mark R., Pauls, Henry W.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 August 2016 26(15):3562-3566
Autor:
Becker, Michael R., Ewing, William R., Davis, Roderick S., Pauls, Henry W., Ly, Cuong, Li, Aiwen, Mason, Helen J., Choi-Sledeski, Yong Mi, Spada, Alfred P., Chu, Valeria, Brown, Karen D., Colussi, Dennis J., Leadley, Robert J., Bentley, Ross, Bostwick, Jeff, Kasiewski, Charles, Morgan, Suzanne
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1999 9(18):2753-2758
Autor:
Nachum Kaplan, Judd Berman, Elias Bardouniotis, Jeremy Yethon, Barry Hafkin, Donald E. Awrey, Pauls Henry W
Publikováno v:
Journal of Chemotherapy (Florence, Italy)
AFN-1252 is a novel inhibitor of FabI, an essential enzyme in fatty acid biosynthesis in Staphylococcus spp. AFN-1252 exhibits typical MIC(90) values of ≤0·015 μg/ml against diverse clinical isolates of S. aureus, oral absorption, long eliminatio
Autor:
Elias Bardouniotis, Nachum Kaplan, Molly B. Schmid, Judd Berman, Donald E. Awrey, Rosanne Thalakada, Mandy Dorsey, Barry Hafkin, Monique Albert, Teresa E. Clarke, Jeremy Yethon, Vladimir Romanov, Pauls Henry W, Jaillal Ramnauth
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:5865-5874
The mechanism of action of AFN-1252, a selective inhibitor of Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI), which is involved in fatty acid biosynthesis, was confirmed by using biochemistry, macromolecular synthesis, genetics, an
Autor:
Nachum Kaplan, Vladimir Romanov, Pauls Henry W, Elias Bardouniotis, Teresa E. McGrath, Christine Picard, Dhushy Thambipillai, Andrew Leeson, Donald E. Awrey, Judd Berman, Peter Brent Sampson, Sean Handerson, Megan Domagala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5355-5358
Spiropiperidine naphthyridinone inhibitors of Staphylococcus aureus and Escherichia coli FabI have been prepared. Compounds 14a and 14c were identified as having sub-nanomolar E. coli FabI activity and are among the most potent FabI inhibitors yet de
Autor:
Michael Gardyan, Mathew Rose M, Jane Davidson, Joseph Romano, Alain Dupuy, Aldous Suzanne C, Jennifer Kwong, Sam S. Rebello, Jennifer Cairns, Odessa Giardino, Yongyi Luo, Sébastien Maignan, Andrew David Morley, Clive Mccarthy, Joseph T. Tsay, Darren Engers, Guyan Liang, Houille Olivier, Julian Levell, Pribish James R, Jean-Pierre Guilloteau, Garry Fenton, Simon Watson, Trevor K.P. Harrison, Peter C. Astles, Liduo Shen, Mark Czekaj, Gregory H. Merriman, Keith Sides, Pauls Henry W, Keith Smith, Jie Wang, Heng-Keang Lim, Paul R. Eastwood, Brian Whiteley
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:2859-2872
Tryptase is a serine protease found almost exclusively in mast cells. It has trypsin-like specificity, favoring cleavage of substrates with an arginine (or lysine) at the P1 position, and has optimal catalytic activity at neutral pH. Current evidence
Publikováno v:
Frontiers in Medicinal Chemistry - Online. 1:129-152
Autor:
Yong Mi Choi-Sledeski, Karen Brown, Robert J. Leadley, Gregory B. Poli, Vincent Mikol, Spada Alfred P, Yong Gong, Robert E. Kearney, Phillip Moxey, Charles J Kasiewski, Ross G. Bentley, Sébastien Maignan, Dennis Collussi, Pauls Henry W, Sam S. Rebello, Davis Roderick S, Valeria Chu, Gardner Charles J, Michael Becker, Jean-Pierre Guilloteau, Guyan Liang, Suzanne R Morgan
Publikováno v:
Journal of Medicinal Chemistry. 46:681-684
The discovery and SAR of ketopiperazino methylazaindole factor Xa inhibitors are described. Structure-activity data suggesting that this class of inhibitors does not bind in the canonical mode were confirmed by an X-ray crystal structure showing the