Zobrazeno 1 - 10 of 63 pro vyhledávání: '"Paulo W Pires"'
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Akademický článek
Brain endothelial cell TRPA1 channels initiate neurovascular coupling
Autor: Pratish Thakore, Michael G Alvarado, Sher Ali, Amreen Mughal, Paulo W Pires, Evan Yamasaki, Harry AT Pritchard, Brant E Isakson, Cam Ha T Tran, Scott Earley
Publikováno v: eLife, Vol 10 (2021)
Cerebral blood flow is dynamically regulated by neurovascular coupling to meet the dynamic metabolic demands of the brain. We hypothesized that TRPA1 channels in capillary endothelial cells are stimulated by neuronal activity and instigate a propagat
Externí odkaz: https://doaj.org/article/7b23c918a6444d5fb49cd757a865a485
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2
Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice
Autor: Jade A. Blackwell, Josiane F. Silva, Emma M. Louis, Andrea Savu, Tally M. Largent-Milnes, Heddwen L. Brooks, Paulo W. Pires
Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 323:H845-H860
Cerebral parenchymal arterioles from menopause mice showed increased myogenic tone. We identified an impairment in smooth muscle cell BKCa channel activity, without a reduction in endothelium-dependent dilation or nitric oxide production. Microvascul
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2731dbf0c5f8b8226f3b9d49617bf25
https://doi.org/10.1152/ajpheart.00276.2022
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3
Amyloid-β disrupts unitary calcium entry through endothelial NMDA receptors in mouse cerebral arteries
Autor: Paulo W. Pires, Allison M Kath, Michael T. Gee, Juliana L Sacoman, Emily C Peters, Felipe D Polk, Christopher J. Vance, Lukas N Pawlowski
Publikováno v: J Cereb Blood Flow Metab
Transient increases in intracellular Ca2+ activate endothelium-dependent vasodilatory pathways. This process is impaired in cerebral amyloid angiopathy, where amyloid- β(1-40) accumulates around blood vessels. In neurons, amyloid- β impairs the Ca2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32eb498ffc5811fd169e99168bd5230
https://doi.org/10.1177/0271678x211039592
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6
Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma
Autor: Md A, Hakim, Paulo W, Pires, Erik J, Behringer
Publikováno v: J Vis Exp
Cerebral blood flow is conveyed by vascular resistance arteries and downstream parenchymal arterioles. Steady-state vascular resistance to blood flow increases with decreasing diameter from arteries to arterioles that ultimately feed into capillaries
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199ef3f69633b9789627cb2bc0951278
https://doi.org/10.3791/63463-v
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Abstract P741: Elemental Calcium Influx Through Endothelial N-Methyl-D-Aspartate Receptors is Impaired by Acute Amyloid- β (1-40) in Cerebral Arteries
Autor: Emily C Peters, Paulo W. Pires, Allison M Kath, Michael T. Gee
Publikováno v: Stroke. 52
Introduction: Cerebral amyloid angiopathy (CAA), the accumulation of amyloid- β (1-40) (A β ) around cerebral arteries, impairs endothelial function. Endothelium-dependent dilation is a consequence of transient increases in intracellular [Ca 2+ ] i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b253b1ab003b014ecee69d6952a34845
https://doi.org/10.1161/str.52.suppl_1.p741
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