Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Paulo S Pinheiro"'
Autor:
Heidy N Medina, Karen E Callahan, Tulay Koru-Sengul, Sfurti Maheshwari, Qinran Liu, Neha Goel, Paulo S Pinheiro
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0268617 (2022)
BackgroundPostmenopausal breast cancer (PMBC) is the most commonly diagnosed and the second leading cause of cancer death among women in the US. Research examining the association between PMBC and education level has been inconsistent; no study in th
Externí odkaz:
https://doaj.org/article/c5f343f5ef8241abb1dbbb926ac1e4ca
Autor:
Bassam Tawfik, Joana S Martins, Sébastien Houy, Cordelia Imig, Paulo S Pinheiro, Sonja M Wojcik, Nils Brose, Benjamin H Cooper, Jakob Balslev Sørensen
Publikováno v:
eLife, Vol 10 (2021)
Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca2+-se
Externí odkaz:
https://doaj.org/article/b14cad5819734cfabd6b3cc3ade4bf26
Autor:
Ariana L Johnson, Heidy N Medina, Matthew P Schlumbrecht, Isildinha Reis, Erin N Kobetz, Paulo S Pinheiro
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0236402 (2020)
BackgroundEndometrial cancer (EC) mortality is particularly high among non-Hispanic Blacks and is twice that of non-Hispanic Whites. However, comparisons of EC survival outcomes by race/ethnicity are often confounded by histology and grade. Here, we
Externí odkaz:
https://doaj.org/article/e7c0bc6059a648fcb21b2544574d75da
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221337 (2019)
Colorectal cancer (CRC) is the third greatest cancer burden in the United States. The remarkably diverse Mountain West state of Nevada has uncharacteristically high CRC mortality compared to other Western states. We aimed to study the determinants of
Externí odkaz:
https://doaj.org/article/cdbbcf1a04674f8b8b2389df7e8e47b1
Autor:
Sébastien Houy, Alexander J Groffen, Iwona Ziomkiewicz, Matthijs Verhage, Paulo S Pinheiro, Jakob Balslev Sørensen
Publikováno v:
eLife, Vol 6 (2017)
Doc2B is a cytosolic protein with binding sites for Munc13 and Tctex-1 (dynein light chain), and two C2-domains that bind to phospholipids, Ca2+ and SNAREs. Whether Doc2B functions as a calcium sensor akin to synaptotagmins, or in other calcium-indep
Externí odkaz:
https://doaj.org/article/e23939c8ae6d4a2682d309f3e34a85e8
Autor:
Alexander M Walter, Rainer Müller, Bassam Tawfik, Keimpe DB Wierda, Paulo S Pinheiro, André Nadler, Anthony W McCarthy, Iwona Ziomkiewicz, Martin Kruse, Gregor Reither, Jens Rettig, Martin Lehmann, Volker Haucke, Bertil Hille, Carsten Schultz, Jakob Balslev Sørensen
Publikováno v:
eLife, Vol 6 (2017)
Phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] is essential for exocytosis. Classical ways of manipulating PI(4,5)P2 levels are slower than its metabolism, making it difficult to distinguish effects of PI(4,5)P2 from those of its metabolites. We d
Externí odkaz:
https://doaj.org/article/aabde6eab85749a18c97c983d851505d
Publikováno v:
Cancer Medicine, Vol 13, Iss 19, Pp n/a-n/a (2024)
Abstract Background Heterogeneous Black populations encounter significant obstacles in accessing cancer care, yet research on lung cancer treatment disparities remains limited. This study investigates whether the disparity in receiving curative‐int
Externí odkaz:
https://doaj.org/article/d3777d9708ca46fd9e989e2352d04584
Autor:
Kwun Nok M Man, Cordelia Imig, Alexander M Walter, Paulo S Pinheiro, David R Stevens, Jens Rettig, Jakob B Sørensen, Benjamin H Cooper, Nils Brose, Sonja M Wojcik
Publikováno v:
eLife, Vol 4 (2015)
It is currently unknown whether the molecular steps of large dense-core vesicle (LDCV) docking and priming are identical to the corresponding reactions in synaptic vesicle (SV) exocytosis. Munc13s are essential for SV docking and priming, and we syst
Externí odkaz:
https://doaj.org/article/4de6334245e149208696e8936eba3a24
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 12, p e1003362 (2013)
Neurotransmitter release depends on the fusion of secretory vesicles with the plasma membrane and the release of their contents. The final fusion step displays higher-order Ca(2+) dependence, but also upstream steps depend on Ca(2+). After deletion o
Externí odkaz:
https://doaj.org/article/cea08814fdff47f9a2f657288fe34dfd
Autor:
Aditi Dhir, Rachna Rahul, Qinran Liu, Dan Pham, Rachel Kronenfeld, Tulay Koru‐Sengul, Paulo S. Pinheiro
Publikováno v:
Cancer Medicine, Vol 13, Iss 8, Pp n/a-n/a (2024)
Abstract Background Ewing sarcoma (ES) is a malignant bone tumor most commonly affecting non‐Hispanic White (NHW) adolescent males, though recognition among Hispanic individuals is rising. Prior population‐based studies in the United States (US),
Externí odkaz:
https://doaj.org/article/95134193453d460781382067b50770f0