Perspectives for cancer immunotherapy mediated by p19Arf plus interferon-beta gene transfer

Autor: Bryan E. Strauss, Gissele Rolemberg Oliveira Silva, Igor de Luna Vieira, Otto Luiz Dutra Cerqueira, Paulo Roberto Del Valle, Ruan Felipe Vieira Medrano, Samir Andrade Mendonça

Publikováno v: Clinics, Vol 73, Iss suppl 1 (2018)

While cancer immunotherapy has gained much deserved attention in recent years, many areas regarding the optimization of such modalities remain unexplored, including the development of novel approaches and the strategic combination of therapies that t

Externí odkaz: https://doaj.org/article/9e494274f77b4c3394d29735776f8fce

Perfil transcricional de fibroblastos de tumor primário, linfonodo e medula óssea de pacientes com câncer de mama

Autor: Paulo Roberto Del Valle

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

Introdução: Em câncer de mama, existem evidências de que o microambiente pode influenciar o desenvolvimento do tumor no sítio primário, bem como em metástases regionais e a distância. Neste contexto, fibroblastos são importantes células est

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/5/5155/tde-26032013-143422/

Exploration of p53 plus interferon-beta gene transfer for the sensitization of human colorectal cancer cell lines to cell death

Autor: Rodrigo Esaki Tamura, Samir Andrade Mendonça, Fernanda Antunes, Bryan E. Strauss, Daniela B Zanatta, Aline Hunger, Paulo Roberto Del Valle

Publikováno v: Cancer Biol Ther

While treatments for colorectal cancer continue to improve, some 50% of patients succumb within 5 years, pointing to the need for additional therapeutic options. We have developed a modified non-replicating adenoviral vector for gene transfer, called

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963622a249b13befb65cb94876e927c8
https://doi.org/10.1080/15384047.2021.1899784

Intratumoral Immunization by p19Arf and Interferon-β Gene Transfer in a Heterotopic Mouse Model of Lung Carcinoma

Autor: Eugenia Costanzi-Strauss, Daniela B Zanatta, Ruan F.V. Medrano, Bryan E. Strauss, Guido Kroemer, João Paulo Portela Catani, Sandy Adjemian, Aline Hunger, Paulo Roberto Del Valle

Publikováno v: Translational Oncology
Translational Oncology, Elsevier, 2016, 9 (6), pp.565-574. ⟨10.1016/j.tranon.2016.09.011⟩
Translational Oncology, Elsevier, 2016, 9 (6), pp.565-574. 〈10.1016/j.tranon.2016.09.011〉
Translational Oncology, Vol 9, Iss 6, Pp 565-574 (2016)
Translational Oncology, 2016, 9 (6), pp.565-574. ⟨10.1016/j.tranon.2016.09.011⟩

International audience; Therapeutic strategies that act by eliciting and enhancing antitumor immunity have been clinically validated as an effective treatment modality but may benefit from the induction of both cell death and immune activation as pri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dabfa66cafe1c04287246fb9933d2f03
https://doi.org/10.1016/j.tranon.2016.09.011

Reestablishment of p53/Arf and interferon-β pathways mediated by a novel adenoviral vector potentiates antiviral response and immunogenic cell death

Autor: Daniela B Zanatta, Thiago A. Salles, Eugenia Costanzi-Strauss, Paulo Roberto Del Valle, Aline Hunger, Tatiane Katsue Furuya, Silvina Odete Bustos, Renata de Freitas Saito, Bryan E. Strauss, Daniel G. Ferrari, Ruan Fv Medrano, Christian A. Merkel

Publikováno v: Cell Death Discovery
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Late stage melanoma continues to be quite difficult to treat and new therapeutic approaches are needed. Since these tumors often retain wild-type p53 and have a strong immunogenic potential, we developed a gene transfer approach which targets these c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4feacedc796e060bba04ae4bbcf2d7d2
https://doi.org/10.1038/cddiscovery.2017.17