Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Paulo R R, Costa"'
Publikováno v:
Molecules, Vol 29, Iss 14, p 3420 (2024)
The (R,R)-Teth-TsDPEN-Ru(II) complex promoted the one-pot double C=O reduction of α-alkyl-β-ketoaldehydes through asymmetric transfer hydrogenation/dynamic kinetic resolution (ATH-DKR) under mild conditions. In this process, ten anti-2-benzyl-1-phe
Externí odkaz:
https://doaj.org/article/86fd507be1104d1fa9c0ae47677d00df
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1096-1140 (2021)
The synthesis of nitrogen-containing heterocycles, including natural alkaloids and other compounds presenting different types of biological activities have proved to be successful employing chiral sulfinyl imines derived from tert-butanesulfinamide.
Externí odkaz:
https://doaj.org/article/2d199ddf733843fa8d625d8ac0c04692
Autor:
Viviane dos Santos Faiões, Lívia C. R. M. da Frota, Edézio Ferreira Cunha-Junior, Julio C. F. Barcellos, Thayssa Da Silva, Chaquip Daher Netto, Silvia Amaral Gonçalves Da-Silva, Alcides J. M. da Silva, Paulo R. R. Costa, Eduardo Caio Torres-Santos
Publikováno v:
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-11 (2018)
Abstract Background Despite the development of new therapies for leishmaniasis, among the 200 countries or territories reporting to the WHO, 87 were identified as endemic for Tegumentary Leishmaniasis and 75 as endemic for Visceral Leishmaniasis. The
Externí odkaz:
https://doaj.org/article/c21f424e40fb4359a7e39bbe4c79cc09
Publikováno v:
SynOpen, Vol 01, Iss 01, Pp 0091-0096 (2017)
Abstract α-Aryl malonate and α-aryl cyano acetate moieties are found in the structures of many bioactive compounds. They are also key intermediates for the synthesis of many compounds such as isoflavonoids. In this work, we synthesized these compou
Externí odkaz:
https://doaj.org/article/4fcfadc4c1624775a7d805475425c58b
Autor:
Marcelo A Strauch, Marcelo Amorim Tomaz, Marcos Monteiro-Machado, Bruno Lemos Cons, Fernando Chagas Patrão-Neto, Jhonatha da Mota Teixeira-Cruz, Matheus da Silva Tavares-Henriques, Pâmella Dourila Nogueira-Souza, Sara L S Gomes, Paulo R R Costa, Edgar Schaeffer, Alcides J M da Silva, Paulo A Melo
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0211229 (2019)
BACKGROUND:It is known that local tissue injuries incurred by snakebites are quickly instilled causing extensive, irreversible, tissue destruction that may include loss of limb function or even amputation. Such injuries are not completely neutralized
Externí odkaz:
https://doaj.org/article/8d51574523bd4b3e9782f51c7d9ece63
Autor:
Guilherme S. Caleffi, Alice S. Rosa, Luana G. de Souza, João L. S. Avelar, Sarah M. R. Nascimento, Vitor M. de Almeida, Amanda R. Tucci, Vivian N. Ferreira, Alcides J. M. da Silva, Osvaldo A. Santos-Filho, Milene D. Miranda, Paulo R. R. Costa
Publikováno v:
Journal of Natural Products.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a2d737f3390a65fb34778e6cd04eba6
https://doi.org/10.1021/acs.jnatprod.3c00249
https://doi.org/10.1021/acs.jnatprod.3c00249
Publikováno v:
Organic Chemistry Frontiers. 9:1165-1194
In this review, we explore the applications of Asymmetric Hydrogenation (AH) and Asymmetric Transfer Hydrogenation (ATH) in the total synthesis of natural flavonoids and their analogues, highlighting the limitations and opportunities in the field.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3db2352fa9c1cd86851fe769e2b7eb6
https://doi.org/10.1039/d1qo01503f
https://doi.org/10.1039/d1qo01503f
Publikováno v:
ChemCatChem. 13:5097-5108
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88673d5dc8a22bdd515713cfe025eb22
https://doi.org/10.1002/cctc.202101252
https://doi.org/10.1002/cctc.202101252
Publikováno v:
The Journal of organic chemistry. 87(21)
The oxo-tethered-Ru(II) precatalyst promoted the one-pot C═C/C═O reduction of chalcones using sodium formate as the hydrogen source in water through asymmetric transfer hydrogenation. Twenty-seven 1,3-diarylpropan-1-ols were obtained in good to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a600b7f94bba3aae6a0a7b2a14455a2
https://pubmed.ncbi.nlm.nih.gov/36251770
https://pubmed.ncbi.nlm.nih.gov/36251770
Autor:
Eduardo Caio Torres-Santos, Débora de Souza Costa, Danyelle C. Santos, Valter Viana Andrade-Neto, Thaissa L. Silva, Marina Amaral Alves, Alan H. Fairlamb, Edézio Ferreira Cunha-Júnior, Paulo R. R. Costa, Marília O. F. Goulart, Ayres G. Dias, Susan Wyllie, Juliana da Silva Pacheco
Publikováno v:
ACS Med Chem Lett
[Image: see text] 5-Nitro-furan nitrones (1) and 5-nitro-thiophene nitrones (2) were synthesized in one step. Compounds 1a–c had the most potent leishmanicidal activity against intracellular amastigote forms of Leishmania amazonensis and L. infantu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36771859ab18b4684d9de6f221ab55bf
https://doi.org/10.1021/acsmedchemlett.1c00193
https://doi.org/10.1021/acsmedchemlett.1c00193