Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Paulo Pitasse-Santos"'
2
Akademický článek
2-Nitro-1-vinyl-1H-imidazole
Autor: Afonso Santine M. M. Velez, Gabriela Alves de Souza, Paulo Pitasse-Santos, Douglas Chaves de Alcântara Pinto, Debora Decote-Ricardo, Marco Edilson Freire de Lima
Publikováno v: Molbank, Vol 2022, Iss 1, p M1326 (2022)
Nitroimidazoles are pharmacophoric groups responsible for important antiparasitic activity against several infectious diseases. 2-Nitroimidazoles are found in some antiparasitic drugs and are one of the main moieties responsible for the biological ac
Externí odkaz: https://doaj.org/article/e3929b017f0048f2ac446435b4d76554
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3
Akademický článek
A Novel Protocol for the Synthesis of 1,2,4-Oxadiazoles Active against Trypanosomatids and Drug-Resistant Leukemia Cell Lines
Autor: Paulo Pitasse-Santos, Eduardo Salustiano, Raynná Bittencourt Pena, Otávio Augusto Chaves, Leonardo Marques da Fonseca, Kelli Monteiro da Costa, Carlos Antônio do Nascimento Santos, Jhenifer Santos Dos Reis, Marcos André Rodrigues da Costa Santos, Jose Osvaldo Previato, Lucia Mendonça Previato, Leonardo Freire-de-Lima, Nelilma Correia Romeiro, Lúcia Helena Pinto-da-Silva, Célio G. Freire-de-Lima, Débora Decotè-Ricardo, Marco Edilson Freire-de-Lima
Publikováno v: Tropical Medicine and Infectious Disease, Vol 7, Iss 12, p 403 (2022)
Cancer and parasitic diseases, such as leishmaniasis and Chagas disease, share similarities that allow the co-development of new antiproliferative agents as a strategy to quickly track the discovery of new drugs. This strategy is especially interesti
Externí odkaz: https://doaj.org/article/4cb9d0829caf4b10b3b7a55a9b082f65
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4
Akademický článek
Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant
Autor: Gabriela Alves de Souza, Soraia John da Silva, Catarina de Nigris Del Cistia, Paulo Pitasse-Santos, Lucas de Oliveira Pires, Yulli Moraes Passos, Yraima Cordeiro, Cristiane Martins Cardoso, Rosane Nora Castro, Carlos Mauricio R. Sant’Anna, Arthur Eugen Kümmerle
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 631-637 (2019)
A series of 3-substituted-7-aminoalcoxy-coumarin was designed and evaluated as cholinesterase inhibitors and antioxidants. All compounds were effective in inhibiting AChE with potencies in the nanomolar range. The 3-(4-(dimethylamino)phenyl)-7-aminoe
Externí odkaz: https://doaj.org/article/e9dead6f6ad94242a6049c23caa5acd4
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5
Peracetylation of polyphenols under rapid and mild reaction conditions
Autor: Douglas Chaves de Alcântara Pinto, Paulo Pitasse-Santos, Gabriela Alves de Souza, Rosane Nora Castro, Marco Edilson Freire de Lima
Structural modifications are an important tool for studying the properties of naturally occurring polyphenols. Regarding the preparation of acetyl esters, the presence of hydroxyl groups stabilized by intramolecular hydrogen bonds may pose an obstacl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4923b79761905bb40242a77fb6298f4a
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6
O POTENCIAL DA XANTONA NATURAL α-MANGOSTINA NO DESENVOLVIMENTO DE NOVOS AGENTES ANTI-INFECCIOSOS: UMA REVISÃO
Autor: Douglas Pinto, Gabriela de Souza, Paulo Pitasse-Santos, Afonso Velez, Debora Decote-Ricardo, Debora dos Santos, Leonardo Freire-de-Lima, Célio Freire-de-Lima, Marco de Lima
Publikováno v: Química Nova.
THE POTENTIAL OF NATURAL XANTHONE α-MANGOSTIN IN THE DEVELOPMENT OF NOVEL ANTIINFECTIVE AGENTS: A REVIEW. The mangosteen (Garcinia mangostana, Linn.) is a tropical fruit cultivated in the tropical forests of Southeast Asian countries. It is recogniz
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98544f42f1daa74307e43db2e6f23f67
https://doi.org/10.21577/0100-4042.20170954
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7
Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant
Autor: Paulo Pitasse-Santos, Yulli M. Passos, Rosane Nora Castro, Yraima Cordeiro, Soraia John da Silva, Carlos Mauricio R. Sant'Anna, Catarina de Nigris Del Cistia, Lucas de Oliveira Pires, Gabriela Alves de Souza, Arthur Eugen Kümmerle, Cristiane Martins Cardoso
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 631-637 (2019)
Journal of Enzyme Inhibition and Medicinal Chemistry
A series of 3-substituted-7-aminoalcoxy-coumarin was designed and evaluated as cholinesterase inhibitors and antioxidants. All compounds were effective in inhibiting AChE with potencies in the nanomolar range. The 3-(4-(dimethylamino)phenyl)-7-aminoe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a8ea7bf615aacfe4fcf1acaba5887c
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8
Effects of Cu(II) and Zn(II) coordination on the trypanocidal activities of curcuminoid-based ligands
Autor: Paulo Pitasse-Santos, Antônio Ricardo Moutinho Monteiro, Bianca Almeida da Silva, Debora Decote-Ricardo, Marco Edilson Freire de Lima, Amanda P. Neves, Roberta Katlen Fusco Marra, Ronny R. Ribeiro, Vitor Sueth-Santiago, Guilherme P. Guedes
Publikováno v: Inorganica Chimica Acta. 501:119237
Four heteroleptic metal complexes with the general formula [M(L1-2)(phen)Cl] 1a-b, 2a-b, (M = Cu(II) or Zn(II), L = curcuminoid ligand and phen = phenanthroline) have been prepared from the reaction of the ligands in the presence of Et3N with CuCl2·
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b05203128ec5de37ff0e5afc9bc95b6
https://doi.org/10.1016/j.ica.2019.119237
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9
1,2,4- and 1,3,4-Oxadiazoles as Scaffolds in the Development of Antiparasitic Agents
Autor: Marco Edilson Freire de Lima, Vitor Sueth-Santiago, Paulo Pitasse-Santos
Publikováno v: Journal of the Brazilian Chemical Society v.29 n.3 2018
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 29, Issue: 3, Pages: 435-456, Published: MAR 2018
In this review, we present the potential use of the heterocyclic oxadiazole rings in the design and synthesis of new drugs to treat parasitic infections. We intend to compare herein all the four isomeric forms of oxadiazole rings as well as discuss t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71cb9e1d8b05df001febd1ef4d5ae10
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532018000300435
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