Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Paulo Pinares-Garcia"'
Autor:
Paulo Pinares-Garcia, James Spyrou, Chaseley E. McKenzie, Ian C. Forster, Ming S. Soh, Erlina Mohamed Syazwan, Mohammed Atif, Christopher A. Reid
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Changes in Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) channel function have been linked to depressive-like traits, making them potential drug targets. However, there is currently no peer-reviewed data supporting the use of a small mole
Externí odkaz:
https://doaj.org/article/aa5cc88cc33c4b32b0f7f64ecf6c597e
Publikováno v:
eLife, Vol 11 (2022)
A neural pathway involved in goal-oriented behaviours becomes dysregulated during binge drinking and alcohol use disorder.
Externí odkaz:
https://doaj.org/article/3c3a2de1cb054992aca40ba703dd1a4f
Publikováno v:
Brain Sciences, Vol 8, Iss 8, p 154 (2018)
Males and females sometimes significantly differ in their propensity to develop neurological disorders. Females suffer more from mood disorders such as depression and anxiety, whereas males are more susceptible to deficits in the dopamine system incl
Externí odkaz:
https://doaj.org/article/6f3121809a31404183a8a413ce338267
Autor:
Da Zhao, Paulo Pinares-Garcia, Chaseley E. McKenzie, Lauren E. Bleakley, Ian C. Forster, Vickie H.Y. Wong, Christine T.O. Nguyen, Ingrid E. Scheffer, Christopher A. Reid, Bang V. Bui
Publikováno v:
The Journal of Neuroscience. 43:2199-2209
Pathogenic variants inHCN1are associated with a range of epilepsy syndromes including a developmental and epileptic encephalopathy. The recurrentde novo HCN1pathogenic variant (M305L) results in a cation leak, allowing the flux of excitatory ions at
Autor:
Seungmin Ham, Eric Vilain, Vincent R. Harley, Joohyung Lee, Paulo Pinares-Garcia, Hannah Loke
Publikováno v:
Proceedings of the National Academy of Sciences. 116:16577-16582
Parkinson’s disease (PD) is a debilitating neurodegenerative disorder caused by the loss of midbrain dopamine (DA) neurons. While the cause of DA cell loss in PD is unknown, male sex is a strong risk factor. Aside from the protective actions of sex
Autor:
Ian C. Forster, Leonid Churilov, Samuel F. Berkovic, Snezana Maljevic, Ingrid E. Scheffer, Nikola Jancovski, Ming S Soh, Bina Santoro, Anirudh Kathirvel, Lauren E Bleakley, Christopher A. Reid, Alicia Sedo, Paulo Pinares-Garcia, Chaseley E McKenzie, Steven Petrou
Publikováno v:
Brain : a journal of neurology. 144(7)
Pathogenic variants in HCN1 are associated with developmental and epileptic encephalopathies. The recurrent de novo HCN1 M305L pathogenic variant is associated with severe developmental impairment and drug-resistant epilepsy. We engineered the homolo
Publikováno v:
Epilepsy research. 168
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been implicated in the pathogenesis of epilepsy and consequently as targets for anticonvulsant drugs. Consistent with this, broad-spectrum block of HCN-mediated current (Ih) redu
Publikováno v:
Brain Sciences
Brain Sciences, Vol 8, Iss 8, p 154 (2018)
Brain Sciences, Vol 8, Iss 8, p 154 (2018)
Males and females sometimes significantly differ in their propensity to develop neurological disorders. Females suffer more from mood disorders such as depression and anxiety, whereas males are more susceptible to deficits in the dopamine system incl