Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Paulo M M Guedes"'
Autor:
Tiago L M Sanches, Larissa D Cunha, Grace K Silva, Paulo M M Guedes, João Santana Silva, Dario S Zamboni
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e91640 (2014)
Chagas disease develops upon infection with the protozoan parasite Trypanosoma cruzi and undergoes an acute phase characterized by massive parasite replication and the presence of parasites in the blood. This condition is known as acute phase parasit
Externí odkaz:
https://doaj.org/article/b8f562e74ed1475888529fc5be0ba52b
Autor:
Ramon F Santos, Marcela A S Pôssa, Matheus S Bastos, Paulo M M Guedes, Márcia R Almeida, Ricardo Demarco, Sergio Verjovski-Almeida, Maria T Bahia, Juliana L R Fietto
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 3, Iss 3, p e387 (2009)
BACKGROUND: The protozoan Trypanosoma cruzi is the causative agent of Chagas disease. There are no vaccines or effective treatment, especially in the chronic phase when most patients are diagnosed. There is a clear necessity to develop new drugs and
Externí odkaz:
https://doaj.org/article/a8d99befaac34ab390d7d8799fdc429c
Autor:
Alessandra M M, Lucena, Cássio R M, Souza, Jéssica T, Jales, Paulo M M, Guedes, George E C, de Miranda, Adolpho M A, de Moura, João X, Araújo-Júnior, George J, Nascimento, Kátia C, Scortecci, Barbara V O, Santos, Janeusa T, Souto
Publikováno v:
Marine Drugs
Caulerpin (CLP), an alkaloid from algae of the genus Caulerpa, has shown anti-inflammatory activity. Therefore, this study aimed to analyze the effect of CLP in the murine model of peritonitis and ulcerative colitis. Firstly, the mice were submitted
Autor:
Paulo M M, Guedes, Fabiana S, Oliveira, Fredy R S, Gutierrez, Grace Kelly, da Silva, Gerson Jhonatan, Rodrigues, Lusiane Maria, Bendhack, Douglas W, Franco, Maria A, Do Valle Matta, Dario S, Zamboni, Roberto Santana, da Silva, João Santana, Silva
Benznidazole (Bz) is the therapy currently available for clinical treatment of Chagas' disease. However, many strains of Trypanosoma cruzi parasites are naturally resistant. Nitric oxide (NO) produced by activated macrophages is crucial to the intrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f5db6d568ecc2a5deb896e279cd99996
https://europepmc.org/articles/PMC2874850/
https://europepmc.org/articles/PMC2874850/
Autor:
Daniela A, D'Avila, Paulo M M, Guedes, Ana M, Castro, Eliane D, Gontijo, Egler, Chiari, Lúcia M C, Galvão
Publikováno v:
Memorias do Instituto Oswaldo Cruz. 104(1)
The immune response is crucial for protection against disease; however, immunological imbalances can lead to heart and digestive tract lesions in chagasic patients. Several studies have evaluated the cellular and humoral immune responses in chagasic
Autor:
Marta de Lana, Maria Terezinha Bahia, André Talvani, George Luiz Lins Machado-Coelho, Paulo M. M. Guedes, Daniela Maria dos Santos
Publikováno v:
Experimental parasitology. 121(1)
The clonal evolution model postulated for Trypanosoma cruzi predicts a correlation between the phylogenetic divergence of T. cruzi clonal genotypes and their biological properties. In the present study, the linkage between phylogenetic divergence of
Autor:
Paulo M M, Guedes, Vanja M, Veloso, Marcelo V, Caliari, Cláudia M, Carneiro, Sheler M, Souza, Marta, de Lana, Egler, Chiari, Maria T, Bahia, Lúcia M C, Galvão
Publikováno v:
Memorias do Instituto Oswaldo Cruz. 102(2)
Trypanosoma cruzi is a hemoflagelate parasite associated with heart dysfunctions causing serious problems in Central and South America. Beagle dogs develop the symptoms of Chagas disease in humans, and could be an important experimental model for bet