On the Offensive: the Role of Outer Membrane Vesicles in the Successful Dissemination of New Delhi Metallo-β-lactamase (NDM-1)

Autor: Alejandro J Vila, Lisandro J González, Melina María Belén Martínez, Robert A. Bonomo, Paulo Cesar Maffia

Publikováno v: mBio
mBio, Vol 12, Iss 5 (2021)

The emergence and worldwide dissemination of carbapenemase-producing Gram-negative bacteria are a major public health threat. Metallo-β-lactamases (MBLs) represent the largest family of carbapenemases. Regrettably, these resistance determinants are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e06cd395f01146b31f07efd6a87fceb8
https://doi.org/10.1128/mbio.01836-21

Fast Biofilm Penetration and Anti-PAO1 Activity of Nebulized Azithromycin in Nanoarchaeosomes

Autor: Eder Lilia Romero, Paulo Cesar Maffia, Barbara Malheiros, Melina María Belén Martínez, Maria Jose Morilla, María Julia Altube, Leandro R.S. Barbosa

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Azithromycin (AZ) is a broad-spectrum antibiotic with anti-inflammatory and antiquorum sensing activity against biofilm forming bacteria such as Pseudomonas aeruginosa. AZ administered by oral or parenteral routes, however, neither efficiently access

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fda210c892d7daca5de558554dd21d
https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.9b00721

Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses

Autor: Axel Hollmann, Juan Carlos Espeche, Paulo Cesar Maffia, Nancy Patricia Cardoso

Publikováno v: Peptides. 142:170570

Viruses remain one of the leading causes of animal and human disease. Some animal viral infections spread sporadically to human populations, posing a serious health risk. Particularly the emerging viral zoonotic diseases such as the novel, zoonotic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c3a4ed0fa6f6bd66bf30b54841dc7e
https://doi.org/10.1016/j.peptides.2021.170570

Antibacterial, anti-biofilm and in vivo activities of the antimicrobial peptides P5 and P6.2

Autor: Axel Polizzotto, Paulo Cesar Maffia, Melina María Belén Martínez, Naiquén Flores, Liliana Semorile

Publikováno v: Microbial pathogenesis. 139

Cationic antimicrobial peptides (AMPs) are short linear amino acid sequences, which display antimicrobial activity against a wide range of bacterial species. They are promising novel antimicrobials since they have shown bactericidal effects against m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4190415e49874f502f950ff0f1a039
https://pubmed.ncbi.nlm.nih.gov/31778756

Unravelling the mechanism of action of 'de novo' designed peptide P1 with model membranes and gram-positive and gram-negative bacteria

Autor: Axel Hollmann, Patricia del Valle Maturana, Paulo Cesar Maffia, Andrea Carmen Cutró, Liliana Semorile, Juan Carlos Espeche, Melina María Belén Martínez

Publikováno v: Archives of Biochemistry and Biophysics. 693:108549

In the last years, the decreasing effectiveness of conventional antimicrobial-drugs has caused serious problems due to the rapid emergence of multidrug-resistant pathogens. This situation has brought attention to other antimicrobial agents like antim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9875d471c2c3695bd0dbae6226f3acca
https://doi.org/10.1016/j.abb.2020.108549