Infecções por papilomavírus humano e neoplasia do colo uterino: efeito do polimorfismo dos genes HLA-DRB1 E -DQB1 e respostas linfoproliferativas contra peptídeos virais

Autor: Paulo Cesar Maciag

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

Infecção persistente por tipos oncogênicos de papilomavírus humano (HPV) é considerada como o principal fator de risco para desenvolvimento de carcinoma invasivo do colo uterino (CCU) e de lesões intraepiteliais cervicais (SIL). Fatores genéti

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/46/46131/tde-31082018-143208/

Data from Cancer Immunotherapy Targeting the High Molecular Weight Melanoma-Associated Antigen Protein Results in a Broad Antitumor Response and Reduction of Pericytes in the Tumor Vasculature

Autor: Yvonne Paterson, Soldano Ferrone, Zhen-Kun Pan, Matthew M. Seavey, Paulo Cesar Maciag

The high molecular weight melanoma-associated antigen (HMW-MAA), also known as melanoma chondroitin sulfate proteoglycan, has been used as a target for the immunotherapy of melanoma. This antigen is expressed on the cell surface and has a restricted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5857c4f8c5182c3ecc38c2eb3b3e79db
https://doi.org/10.1158/0008-5472.c.6497282

Deregulated Expression of Superoxide Dismutase-2 Correlates with Different Stages of Cervical Neoplasia

Autor: Lara Termini, Adhemar Longatto Filho, Paulo Cesar Maciag, Daniela Etlinger, Venâncio Avancini Ferreira Alves, Suely Nonogaki, Fernando Augusto Soares, Luisa Lina Villa

Publikováno v: Disease markers
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Disease Markers, Vol 30, Iss 6, Pp 275-281 (2011)

We are grateful to Carlos Ferreira do Nascimento and Severino Ferreira from the Hospital A.C. Camargo for technical assistance. We would like to thank Dr. Enrique Boccardo, Dr. Ismar Haga and Dr. Ana Paula Lepique for critical review of the manuscrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6774dc4a96218f84f92288f2af082b4e
http://europepmc.org/articles/PMC3825245

The first clinical use of a live-attenuated Listeria monocytogenes vaccine: A Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix

Autor: Paulo Cesar Maciag, Siniša Radulović, John Rothman

Publikováno v: Vaccine. 27:3975-3983

Invasive carcinoma of the cervix (ICC) is the second most common cancer in women worldwide. Lm -LLO-E7 vaccine is a live-attenuated Listeria monocytogenes ( Lm ) that secretes the HPV-16 E7 antigen fused to a non-hemolytic fragment of the Lm protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c8c3842da2c3ec9a329c41eaf0ed25
https://doi.org/10.1016/j.vaccine.2009.04.041

A Novel Human Her-2/neu Chimeric Molecule Expressed byListeria monocytogenesCan Elicit Potent HLA-A2 Restricted CD8-positive T cell Responses and Impact the Growth and Spread of Her-2/neu-positive Breast Tumors

Autor: Yvonne Paterson, Matthew M. Seavey, Vafa Shahabi, Paulo Cesar Maciag, Anu Wallecha, Sandra Rivera, Zhen-Kun Pan

Publikováno v: Clinical Cancer Research. 15:924-932

Purpose: The aim of this study was to efficiently design a novel vaccine for human Her-2/neu-positive (hHer-2/neu) breast cancer using the live, attenuated bacterial vector Listeria monocytogenes.Experimental Design: Three recombinant L. monocytogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5cc88614ea8e7c54eaa607627caa24
https://doi.org/10.1158/1078-0432.ccr-08-2283