Zobrazeno 1 - 10
of 242
pro vyhledávání: '"Paulo C. Rodriguez"'
Autor:
Alyssa N. Obermayer, Darwin Chang, Gabrielle Nobles, Mingxiang Teng, Aik-Choon Tan, Xuefeng Wang, Y. Ann Chen, Steven Eschrich, Paulo C. Rodriguez, G. Daniel Grass, Soheil Meshinchi, Ahmad Tarhini, Dung-tsa Chen, Timothy I. Shaw
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Pathway-level survival analysis offers the opportunity to examine molecular pathways and immune signatures that influence patient outcomes. However, available survival analysis algorithms are limited in pathway-level function and lack a stre
Externí odkaz:
https://doaj.org/article/a8a184167ea846a0a4bc7b36d14d1a13
Autor:
Nada H. Eisa, Vincent M. Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A. Serwetnyk, Taoufik Llbiyi, Sumin Lu, Kashish Kainth, Yasmeen Jilani, Daniela Marasco, Abdeljabar El Andaloussi, Sukyeong Lee, Francis T.F. Tsai, Paulo C. Rodriguez, David Munn, Esteban Celis, Hasan Korkaya, Abdessamad Debbab, Brian Blagg, Ahmed Chadli
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108308- (2023)
Summary: Low response rates and immune-related adverse events limit the remarkable impact of cancer immunotherapy. To improve clinical outcomes, preclinical studies have shown that combining immunotherapies with N-terminal Hsp90 inhibitors resulted i
Externí odkaz:
https://doaj.org/article/f4ba062b1eb84919b99e30fb877c3d61
Autor:
Maria Dulfary Sanchez-Pino, William S. Richardson, Jovanny Zabaleta, Ramesh Thylur Puttalingaiah, Andrew G. Chapple, Jiao Liu, Yonghyan Kim, Michelle Ponder, Randi DeArmitt, Lyndsey Buckner Baiamonte, Dorota Wyczechowska, Liqin Zheng, Amir A. Al-Khami, Jone Garai, Rachel Martini, Melissa Davis, Jessica Koller Gorham, James B. Wooldridge, Paulo C. Rodriguez, Lucio Miele, Augusto C. Ochoa
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103910- (2022)
Summary: Background: Low-density neutrophils (LDN) are increased in several inflammatory diseases and may also play a role in the low-grade chronic inflammation associated with obesity. Here we explored their role in obesity, determined their gene si
Externí odkaz:
https://doaj.org/article/4873f6cb4f564de8931064266165af9b
Autor:
Miao Yu, Gang Guo, Lei Huang, Libin Deng, Chang-Sheng Chang, Bhagelu R. Achyut, Madison Canning, Ningchun Xu, Ali S. Arbab, Roni J. Bollag, Paulo C. Rodriguez, Andrew L. Mellor, Huidong Shi, David H. Munn, Yan Cui
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Our understanding on how CAFs can be activated to support tumour progression is still limited. Here, the authors demonstrate that adenosine produced in the tumour microenvironment can enhance the expression of CD73 in CAFs ultimately driving CD8 T-Ce
Externí odkaz:
https://doaj.org/article/3a939ed9e1ba46adb3d1e889423e5b4d
Autor:
Yu Cao, Jimena Trillo-Tinoco, Rosa A. Sierra, Carmen Anadon, Wenjie Dai, Eslam Mohamed, Ling Cen, Tara L. Costich, Anthony Magliocco, Douglas Marchion, Richard Klar, Sven Michel, Frank Jaschinski, Richard R. Reich, Shikhar Mehrotra, Juan R. Cubillos-Ruiz, David H. Munn, Jose R. Conejo-Garcia, Paulo C. Rodriguez
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
T-cell function impairment is one of the major determinants of tumour immune evasion. Here, the authors show that the hostile conditions in the tumour microenvironment lead to C/EBP homologous-protein upregulation in T cells via ER stress, resulting
Externí odkaz:
https://doaj.org/article/f05c7d9780cc4100b5638fc324c1bb21
Autor:
Claudia Sorrentino, Fokhrul Hossain, Paulo C. Rodriguez, Rosa A. Sierra, Antonio Pannuti, Stephen Hatfield, Barbara A. Osborne, Lisa M. Minter, Lucio Miele, Silvana Morello
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Externí odkaz:
https://doaj.org/article/241eb176dc6b4d0f96316fe01988e3c4
Autor:
Claudia Sorrentino, Fokhrul Hossain, Paulo C. Rodriguez, Rosa A. Sierra, Antonio Pannuti, Stephen Hatfield, Barbara A. Osborne, Lisa M. Minter, Lucio Miele, Silvana Morello
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Notch receptors signaling is required for optimal T-cell activation and function. T-cell receptor (TCR) engagement can activate Notch receptors in T-cells in a ligand-independent fashion. In this study, we examined the role of adenosine A2A receptor
Externí odkaz:
https://doaj.org/article/03798900c2a24384a59550c33bc67f4b
Autor:
Brian C. Betts, Frederick L. Locke, Elizabeth M. Sagatys, Joseph Pidala, Kelly Walton, Meghan Menges, Jordan Reff, Asim Saha, Julie Y. Djeu, John V. Kiluk, Marie C. Lee, Jongphil Kim, Chang Won Kang, Chih-Hang Anthony Tang, Jeremy Frieling, Conor C. Lynch, Alan List, Paulo C. Rodriguez, Bruce R. Blazar, Jose R. Conejo-Garcia, Juan R. Del Valle, Chih-Chi Andrew Hu, Claudio Anasetti
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Acute graft- vs. -host disease (GVHD) is an important cause of morbidity and death after allogeneic hematopoietic cell transplantation (HCT). We identify a new approach to prevent GVHD that impairs monocyte-derived dendritic cell (moDC) alloactivatio
Externí odkaz:
https://doaj.org/article/d7d53dab35a0449b90de1bf45bb8064e
Autor:
Vincenzo Bronte, Sven Brandau, Shu-Hsia Chen, Mario P. Colombo, Alan B. Frey, Tim F. Greten, Susanna Mandruzzato, Peter J. Murray, Augusto Ochoa, Suzanne Ostrand-Rosenberg, Paulo C. Rodriguez, Antonio Sica, Viktor Umansky, Robert H. Vonderheide, Dmitry I. Gabrilovich
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Abstract Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both
Externí odkaz:
https://doaj.org/article/7c32c093ca484097b5efdfd00dee7e64
Autor:
Fokhrul Hossain, Samarpan Majumder, Deniz A. Ucar, Paulo C. Rodriguez, Todd E. Golde, Lisa M. Minter, Barbara A. Osborne, Lucio Miele
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Cancer immunotherapy, which stimulates or augments host immune responses to treat malignancies, is the latest development in the rapidly advancing field of cancer immunology. The basic principles of immunotherapies are either to enhance the functions
Externí odkaz:
https://doaj.org/article/43007cad3d39406fad720a3813534bd6