Zobrazeno 1 - 10
of 280
pro vyhledávání: '"Paulo C. Rodriguez"'
Autor:
Alyssa N. Obermayer, Darwin Chang, Gabrielle Nobles, Mingxiang Teng, Aik-Choon Tan, Xuefeng Wang, Y. Ann Chen, Steven Eschrich, Paulo C. Rodriguez, G. Daniel Grass, Soheil Meshinchi, Ahmad Tarhini, Dung-tsa Chen, Timothy I. Shaw
Publikováno v:
BMC Bioinformatics, Vol 24, Iss 1, Pp 1-14 (2023)
Abstract Pathway-level survival analysis offers the opportunity to examine molecular pathways and immune signatures that influence patient outcomes. However, available survival analysis algorithms are limited in pathway-level function and lack a stre
Externí odkaz:
https://doaj.org/article/a8a184167ea846a0a4bc7b36d14d1a13
Autor:
Paulo C Rodriguez, Zhihua Chen, Y Ann Chen, Lilit Karapetyan, Jiannong Li, Manali S Phadke, Jessica K Mandula, Peter A Forsyth, Keiran S M Smalley
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 12 (2023)
Background Although the anti-PD-1+LAG-3 and the anti-PD-1+CTLA-4 combinations are effective in advanced melanoma, it remains unclear whether their mechanisms of action overlap.Methods We used single cell (sc) RNA-seq, flow cytometry and IHC analysis
Externí odkaz:
https://doaj.org/article/4d56c2e227884da39b33d1663c170b41
Autor:
Nada H. Eisa, Vincent M. Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A. Serwetnyk, Taoufik Llbiyi, Sumin Lu, Kashish Kainth, Yasmeen Jilani, Daniela Marasco, Abdeljabar El Andaloussi, Sukyeong Lee, Francis T.F. Tsai, Paulo C. Rodriguez, David Munn, Esteban Celis, Hasan Korkaya, Abdessamad Debbab, Brian Blagg, Ahmed Chadli
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108308- (2023)
Summary: Low response rates and immune-related adverse events limit the remarkable impact of cancer immunotherapy. To improve clinical outcomes, preclinical studies have shown that combining immunotherapies with N-terminal Hsp90 inhibitors resulted i
Externí odkaz:
https://doaj.org/article/f4ba062b1eb84919b99e30fb877c3d61
Autor:
Xuefeng Wang, Igor Puzanov, Abdul Rafeh Naqash, Paulo C Rodriguez, George J Weiner, Jose Conejo-Garcia, Jamie Teer, Xiaoqing Yu, Margaret E Gatti-Mays, William Dalton, Howard Colman, Aik Choon Tan, Timothy I Shaw, Darwin Chang, Alyssa Obermayer, Dale Hedges, Aakrosh Ratan, Martin D McCarter, John Carpten, Susanne M Arnold, Michelle Churchman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/0258ce1216ab4d38926536bfebfd3189
Autor:
Maria Dulfary Sanchez-Pino, William S. Richardson, Jovanny Zabaleta, Ramesh Thylur Puttalingaiah, Andrew G. Chapple, Jiao Liu, Yonghyan Kim, Michelle Ponder, Randi DeArmitt, Lyndsey Buckner Baiamonte, Dorota Wyczechowska, Liqin Zheng, Amir A. Al-Khami, Jone Garai, Rachel Martini, Melissa Davis, Jessica Koller Gorham, James B. Wooldridge, Paulo C. Rodriguez, Lucio Miele, Augusto C. Ochoa
Publikováno v:
EBioMedicine, Vol 77, Iss , Pp 103910- (2022)
Summary: Background: Low-density neutrophils (LDN) are increased in several inflammatory diseases and may also play a role in the low-grade chronic inflammation associated with obesity. Here we explored their role in obesity, determined their gene si
Externí odkaz:
https://doaj.org/article/4873f6cb4f564de8931064266165af9b
Autor:
Miao Yu, Gang Guo, Lei Huang, Libin Deng, Chang-Sheng Chang, Bhagelu R. Achyut, Madison Canning, Ningchun Xu, Ali S. Arbab, Roni J. Bollag, Paulo C. Rodriguez, Andrew L. Mellor, Huidong Shi, David H. Munn, Yan Cui
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Our understanding on how CAFs can be activated to support tumour progression is still limited. Here, the authors demonstrate that adenosine produced in the tumour microenvironment can enhance the expression of CD73 in CAFs ultimately driving CD8 T-Ce
Externí odkaz:
https://doaj.org/article/3a939ed9e1ba46adb3d1e889423e5b4d
Autor:
Yu Cao, Jimena Trillo-Tinoco, Rosa A. Sierra, Carmen Anadon, Wenjie Dai, Eslam Mohamed, Ling Cen, Tara L. Costich, Anthony Magliocco, Douglas Marchion, Richard Klar, Sven Michel, Frank Jaschinski, Richard R. Reich, Shikhar Mehrotra, Juan R. Cubillos-Ruiz, David H. Munn, Jose R. Conejo-Garcia, Paulo C. Rodriguez
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
T-cell function impairment is one of the major determinants of tumour immune evasion. Here, the authors show that the hostile conditions in the tumour microenvironment lead to C/EBP homologous-protein upregulation in T cells via ER stress, resulting
Externí odkaz:
https://doaj.org/article/f05c7d9780cc4100b5638fc324c1bb21
Autor:
David Gonzalez-Perez, Satyajit Das, Daniel Antfolk, Hadia S. Ahsan, Elliot Medina, Carolyn E. Dundes, Rayyan T. Jokhai, Emily D. Egan, Stephen C. Blacklow, Kyle M. Loh, Paulo C. Rodriguez, Vincent C. Luca
Publikováno v:
Nature Chemical Biology. 19:9-17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::283c38fb80538161d1d835995b238ede
https://doi.org/10.1038/s41589-022-01113-4
https://doi.org/10.1038/s41589-022-01113-4
Autor:
Jim, Aasha I. Hoogland, Brent J. Small, Laura B. Oswald, Crystal Bryant, Yvelise Rodriguez, Brian D. Gonzalez, Xiaoyin Li, Michelle C. Janelsins, Hailey W. Bulls, Brian W. James, Bianca Arboleda, Claudia Colon-Echevarria, Mary K. Townsend, Shelley S. Tworoger, Paulo C. Rodriguez, Julienne E. Bower, Sachin M. Apte, Robert M. Wenham, Heather S. L.
Publikováno v:
Cancers; Volume 15; Issue 13; Pages: 3407
Previous research suggests that inflammation triggers cancer-treatment-related symptoms (i.e., fatigue, depression, and disruptions in sleep and physical activity), but evidence is mixed. This study examined relationships between inflammatory biomark
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::bfed7b5418b116285baf733304289caa
Autor:
Rebecca S. Hesterberg, Min Liu, Aya G. Elmarsafawi, John M. Koomen, Eric A. Welsh, Stephen G. Hesterberg, Sujeewa Ranatunga, Chunying Yang, Weimin Li, Harshani R. Lawrence, Paulo C. Rodriguez, Anders E. Berglund, John L. Cleveland
Publikováno v:
Cancer Immunology Research. 10:1263-1279
Chronic T-cell receptor (TCR) signaling in the tumor microenvironment is known to promote T-cell dysfunction. However, we reasoned that poorly immunogenic tumors may also compromise T cells by impairing their metabolism. To address this, we assessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7c83fd67d57fc72eeddf16a4647174
https://doi.org/10.1158/2326-6066.cir-21-0813
https://doi.org/10.1158/2326-6066.cir-21-0813