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pro vyhledávání: '"Paulo Avalle"'
Autor:
Sarah E. Brewer, Ed Cleator, Debra J. Wallace, Paulo Avalle, Jeremy P. Scott, Andrew D. Gibb, Faye J. Sheen, Matthew M. Bio, Antony J. Davies, Gavin W. Stewart, Robert D. Wilson
Publikováno v:
Organic Process Research & Development. 17:1561-1567
The process development and multikilogram preparation of a TRPV1 antagonist, 1, is described. Pyrido[2,3-b]pyrazine 1 was prepared in a convergent manner by the coupling of two key fragments, glyoxal 2 and diamine 3. Glyoxal 2 was synthesized in six
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a55245a654caf02dc06470afc8eea876
https://doi.org/10.1021/op400304h
https://doi.org/10.1021/op400304h
