Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Paulius Grigaravicius"'
Autor:
Tatiana Kamaletdinova, Wen Zong, Pavel Urbánek, Sijia Wang, Mara Sannai, Paulius Grigaravičius, Wenli Sun, Zahra Fanaei-Kahrani, Aswin Mangerich, Michael O. Hottiger, Tangliang Li, Zhao-Qi Wang
Publikováno v:
Cells, Vol 12, Iss 16, p 2078 (2023)
Poly(ADP-ribose) polymerase-1 (PARP1) binds DNA lesions to catalyse poly(ADP-ribosyl)ation (PARylation) using NAD+ as a substrate. PARP1 plays multiple roles in cellular activities, including DNA repair, transcription, cell death, and chromatin remod
Externí odkaz:
https://doaj.org/article/c8b21dae7a244deb88485f743c0cbda5
Autor:
Shalmali Shukla, Ronny Haenold, Pavel Urbánek, Lucien Frappart, Shamci Monajembashi, Paulius Grigaravicius, Sigrun Nagel, Woo Kee Min, Alicia Tapias, Olivier Kassel, Heike Heuer, Zhao-Qi Wang, Aspasia Ploubidou, Peter Herrlich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Cilia, tiny outgrowths of cells, are essential for life. Here, the author’s describe the scaffold protein TRIP6, which promotes the assembly of ciliary proteins required for ciliogenesis, and show that its absence results in hydrocephalus.
Externí odkaz:
https://doaj.org/article/4652349346cd445aaa9dd98d42752636
Autor:
Murat Kirtay, Josefine Sell, Christian Marx, Holger Haselmann, Mihai Ceanga, Zhong-Wei Zhou, Vahid Rahmati, Joanna Kirkpatrick, Katrin Buder, Paulius Grigaravicius, Alessandro Ori, Christian Geis, Zhao-Qi Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Ataxia Telangiectasia and Rad3-related (ATR) is a key regulator of replication stress response; yet, mutations within the ATR gene cause human ATR-Seckel Syndrome associated with microcephaly and intellectual disability. Here, the authors show neuron
Externí odkaz:
https://doaj.org/article/2dd9c267ac854fe5bdc2ba175941b03b
Autor:
Alicia Tapias, David Lázaro, Bo-Kun Yin, Seyed Mohammad Mahdi Rasa, Anna Krepelova, Erika Kelmer Sacramento, Paulius Grigaravicius, Philipp Koch, Joanna Kirkpatrick, Alessandro Ori, Francesco Neri, Zhao-Qi Wang
Publikováno v:
eLife, Vol 10 (2021)
Brain homeostasis is regulated by the viability and functionality of neurons. HAT (histone acetyltransferase) and HDAC (histone deacetylase) inhibitors have been applied to treat neurological deficits in humans; yet, the epigenetic regulation in neur
Externí odkaz:
https://doaj.org/article/33e304c7257749b2a06dea0c9d2f2260
Autor:
Gabriel E. Matos-Rodrigues, Pedro B. Tan, Maurício Rocha-Martins, Clara F. Charlier, Anielle L. Gomes, Felipe Cabral-Miranda, Paulius Grigaravicius, Thomas G. Hofmann, Pierre-Olivier Frappart, Rodrigo A. P. Martins
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 10 (2020)
Seckel syndrome is a type of microcephalic primordial dwarfism (MPD) that is characterized by growth retardation and neurodevelopmental defects, including reports of retinopathy. Mutations in key mediators of the replication stress response, the mutu
Externí odkaz:
https://doaj.org/article/bb33c090dc6e4230a90edb6589fa1b1b
Autor:
Gabriel E. Matos-Rodrigues, Paulius Grigaravicius, Bernard S. Lopez, Thomas G. Hofmann, Pierre-Olivier Frappart, Rodrigo A. P. Martins
Publikováno v:
Cell Death and Disease, Vol 11, Iss 12, Pp 1-1 (2020)
A Correction to this paper has been published: https://doi.org/10.1038/s41419-020-03227-w
Externí odkaz:
https://doaj.org/article/e3f5f4ceb9c449a59cd5b061bacf93cc
Autor:
Paulo M. G. Rodrigues, Paulius Grigaravicius, Martina Remus, Gabriel R. Cavalheiro, Anielle L. Gomes, Maurício Rocha-Martins, Lucien Frappart, David Reuss, Peter J. McKinnon, Andreas von Deimling, Rodrigo A. P. Martins, Pierre-Olivier Frappart
Publikováno v:
PLoS ONE, Vol 8, Iss 8 (2013)
Externí odkaz:
https://doaj.org/article/d4d6856a2ea942ffaf0a211991b3dec6
Autor:
Paulo M G Rodrigues, Paulius Grigaravicius, Martina Remus, Gabriel R Cavalheiro, Anielle L Gomes, Maurício Rocha-Martins, Lucien Frappart, David Reuss, Peter J McKinnon, Andreas von Deimling, Rodrigo A P Martins, Pierre-Olivier Frappart
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69209 (2013)
Nibrin (NBN or NBS1) and ATM are key factors for DNA Double Strand Break (DSB) signaling and repair. Mutations in NBN or ATM result in Nijmegen Breakage Syndrome and Ataxia telangiectasia. These syndromes share common features such as radiosensitivit
Externí odkaz:
https://doaj.org/article/1f7dacd6af75412a94f5205780fff290
Autor:
Zhao-Qi Wang, Holger Haselmann, Vahid Rahmati, Paulius Grigaravicius, Joanna Kirkpatrick, Mihai Ceanga, Christian Geis, Zhong-Wei Zhou, Murat Kirtay, Katrin Buder, Josefine Sell, Christian Marx, Alessandro Ori
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications
Nature Communications
Ataxia Telangiectasia and Rad3-related (ATR) protein, as a key DNA damage response (DDR) regulator, plays an essential function in response to replication stress and controls cell viability. Hypomorphic mutations of ATR cause the human ATR-Seckel syn
Autor:
Shamci Monajembashi, Alicia Tapias, Ronny Haenold, Heike Heuer, Zhao-Qi Wang, Sigrun Nagel, Wookee Min, Pavel Urbanek, Paulius Grigaravicius, Olivier Kassel, Lucien Frappart, Shalmali Shukla, Peter A Herrlich, Aspasia Ploubidou
Publikováno v:
Nature Communications
Nature Communications, 12 (1), Art.-Nr.: 5887
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications, 12 (1), Art.-Nr.: 5887
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
TRIP6, a member of the ZYXIN-family of LIM domain proteins, is a focal adhesion component. Trip6 deletion in the mouse, reported here, reveals a function in the brain: ependymal and choroid plexus epithelial cells are carrying, unexpectedly, fewer an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28dfed021559fccf8cb965ce9e67a30a