Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis

Autor: Melissa Schepers, Dean Paes, Assia Tiane, Ben Rombaut, Elisabeth Piccart, Lieve van Veggel, Pascal Gervois, Esther Wolfs, Ivo Lambrichts, Chiara Brullo, Olga Bruno, Ernesto Fedele, Roberta Ricciarelli, Charles ffrench-Constant, Marie E. Bechler, Pauline van Schaik, Wia Baron, Evy Lefevere, Kobi Wasner, Anne Grünewald, Catherine Verfaillie, Paulien Baeten, Bieke Broux, Paul Wieringa, Niels Hellings, Jos Prickaerts, Tim Vanmierlo

Publikováno v: Brain Behavior and Immunity, 109, 1-22. Elsevier Science

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) characterized by focal inflammatory lesions and prominent demyelination. Even though the currently available therapies are effective in treating the initial s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b770c84050d1fd6b3d56d5c62397da38
http://orbilu.uni.lu/handle/10993/53476

Inflammation and mitochondrial dysfunction

Autor: Maarten E. Witte, Jack van Horssen, Pauline van Schaik

Publikováno v: Neuroscience Letters, 710:132931. Elsevier Ireland Ltd
van Horssen, J, van Schaik, P & Witte, M 2019, ' Inflammation and mitochondrial dysfunction : A vicious circle in neurodegenerative disorders? ', Neuroscience Letters, vol. 710, 132931 . https://doi.org/10.1016/j.neulet.2017.06.050

Experimental evidence supports an intricate association between inflammation and mitochondrial dysfunction as main contributors of neurological diseases. Inflammatory mediators produced by activated microglia and infiltrated immune cells trigger intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11dc4baab575355a8ae54ba627d82a95
https://doi.org/10.1016/j.neulet.2017.06.050