Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Pauline Thémans"'
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Akademický článek
Towards a Generic Tool for Prediction of Meropenem Systemic and Infection-Site Exposure: A Physiologically Based Pharmacokinetic Model for Adult Patients with Pneumonia
Autor: Pauline Thémans, Pierre Marquet, Joseph J. Winkin, Flora T. Musuamba
Publikováno v: Drugs in R&D, Vol 19, Iss 2, Pp 177-189 (2019)
Abstract Objective The objective of this study was to develop a physiologically based pharmacokinetic model for meropenem using a retrograde approach, which could serve as a basis for prediction of the systemic and infection-site drug exposures in di
Externí odkaz: https://doaj.org/article/58de055663a7459c92aa65be6b37701c
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2
Population Pharmacokinetics of Hydroxychloroquine in COVID-19 Patients: Implications for Dose Optimization
Autor: Leila Belkhir, Kevin-Alexandre Delongie, Pierre Wallemacq, Veerle Verlinden, Xavier Wittebole, Cecile Lescrainier, Jamila Hamdani, Flora T. Musuamba, Rakan Nasreddine, Martin Vandeputte, Pauline Thémans, Francoise Wuillaume, Julien De Greef, Jean-Michel Dogné, Nicolas Dauby, Jean-Cyr Yombi, Sophie Kiridis
Publikováno v: European Journal of Drug Metabolism and Pharmacokinetics
Thémans, P, Belkhir, L, Dauby, N, Yombi, J C, De Greef, J, Delongie, K A, Vandeputte, M, Nasreddine, R, Wittebole, X, Wuillaume, F, Lescrainier, C, Verlinden, V, Kiridis, S, Dogné, J M, Hamdani, J, Wallemacq, P & Musuamba Tshinanu, F 2020, ' Population Pharmacokinetics of Hydroxychloroquine in COVID-19 Patients : Implications for Dose Optimization ', European Journal of Drug Metabolism and Pharmacokinetics, vol. 45, no. 6, pp. 703-713 . https://doi.org/10.1007/s13318-020-00648-y
European journal of drug metabolism and pharmacokinetics, Vol. 45, no.6, p. 703-713 (2020)
European journal of drug metabolism and pharmacokinetics, 45 (6
Background and Objective: In the absence of characterization on pharmacokinetics and reference concentrations for hydroxychloroquine in COVID-19 patients, the dose and treatment duration for hydrochloroquine are currently empirical, mainly based on i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3204e0996e3ebcf3d92d43467f2b3ef1
http://europepmc.org/articles/PMC7511144
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3
Model-based Strategies of Drug Dosing for Pharmacokinetic Systems
Autor: Flora T. Musuamba, Pauline Thémans, Joseph J. Winkin
Publikováno v: THEMANS, PAULINE, Musuamba Tshinanu, F & WINKIN, J 2021, ' Model-based Strategies of Drug Dosing for Pharmacokinetic Systems ', IFAC-PapersOnLine, vol. 53, no. 2, pp. 16061-16068 . https://doi.org/10.1016/j.ifacol.2020.12.421
The aim of this paper is to report analytical and individual-based methods forantibiotic dose selection, that are based on tools from system and control theory. A brief system analysis of standard population pharmacokinetic models proves that such mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4a753e8047f722e562e321d998eeb2
https://doi.org/10.1016/j.ifacol.2020.12.421
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5
Input-output approaches for personalized drug dosing of antibiotics
Autor: Pauline Thémans, Flora Tshinanu Musuamba, Joseph J. Winkin
The aim of this chapter is to report analytical and individual-based methods for antibiotic dose selection that are based on tools from system and control theory. A brief system analysis of standard population pharmacokinetic models proves that such
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8bdd14fc1b2b3be75ee494d804ce30
https://doi.org/10.1016/b978-0-32-390171-0.00012-3
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6
Towards a Generic Tool for Prediction of Meropenem Systemic and Infection-Site Exposure: A Physiologically Based Pharmacokinetic Model for Adult Patients with Pneumonia
Autor: Pierre Marquet, Pauline Thémans, Joseph J. Winkin, Flora T. Musuamba
Publikováno v: Drugs in R&D
Drugs in R&D, Vol 19, Iss 2, Pp 177-189 (2019)
Objective The objective of this study was to develop a physiologically based pharmacokinetic model for meropenem using a retrograde approach, which could serve as a basis for prediction of the systemic and infection-site drug exposures in different p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5d2a28645927b3668b208eafb5bd6c
https://doi.org/10.1007/s40268-019-0268-x
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7
Model informed dosing of hydroxycholoroquine in COVID-19 patients: Learnings from the recent experience, remaining uncertainties and gaps
Autor: Deborah Konopnicki, Veerle Verlinden, Francoise Wuillaume, Cecile Lescrainier, Rakan Nasreddine, Marie-Christine Payen, Pauline Thémans, Nicolas Dauby, Jamila Hamdani, Faustine Lebout, Flora T. Musuamba, Jean-Michel Dogné, Marc Delforge, Agnès Libois, Loïc Schrooyen
Publikováno v: British journal of clinical pharmacology
British Journal of Clinical Pharmacology
Thémans, P, Dauby, N, Schrooyen, L, Lebout, F, Delforge, M, Nasreddine, R, Libois, A, Payen, M C, Konopnicki, D, Wuillaume, F, Lescrainier, C, Verlinden, V, Dogné, J M, Hamdani, J & Musuamba Tshinanu, F 2021, ' Model informed dosing of hydroxycholoroquine in COVID-19 patients : Learnings from the recent experience, remaining uncertainties and gaps ', British Journal of Clinical Pharmacology, vol. 87, no. 2, pp. 674-682 . https://doi.org/10.1111/bcp.14436
Aims: In the absence of a commonly agreed dosing protocol based on pharmacokinetic (PK) considerations, the dose and treatment duration for hydroxychloroquine (HCQ) in COVID-19 disease currently vary across national guidelines and clinical study prot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9244520dd821326257e798a57a479584
https://pubmed.ncbi.nlm.nih.gov/32559820
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8
Optimal wavelength for the clot waveform analysis: Determination of the best resolution with minimal interference of the reagents
Autor: Julie Laloy, Jonathan Douxfils, Jonathan Evrard, Jean-Michel Dogné, Pauline Thémans, Laure Morimont, Céline Bouvy, Damien Gheldof, François Mullier, Romain Siriez
Publikováno v: International journal of laboratory hematology, Vol. 41, no. 3, p. 316-324 (2019)
Introduction: Clot waveform analysis (CWA), a new methodology to assess coagulation process, can be usefully applied in various clinical settings. However, its clinical use is limited mainly because of the absence of standardization. No consensus exi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1fa8d45ada87c32f3ad5b9a116138c
https://pubmed.ncbi.nlm.nih.gov/30730600
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