Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Pauline T. Lukey"'
Autor:
Alison E. John, Rebecca H. Graves, K. Tao Pun, Giovanni Vitulli, Ellen J. Forty, Paul F. Mercer, Josie L. Morrell, John W. Barrett, Rebecca F. Rogers, Maryam Hafeji, Lloyd I. Bibby, Elaine Gower, Valerie S. Morrison, Yim Man, James A. Roper, Jeni C. Luckett, Lee A. Borthwick, Ben S. Barksby, Rachel A. Burgoyne, Rory Barnes, Joelle Le, David J. Flint, Susan Pyne, Anthony Habgood, Louise A. Organ, Chitra Joseph, Rochelle C. Edwards-Pritchard, Toby M. Maher, Andrew J. Fisher, Natasja Stæhr Gudmann, Diana J. Leeming, Rachel C. Chambers, Pauline T. Lukey, Richard P. Marshall, Simon J. F. Macdonald, R. Gisli Jenkins, Robert J. Slack
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The αvβ6 integrin is key in activating the pro-fibrotic cytokine TGFβ in idiopathic pulmonary fibrosis. Here, the authors show an inhaled small molecule αvβ6 inhibitor GSK3008348 induces prolonged inhibition of TGFβ signaling pathways in human
Externí odkaz:
https://doaj.org/article/0b6e5916f4cb4d2e9b4186f07f1b86ee
Autor:
Toby M. Maher, Juliet K. Simpson, Joanna C. Porter, Frederick J. Wilson, Robert Chan, Rhena Eames, Yi Cui, Sarah Siederer, Simon Parry, Julia Kenny, Robert J. Slack, Jagdeep Sahota, Lyn Paul, Peter Saunders, Philip L. Molyneaux, Pauline T. Lukey, Gaia Rizzo, Graham E. Searle, Richard P. Marshall, Azeem Saleem, Arthur R. Kang’ombe, David Fairman, William A. Fahy, Mitra Vahdati-Bolouri
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with poor prognosis and a significant unmet medical need. This study evaluated the safety, pharmacokinetics (PK) and target engagement in the lungs, of GSK
Externí odkaz:
https://doaj.org/article/b310527f153e4b93b1313adc1b6024f2
Autor:
Omar S. Usmani, Martyn F. Biddiscombe, Shuying Yang, Sally Meah, Eunice Oballa, Juliet K. Simpson, William A. Fahy, Richard P. Marshall, Pauline T. Lukey, Toby M. Maher
Publikováno v:
Respiratory Research, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Our aim was to investigate total and regional lung delivery of salbutamol in subjects with idiopathic pulmonary fibrosis (IPF). Methods The TOPICAL study was a 4-period, partially-randomised, controlled, crossover study to investi
Externí odkaz:
https://doaj.org/article/976cf63d29d3478184502849fb899aef
Autor:
Joanna C Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny, Rebecca Evans, Mia I Temkin, Nathalia De Vasconcelos, Iker Valle Aramburu, Dennis Hoving, Donna Basire, Tracey Crissell, Jesusa Guinto, Alison Webb, Hanif Esmail, Victoria Johnston, Anna Last, Thomas Rampling, Lena Lippert, Elisa Theresa Helbig, Florian Kurth, Bryan Williams, Aiden Flynn, Pauline T Lukey, Veronique Birault, Venizelos Papayannopoulos
Publikováno v:
eLife, Vol 12 (2024)
Background: Prinflammatory extracellular chromatin from neutrophil extracellular traps (NETs) and other cellular sources is found in COVID-19 patients and may promote pathology. We determined whether pulmonary administration of the endonuclease dorna
Externí odkaz:
https://doaj.org/article/aa0642bdfc68412890699c84f062b563
Autor:
Joanna C. Porter, Jamie Inshaw, Vincente Joel Solis, Emma Denneny, Rebecca Evans, Mia I. Temkin, Nathalia De Vasconcelos, Iker Valle Aramburu, Dennis Hoving, Donna Basire, Tracey Crissell, Jesusa Guinto, Alison Webb, Hanif Esmail, Victoria Johnston, Anna Last, Thomas Rampling, Bryan Williams, Aiden Flynn, Pauline T Lukey, Veronique Birault, Venizelos Papayannopoulos
BackgroundSARS-CoV2 infection causes severe, life-threatening pneumonia. Hyper-inflammation, coagulopathy and lymphopenia are associated with pathology and poor outcomes in these patients. Cell-free (cf) DNA is prominent in COVID-19 patients, amplifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86dfe7d4ab8b1c52fd3a97d5be18ddbe
https://doi.org/10.1101/2022.04.14.22272888
https://doi.org/10.1101/2022.04.14.22272888
Autor:
Natasja Stæhr Gudmann, Richard P. Marshall, Jeni Luckett, Rebecca F. Rogers, Robert J. Slack, Simon J. F. Macdonald, Diana Julie Leeming, Rachel C. Chambers, Joelle Le, Pauline T. Lukey, Anthony Habgood, Paul F. Mercer, Rachel A. Burgoyne, Ben S. Barksby, Lloyd I. Bibby, Yim Man, Maryam Hafeji, Andrew J. Fisher, David J. Flint, Toby M. Maher, Louise Organ, Susan Pyne, Lee A. Borthwick, James A. Roper, Valerie S. Morrison, Alison E. John, Giovanni Vitulli, Rebecca H. Graves, Rochelle C. Edwards-Pritchard, R. Gisli Jenkins, John Barrett, Josie Morrell, K. Tao Pun, Elaine Gower, Rory Barnes, Ellen J. Forty, Chitra Joseph
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The αvβ6 integrin plays a key role in the activation of transforming growth factor-β (TGFβ), a pro-fibrotic mediator that is pivotal to the development of idiopathic pulmonary fibrosis (IPF). We identified a selective small molecule αvβ6 RGD-mi
Autor:
Christophe Plisson, Lisa Wells, Christine A. Parker, Mayca Onega, Sara Moz, Nicholas Keat, Christopher Coello, Pauline T. Lukey, Giovanni Vitulli, Joaquim Ramada-Magalhaes, Roger N. Gunn, Frederick J. Wilson, Sharon Ashworth, Robert J. Slack, Sac-Pham Tang, Gaia Rizzo, Jan Passchier
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
PurposeIntegrin αvβ6belongs to the RGD subset of the integrin family, and its expression levels are a prognostic and theranostic factor in some types of cancer and pulmonary fibrosis. This paper describes the GMP radiolabelling of the synthetic 20
Autor:
Toby M. Maher, Arthur R. Kang’ombe, Allan Listanco, Azeem Saleem, Richard P. Marshall, Joaquim Ramada-Magalhaes, Gisli Jenkins, Maria Costa, Christopher Coello, Pauline T. Lukey, James Davies, Sara Moz, Stuart Kendrick, Roger N. Gunn, Nadia Garman, Christine A. Parker, William A. Fahy, Mayca Onega, Jan Passchier, Frederick J. Wilson
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
PurposeThe RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation of transforming growth factor beta (TGFβ). This study sought to quantify expression of αvβ6 in the lungs of healthy humans and subjects with
Autor:
Jagdeep Sahota, David Fairman, Peter Saunders, Richard P. Marshall, William A. Fahy, Philip L. Molyneaux, Azeem Saleem, Lyn Paul, Gaia Rizzo, Yi Cui, Graham E. Searle, Frederick J. Wilson, Juliet Kay Simpson, Julia Kenny, Arthur R. Kang’ombe, Mitra Vahdati-Bolouri, Sarah Siederer, Joanna C. Porter, Robert Chan, Pauline T. Lukey, Toby M. Maher, Robert J. Slack, Simon Parry, Rhena Eames
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020)
Respiratory Research
Respiratory Research
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disease with poor prognosis and a significant unmet medical need. This study evaluated the safety, pharmacokinetics (PK) and target engagement in the lungs, of GSK3008348,