Výsledky vyhledávání - "Pauline T Velasco"

Akademický článek

Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers.

Autor: Kyle C Wilcox, Matthew R Marunde, Aditi Das, Pauline T Velasco, Benjamin D Kuhns, Michael T Marty, Haoming Jiang, Chi-Hao Luan, Stephen G Sligar, William L Klein

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0125263 (2015)

Despite their value as sources of therapeutic drug targets, membrane proteomes are largely inaccessible to high-throughput screening (HTS) tools designed for soluble proteins. An important example comprises the membrane proteins that bind amyloid β

Externí odkaz: https://doaj.org/article/09975a8c58e848ea9ad0aaa832ef9023

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Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease

Autor: Pauline T. Velasco, Vinayak P. Dravid, William L. Klein, Kirsten L. Viola, Jane Wang, James Sbarboro, Ruchi Sureka, Chang Lu, Joseph C. Phan, Hrushikesh M. Joshi, Mrinmoy De, Shaleen Vasavada, Pottumarthi V. Prasad, Pascale N. Lacor, Keith W. MacRenaris, E. Alex Waters, Summer Wu, Sreyesh Satpathy, Maira A. Bicca

Publikováno v: Nature nanotechnology

One way to image the molecular pathology in Alzheimer's disease is by positron emission tomography using probes that target amyloid fibrils. However, these fibrils are not closely linked to the development of the disease. It is now thought that early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f273c69c8cd9fd9a1c66dfbf583491
https://doi.org/10.1038/nnano.2014.254

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A human scFv antibody that targets and neutralizes high molecular weight pathogenic amyloid-β oligomers

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Brain accumulation of soluble oligomers of the amyloid-β peptide (AβOs) is increasingly considered a key early event in the pathogenesis of Alzheimer's disease (AD). A variety of AβO species have been identified, both in vitro and in vivo, ranging

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e9b91f182753f7597bc2544d7ce536
https://pubmed.ncbi.nlm.nih.gov/28670737

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Brain Transit and Ameliorative Effects of Intranasally Delivered Anti-Amyloid-β Oligomer Antibody in 5XFAD Mice

Autor: Kirsten L. Viola, Pascale N. Lacor, Chun Xiao, Balwantsinh C. Chauhan, Pauline T. Velasco, William L. Klein, Neelima B. Chauhan, Francesca Davis

Publikováno v: Journal of Alzheimer's Disease. 35:777-788

Alzheimer’s disease (AD) is a global health crisis with limited treatment options. Despite major advances in neurotherapeutics, poor brain penetration due to the blood-brain barrier continues to pose a big challenge in overcoming the access of ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead3fefc7dc5c91365d3e7592c30c10b
https://doi.org/10.3233/jad-122419

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Deleterious Effects of Amyloid β Oligomers Acting as an Extracellular Scaffold for mGluR5

Autor: Anis Contractor, Pauline T. Velasco, Jian Xu, William L. Klein, Antoine Triller, Marianne Renner, Pascale N. Lacor

Publikováno v: Neuron. 66(5):739-754

Soluble oligomers of amyloid beta (Abeta) play a role in the memory impairment characteristic of Alzheimer's disease. Acting as pathogenic ligands, Abeta oligomers bind to particular synapses and perturb their function, morphology, and maintenance. E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eeb17cf70218fbf3a5f4da7e620f4bb

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Alzheimer's-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal

Autor: Pauline T. Velasco, William L. Klein, Matthew R. Blankenship, William Roth, Fernanda G. De Felice, Jason Pitt, Paul A. S. Breslin, Amos B. Smith, Pascale N. Lacor

Publikováno v: Toxicology and Applied Pharmacology. 240:189-197

It now appears likely that soluble oligomers of amyloid-beta1-42 peptide, rather than insoluble fibrils, act as the primary neurotoxin in Alzheimer's disease (AD). Consequently, compounds capable of altering the assembly state of these oligomers (ref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc4ca044848a19a4db5e366dd402812
https://doi.org/10.1016/j.taap.2009.07.018

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Targeting Generation of Antibodies Specific to Conformational Epitopes of Amyloid β-Derived Neurotoxins

Autor: William L. Klein, Kirsten L. Viola, Mary P. Lambert, Pauline T. Velasco

Publikováno v: CNS & Neurological Disorders - Drug Targets. 8:65-81

Individuals with early Alzheimers disease (AD) suffer from a selective and profound failure to form new memories. A novel molecular mechanism with implications for therapeutics and diagnostics is now emerging in which the specificity of AD for memory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8eb0677db4d31f255dcd3106d313146
https://doi.org/10.2174/187152709787601876

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Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

Autor: Kirsten L. Viola, Mary P. Lambert, Pauline T. Velasco, Wei Qin Zhao, Fernanda G. De Felice, Helena Decker, Theresa R. Bomfim, Marcelo N. N. Vieira, William L. Klein, Sergio T. Ferreira

Publikováno v: Proceedings of the National Academy of Sciences. 106:1971-1976

Synapse deterioration underlying severe memory loss in early Alzheimer's disease (AD) is thought to be caused by soluble amyloid beta (Aβ) oligomers. Mechanistically, soluble Aβ oligomers, also referred to as Aβ-derived diffusible ligands (ADDLs),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c6f9a3d31cca4424186b5605071d38c
https://doi.org/10.1073/pnas.0809158106

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Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Aβ oligomers

Autor: Paul Acton, Sara J. Fernandez, Gene G. Kinney, Diana Wu, William L. Klein, Mary P. Lambert, Elizabeth Chen-Dodson, Paul J. Shughrue, Eileen H. Bigio, Jasna Jerecic, Fernanda G. De Felice, Pauline T. Velasco, Pascale N. Lacor

Publikováno v: Neurobiology of Aging. 29:1334-1347

Alzheimer's disease (AD) is characterized by presence of extracellular fibrillar A beta in amyloid plaques, intraneuronal neurofibrillary tangles consisting of aggregated hyperphosphorylated tau and elevated brain levels of soluble A beta oligomers (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5d6b5988196b1df5a56d0a3bc164aa
https://doi.org/10.1016/j.neurobiolaging.2007.02.029

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Why Alzheimer’s is a disease of memory: The attack on synapses by Aß oligomers (ADDLs)

Autor: Kirsten L. Viola, Pauline T. Velasco, William L. Klein

Publikováno v: The Journal of Nutrition Health and Aging. 12:S51-S57

Individuals with early-stage Alzheimer's disease (AD) suffer from profound failure to form new memories. A novel molecular mechanism with implications for therapeutics and diagnostics is now emerging in which the specificity of AD for memory derives

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc5a80c00dca07133826a045965bb95
https://doi.org/10.1007/bf02982587

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