Blockade of IL-33R/ST2 Signaling Attenuates Toxoplasma gondii Ileitis Depending on IL-22 Expression

Autor: Bernhard Ryffel, Feng Huang, Pauline Robinet, Corine Panek, Isabelle Couillin, François Erard, Julie Piotet, Marc Le Bert, Claire Mackowiak, Marbel Torres Arias, Isabelle Dimier-Poisson, Song Guo Zheng

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Oral T. gondii infection (30 cysts of 76K strain) induces acute lethal ileitis in sensitive C57BL/6 (B6) mice with increased expression of IL-33 and its receptor ST2 in the ileum. Here we show that IL-33 is involved in ileitis, since absence of IL-33

Externí odkaz: https://doaj.org/article/184e6954a1c74591a971e129b059e200

A polysaccharide virulence factor of a human fungal pathogen induces neutrophil apoptosis via NK cells

Autor: Florence Baychelier, Pauline Robinet, Vincent Vieillard, Capucine Picard, Carole Elbim, Thierry Fontaine, Jean-Paul Latgé, Patrice Debré

Publikováno v: Journal of Immunology
Journal of Immunology, 2014, 192 (11), pp.5332-5342. ⟨10.4049/jimmunol.1303180⟩
ResearcherID
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2014, 192 (11), pp.5332-5342. ⟨10.4049/jimmunol.1303180⟩

Aspergillus fumigatus is an opportunistic human fungal pathogen that sheds galactosaminogalactan (GG) into the environment. Polymorphonuclear neutrophils (PMNs) and NK cells are both part of the first line of defense against pathogens. We recently re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320c2ba623050c56492525257a8f9a8d
https://hal-pasteur.archives-ouvertes.fr/pasteur-01724671

Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells

Autor: Stéphane Charpentier, Lucile Mollet, Fabienne Brulé, Thierry Normand, Axel Aurouet, Alain Legrand, Martine Dubois, Francine Garnache-Ottou, Adelin Sureau, Eric Deconinck, Pierre Rohrlich, Camille Grandclement, Pauline Robinet

Publikováno v: Molecular Immunology
Molecular Immunology, 2013, 56 (1-2), pp.123-8. ⟨10.1016/j.molimm.2013.04.012⟩
Molecular Immunology, Elsevier, 2013, 56 (1-2), pp.123-8. ⟨10.1016/j.molimm.2013.04.012⟩

International audience; GALIG gene expression induces apoptosis in cultured cells through a pathway still under investigation. It is highly expressed in leukocytes but weakly detectable in bone marrow, suggesting a role in the myeloid lineage homeost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feff909f286d90d805d579b08b7907a6
https://hal.science/hal-00840170

The mitogaligin protein is addressed to the nucleus via a non-classical localization signal

Autor: Fabienne Brulé, Stéphane Charpentier, Lucile Mollet, Thierry Normand, Martine Dubois, Alain Legrand, Patrick Gonzalez, Pauline Robinet

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2010, 392 (1), pp.53-57. ⟨10.1016/j.bbrc.2009.12.162⟩

International audience; Mitogaligin, a protein encoded by galig, an internal cytotoxic gene of the galectin-3 locus, is mostly a mitochondrial protein. Mitochondrial targeting is due to an already identified mitochondrial localization signal. Interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cbe28f2e632d036900ebdb8301e654
https://pubmed.ncbi.nlm.nih.gov/20056110