Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Pauline R.M. Dobson"'
Publikováno v:
Asian Pacific Journal of Cancer Prevention : APJCP
Background Downregulation of AMPK has been established as a major contributor to carcinogenesis in many types of human cancer. We sought to investigate the influence of activated AMPK on apoptotic markers in human breast cancer cells differing in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a10aae61c889f9989df7b157a8ad7f
http://europepmc.org/articles/PMC7173391
http://europepmc.org/articles/PMC7173391
Autor:
Pauline R.M. Dobson, Imtiaz Ahmad Qureshi, Lila Damnhory, Jaudah Al-Maghrabi, Basim Al-Maghrabi, Kaltoom Al-Sakkaf, Mohamed F. Elshal, Barry L. Brown, Mohamad Nidal Khabaz, Sawsan Ashoor, Alia M. Aldahlawi, Nadeem Shafique Butt
Publikováno v:
Annals of Diagnostic Pathology. 29:62-67
Many investigators have examined the functions of AMP-activated protein kinase (AMPK) in cancer biology and its anti-neoplastic features in cancer models. The goal of this research is to assess the association of the immunohistochemical expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ce6410d94c2cc50a5279d7ea606e1d
https://doi.org/10.1016/j.anndiagpath.2017.05.012
https://doi.org/10.1016/j.anndiagpath.2017.05.012
Publikováno v:
Oncology Reports
AMP-activated protein kinase (AMPK), a sensor of cellular energy, is widely reported as a potential therapeutic target in treatment of breast and other cancers. The activated enzyme has been shown to be a promising anti-proliferative agent in breast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8a8498a69ef742255cf073bf2301663
https://doi.org/10.3892/or.2015.4198
https://doi.org/10.3892/or.2015.4198
Autor:
Jaudah Al-Maghrabi, Swsan Ashoor, Pauline R.M. Dobson, Alia M. Aldahlawi, Amer Shafie Abdelrahman, Basim Al-Maghrabi, Mohamad Nidal Khabaz, Barry L. Brown, Kaltoom Al-Sakkaf, Mohamed F. Elshal, Lila Damnhory, Mohmmad Al-Qahtani, Nadeem Shafique Butt
Publikováno v:
BMC Women's Health
BMC Women's Health, Vol 17, Iss 1, Pp 1-8 (2017)
BMC Women's Health, Vol 17, Iss 1, Pp 1-8 (2017)
Background Obesity is part of the established risk factors for breast cancer (BC) in postmenopausal females. Circulating leptin increases in parallel with the increase of body weight and fat reservoir. Methods This research investigated the link betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d913fbd050a45278fd90f0def8fc573a
http://europepmc.org/articles/PMC5680747
http://europepmc.org/articles/PMC5680747
Publikováno v:
Nitric Oxide. 9:123-134
Several murine and human monocytic cell lines and monocyte-derived macrophages (MDM) from healthy volunteers were studied to compare their production of nitric oxide (NO) and induction of iNOS following endotoxin treatment. Although the human cells w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e310969d1a46d148b74f7e9ee28e7f5
https://doi.org/10.1016/j.niox.2003.09.006
https://doi.org/10.1016/j.niox.2003.09.006
Autor:
Colby L. Eaton, Freddie C. Hamdy, A. Ruffion, Pauline R.M. Dobson, Barry L. Brown, K. A. Al-Sakkaf
Publikováno v:
European Urology. 43:301-308
Objectives: Recent studies suggest a paracrine/autocrine loop involving prolactin (PRL) within the human prostate. The aims of this study were to determine the effects of PRL on the growth and survival of prostate cancer cells and the intracellular s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c0eee1ffca53d5b979474e3aab0450
https://doi.org/10.1016/s0302-2838(03)00038-1
https://doi.org/10.1016/s0302-2838(03)00038-1
Publikováno v:
British Journal of Cancer
To investigate the mechanisms underlying apoptosis in breast cancer cells, staurosporine was used as an apoptotic stimulus in the human breast cancer cell lines MCF-7 and T47D. Staurosporine induced dose and time dependent increases in DNA fragmentat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7fbcd459b0a09becdb3d5579180924
https://doi.org/10.1038/sj.bjc.6600541
https://doi.org/10.1038/sj.bjc.6600541
Publikováno v:
Journal of Endocrinology. 167:85-92
Prolactin (PRL) is a mitogen for a number of cell types and its action as a survival factor has recently been demonstrated in Nb2 lymphoma cells. However, the intracellular signalling pathways by which PRL promotes the survival of Nb2 cells is unknow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeafb0d07386fedc0155f4e874e959ce
https://doi.org/10.1677/joe.0.1670085
https://doi.org/10.1677/joe.0.1670085
Publikováno v:
Journal of Molecular Endocrinology. 19:347-350
Our previous studies indicated that PI3-kinase is involved in prolactin (PRL) signalling. We have now examined the involvement of the src tyrosine kinase, fyn, in PRL-induced the activation of PI3-kinase in the rat lymphoma cell line, Nb2. Cells were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a9126b825e41327bbea9f3c2363236e
https://doi.org/10.1677/jme.0.0190347
https://doi.org/10.1677/jme.0.0190347
Publikováno v:
Cytokine. 9:577-581
NIH 3T3 cells express the alpha, delta, epsilon and zeta isoenzymes of protein kinase C(PKC). Following stimulation of cells (24 h) with the pro-inflammatory cytokine, interleukin 1beta (IL-1beta), we observed, by Western blotting, a dose-dependent e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec090e37796c26466884b8999188d421
https://doi.org/10.1006/cyto.1997.0204
https://doi.org/10.1006/cyto.1997.0204