Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Pauline N. C. B. Audergon"'
Autor:
Pauline N. C. B. Audergon, Alison L. Pidoux, Imtiyaz Yaseen, Manu Shukla, Sito Torres-Garcia, Robin C. Allshire, Sharon A. White
Publikováno v:
Torres-Garcia, S, Yaseen, I, Shukla, M, Audergon, P N C B, White, S, Pidoux, A & Allshire, R C 2020, ' Epigenetic gene silencing by heterochromatin primes fungal resistance ', Nature, vol. 585, pp. 453-458 . https://doi.org/10.1038/s41586-020-2706-x
Nature
Nature
Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders embedded genes transcriptionally silent1–3. In the fission yeast Schizosaccharomyces pombe, H3K9me heterochromatin can be transmitted through cell division provided th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d50d688dadb4308b0ca3e52ff9178a4
https://hdl.handle.net/20.500.11820/2e5ecc1a-63be-430c-b68a-b7d9e189a31b
https://hdl.handle.net/20.500.11820/2e5ecc1a-63be-430c-b68a-b7d9e189a31b
Autor:
Sharon A. White, Robin C. Allshire, Alison L. Pidoux, Sito Torres-Garcia, Pauline N. C. B. Audergon, Manu Shukla
SummaryGenes embedded in H3 lysine 9 methylation (H3K9me)–dependent heterochromatin are transcriptionally silenced1-3. In fission yeast,Schizosaccharomyces pombe, H3K9me heterochromatin silencing can be transmitted through cell division provided th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f36f9f9d13e69d2b441f318c7807e0e
A major goal for stem cell research and its clinical applications is to derive high quality human pluripotent stem cell (hPSC) lines that recapitulate in culture the properties of epiblast cells from human blastocyst embryos. Recent developments in d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a6a2a375acaebe7903417df94f9047
https://europepmc.org/articles/PMC5503910/
https://europepmc.org/articles/PMC5503910/
Autor:
Robin C. Allshire, Georgina L. Hamilton, Pauline N. C. B. Audergon, Alessia Buscaino, Erwan Lejeune, Alison L. Pidoux
Publikováno v:
The EMBO Journal
Buscaino, A, Lejeune, E, Audergon, P, Hamilton, G, Pidoux, A & Allshire, R C 2013, ' Distinct roles for Sir2 and RNAi in centromeric heterochromatin nucleation, spreading and maintenance ', EMBO Journal, vol. 32, no. 9, pp. 1250-1264 . https://doi.org/10.1038/emboj.2013.72
Buscaino, A, Lejeune, E, Audergon, P, Hamilton, G, Pidoux, A & Allshire, R C 2013, ' Distinct roles for Sir2 and RNAi in centromeric heterochromatin nucleation, spreading and maintenance ', EMBO Journal, vol. 32, no. 9, pp. 1250-1264 . https://doi.org/10.1038/emboj.2013.72
Epigenetically regulated heterochromatin domains govern essential cellular activities. A key feature of heterochromatin domains is the presence of hypoacetylated nucleosomes, which are methylated on lysine 9 of histone H3 (H3K9me). Here, we investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023795274370cdb99252b77d3468599f
https://doi.org/10.1038/emboj.2013.72
https://doi.org/10.1038/emboj.2013.72
Autor:
Jason C. Tanny, J. Peter Svensson, Pauline N. C. B. Audergon, Victoria Menendez-Benito, Indranil Sinha, Manu Shukla, Ulrika Norman-Axelsson, Robin C. Allshire, Karl Ekwall
Publikováno v:
Svensson, J P, Shukla, M, Menendez-Benito, V, Norman-Axelsson, U, Audergon, P, Sinha, I, Tanny, J C, Allshire, R C & Ekwall, K 2015, ' A nucleosome turnover map reveals that the stability of histone H4 Lys20 methylation depends on histone recycling in transcribed chromatin ', Genome Research, vol. 25, no. 6, pp. 872-883 . https://doi.org/10.1101/gr.188870.114
Nucleosome composition actively contributes to chromatin structure and accessibility. Cells have developed mechanisms to remove or recycle histones, generating a landscape of differentially aged nucleosomes. This study aimed to create a high-resoluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d1c49e3360e33ae74bceb6982a2776
https://europepmc.org/articles/PMC4448683/
https://europepmc.org/articles/PMC4448683/
Autor:
Pauline N. C. B. Audergon, Alexander Kagansky, Manu Shukla, Sandra Catania, Pin Tong, Robin C. Allshire, Alison L. Pidoux
Publikováno v:
Audergon, P N C B, Catania, S, Kagansky, A, Tong, P, Shukla, M, Pidoux, A L & Allshire, R C 2015, ' Restricted epigenetic inheritance of H3K9 methylation ', Science, vol. 348, no. 6230, pp. 132-135 . https://doi.org/10.1126/science.1260638
Inheritance of a covalent histone modification Genomic DNA is the repository of all genetic information and is packaged into chromatin. Chromatin is also a repository of regulatory information in the form of covalent marks added to the histones that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd43cdd756cd9d39f1c57d8f0268db87
https://europepmc.org/articles/PMC4397586/
https://europepmc.org/articles/PMC4397586/