Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Pauline Melenec"'
Autor:
Alessia Floerchinger, Kendelle J. Murphy, Sharissa L. Latham, Sean C. Warren, Andrew T. McCulloch, Young-Kyung Lee, Janett Stoehr, Pauline Mélénec, Cris S. Guaman, Xanthe L. Metcalf, Victoria Lee, Anaiis Zaratzian, Andrew Da Silva, Michael Tayao, Sonia Rolo, Monica Phimmachanh, Ghazal Sultani, Laura McDonald, Susan M. Mason, Nicola Ferrari, Lisa M. Ooms, Anna-Karin E. Johnsson, Heather J. Spence, Michael F. Olson, Laura M. Machesky, Owen J. Sansom, Jennifer P. Morton, Christina A. Mitchell, Michael S. Samuel, David R. Croucher, Heidi C.E. Welch, Karen Blyth, C. Elizabeth Caldon, David Herrmann, Kurt I. Anderson, Paul Timpson, Max Nobis
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109689- (2021)
Summary: Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Förster resonance energy transfer (
Externí odkaz:
https://doaj.org/article/60a7564e516e42fe894cc587d92fc98e
Autor:
Claire Vennin, Pauline Mélénec, Romain Rouet, Max Nobis, Aurélie S. Cazet, Kendelle J. Murphy, David Herrmann, Daniel A. Reed, Morghan C. Lucas, Sean C. Warren, Zehra Elgundi, Mark Pinese, Gabriella Kalna, Daniel Roden, Monisha Samuel, Anaiis Zaratzian, Shane T. Grey, Andrew Da Silva, Wilfred Leung, Australian Pancreatic Genome Initiative (APGI), Suresh Mathivanan, Yingxiao Wang, Anthony W. Braithwaite, Daniel Christ, Ales Benda, Ashleigh Parkin, Phoebe A. Phillips, John M. Whitelock, Anthony J. Gill, Owen J. Sansom, David R. Croucher, Benjamin L. Parker, Marina Pajic, Jennifer P. Morton, Thomas R. Cox, Paul Timpson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-22 (2019)
Subtypes of cancer associated fibroblasts can both promote and suppress tumorigenesis. Here, the authors investigate how p53 status in pancreatic cancer cells affects their interaction with cancer associated fibroblasts, and report perlecan as a medi
Externí odkaz:
https://doaj.org/article/9cbe7f002204495db0cd437d4360e24c
Autor:
James R.W. Conway, Sean C. Warren, David Herrmann, Kendelle J. Murphy, Aurélie S. Cazet, Claire Vennin, Robert F. Shearer, Monica J. Killen, Astrid Magenau, Pauline Mélénec, Mark Pinese, Max Nobis, Anaiis Zaratzian, Alice Boulghourjian, Andrew M. Da Silva, Gonzalo del Monte-Nieto, Arne S.A. Adam, Richard P. Harvey, Jody J. Haigh, Yingxiao Wang, David R. Croucher, Owen J. Sansom, Marina Pajic, C. Elizabeth Caldon, Jennifer P. Morton, Paul Timpson
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3312-3326 (2018)
Summary: Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to therapeutic inhibition of the PI3K pathway within the hypoxic microenvironment of pancre
Externí odkaz:
https://doaj.org/article/1dd7417190fc4a1586f84ed7e4b76935
Autor:
Ganesh R, Pathare, Alexiane, Decout, Selene, Glück, Simone, Cavadini, Kristina, Makasheva, Ruud, Hovius, Georg, Kempf, Joscha, Weiss, Zuzanna, Kozicka, Baptiste, Guey, Pauline, Melenec, Beat, Fierz, Nicolas H, Thomä, Andrea, Ablasser
Publikováno v:
Nature. 587(7835)
The DNA sensor cyclic GMP-AMP synthase (cGAS) initiates innate immune responses following microbial infection, cellular stress and cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c62a78936391fb06069061638e27bec5
https://pubmed.ncbi.nlm.nih.gov/32911482
https://pubmed.ncbi.nlm.nih.gov/32911482
Autor:
Sean C Warren, Max Nobis, Astrid Magenau, Yousuf H Mohammed, David Herrmann, Imogen Moran, Claire Vennin, James RW Conway, Pauline Mélénec, Thomas R Cox, Yingxiao Wang, Jennifer P Morton, Heidi CE Welch, Douglas Strathdee, Kurt I Anderson, Tri Giang Phan, Michael S Roberts, Paul Timpson
Publikováno v:
eLife, Vol 7 (2018)
Intravital microscopy can provide unique insights into the function of biological processes in a native context. However, physiological motion caused by peristalsis, respiration and the heartbeat can present a significant challenge, particularly for
Externí odkaz:
https://doaj.org/article/b19ab0cf001841f7a2cef5cafceef00f
Autor:
Ganesh R. Pathare, Alexiane Decout, Selene Glück, Simone Cavadini, Kristina Makasheva, Ruud Hovius, Georg Kempf, Joscha Weiss, Zuzanna Kozicka, Baptiste Guey, Pauline Melenec, Beat Fierz, Nicolas H. Thomä, Andrea Ablasser
The DNA sensor cyclic GMP–AMP synthase (cGAS) initiates innate immune responses following microbial infection, cellular stress and cancer.Upon activation by double-stranded DNA, cytosolic cGAS produces 2′3′ cGMP–AMP, which triggersthe inducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c582caebac97463477a71f7f69a47dd6
https://infoscience.epfl.ch/record/280161
https://infoscience.epfl.ch/record/280161
