Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery.

Autor: Lisa Mosconi, Valentina Berti, Crystal Quinn, Pauline McHugh, Gabriella Petrongolo, Ricardo S Osorio, Christopher Connaughty, Alberto Pupi, Shankar Vallabhajosula, Richard S Isaacson, Mony J de Leon, Russell H Swerdlow, Roberta Diaz Brinton

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0185926 (2017)

After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The biological mechanisms underlying the increased AD risk in women remain largely undetermined. Preclinical studies identified the perimenopause to menopause trans

Externí odkaz: https://doaj.org/article/73ea6eff602d4b8fb88701359096a087

Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer’s disease: a cross-sectional study of middle-aged adults from the broader New York City area

Autor: Richard S. Isaacson, Mony J. de Leon, Antonio Convit, Christine A. Ganzer, Pauline McHugh, Randolph E Andrews, Ricardo S. Osorio, Joanna Sterling, Crystal Quinn, Dawn C. Matthews, Lisa Mosconi, Michelle Walters

Publikováno v: BMJ Open

ObjectiveTo investigate the effects of lifestyle and vascular-related risk factors for Alzheimer’s disease (AD) on in vivo MRI-based brain atrophy in asymptomatic young to middle-aged adults.DesignCross-sectional, observational.SettingBroader New Y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813d59a389594c2404734bc9fc77ab60
http://europepmc.org/articles/PMC5875649

Periodontal disease associates with higher brain amyloid load in normal elderly

Autor: Pauline McHugh, Chen Shi, Henry Rusinek, Schantel Williams, Shankar Vallabhajosula, Mony J. de Leon, Elizabeth Pirraglia, Ronald G. Craig, Patricia Corby, Spencer Svetcov, Lidia Glodzik, Ross Linker, Lisa Mosconi, L i Yi, Deepak Saxena, Wai Tsui, Angela R. Kamer

Publikováno v: Neurobiology of Aging. 36:627-633

The accumulation of amyloid-β (Aβ) plaques is a central feature of Alzheimer's disease (AD). First reported in animal models, it remains uncertain if peripheral inflammatory and/or infectious conditions in humans can promote Aβ brain accumulation.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a68c8f31028000583137c4b22f3520f
https://doi.org/10.1016/j.neurobiolaging.2014.10.038

Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery

Autor: Richard S. Isaacson, Ricardo S. Osorio, Christopher Connaughty, Crystal Guyara-Quinn, Roberta Diaz Brinton, Alberto Pupi, Shankar Vallabhajosula, Mony J. de Leon, Russell H. Swerdlow, Lisa Mosconi, Valentina Berti, Gabriella Petrongolo, Pauline McHugh

Publikováno v: PLoS ONE, Vol 12, Iss 10, p e0185926 (2017)
PLoS ONE

After advanced age, female sex is the major risk factor for Alzheimer’s disease (AD). The biological mechanisms underlying the increased AD risk in women remain largely undetermined. Preclinical studies identified the perimenopause to menopause tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030abb2551ab132f939000e30b4a9193
http://europepmc.org/articles/PMC5634623?pdf=render

A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease

Autor: Andrew J. Saykin, Kathryn A. Ellis, Lorena Rami, Lisa Mosconi, Argonde C. van Harten, Mathieu Ceccaldi, Bruno Dubois, Philip Scheltens, Ronald C. Petersen, Barry Reisberg, Carole Dufouil, Melissa J. Slavin, Frank Jessen, Martin P.J. van Boxtel, Audrey Perrotin, Vincent de La Sayette, Laura A. Rabin, Dorene M. Rentz, Gaël Chételat, Wiesje M. van der Flier, Melanie B. Shulman, Michelle M. Mielke, Olga Uspenskaya, Robert Stewart, Pieter Jelle Visser, Ricardo S. Osorio, Pauline McHugh, Monique M.B. Breteler, Michael Wagner, Lidia Glodzik, Reisa A. Sperling, Bruno Vellas, Mony J. de Leon, Perminder S. Sachdev, José Luis Molinuevo, Rebecca E. Amariglio

Publikováno v: Jessen, F, Amariglio, R E, van Boxtel, M, Breteler, M, Ceccaldi, M, Chetelat, G, Dubois, B, Dufouil, C, Ellis, K A, van der Flier, W M, Glodzik, L, van Harten, A C, de Leon, M J, McHugh, P, Mielke, M M, Molinuevo, J L, Mosconi, L, Osorio, R S, Perrotin, A, Petersen, R C, Rabin, L A, Rami, L, Reisberg, B, Rentz, D M, Sachdev, P S, de la Sayette, V, Saykin, A J, Scheltens, P, Shulman, M B, Slavin, M J, Sperling, R A, Stewart, R, Uspenskaya, O, Vellas, B, Visser, P J & Wagner, M 2014, ' A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease ', Alzheimers & Dementia, vol. 10, no. 6, pp. 844-852 . https://doi.org/10.1016/j.jalz.2014.01.001
Alzheimer's & Dementia, 10(6), 844-852. Elsevier Science
Alzheimers & Dementia, 10(6), 844-852. Elsevier
Alzheimer's and dementia 10(6), 844-852 (2014). doi:10.1016/j.jalz.2014.01.001

There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer’s disease (AD). The research on SCD in early AD, howev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a229fa31f8292a57d9233ef8aacdb505
https://doi.org/10.1016/j.jalz.2014.01.001