Zobrazeno 1 - 10
of 464
pro vyhledávání: '"Pauline M, Rudd"'
Autor:
John MacSharry, Zsuzsanna Kovács, Yongjing Xie, Barbara Adamczyk, Caitriona Walsh, Fiona Reidy, Fionnuala M. McAuliffe, Mark T Kilbane, Patrick J Twomey, Pauline M. Rudd, Mary Wingfield, Michael Butler, Douwe van Sinderen, Louise Glover, Radka Saldova
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Endometriosis is a chronic systemic disease, which results in endometrial-type tissue growing outside the uterus, and affects approximately 10% of reproductive-aged women worldwide. Its aetiology is poorly understood, and there is currently
Externí odkaz:
https://doaj.org/article/ef1996e4550a4323a3450985ca3ec339
Autor:
Gillian A. Corbett, Rebecca Moore, Conor Feehily, Sarah Louise Killeen, Eileen O'Brien, Douwe Van Sinderen, Elizabeth Matthews, Roisin O'Flaherty, Pauline M. Rudd, Radka Saldova, Calum J. Walsh, Elaine M. Lawton, David A. MacIntyre, Siobhan Corcoran, Paul D. Cotter, Fionnuala M. McAuliffe
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 11 (2024)
ABSTRACT The vaginal microbiome is a key player in the etiology of spontaneous preterm birth. This study aimed to illustrate maternal environmental factors associated with vaginal microbiota composition and function in pregnancy. Women in healthy pre
Externí odkaz:
https://doaj.org/article/c99e2c423c9242f697d7dd47b6efad8a
Autor:
Zsuzsanna Kovács, Fiona Reidy, Louise Glover, Fionnuala M. McAuliffe, Henning Stockmann, Mark T. Kilbane, Patrick J. Twomey, Maire Peters, Merli Saare, Pauline M. Rudd, Meeme Utt, Mary Wingfield, Andres Salumets, Radka Saldova
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Endometriosis is a chronic inflammatory gynaecological disease characterized by the growth of endometrial tissue outside the uterine cavity. There are currently no definitive non-invasive diagnostic tools. Glycosylation is the most common po
Externí odkaz:
https://doaj.org/article/49ca3df7f2d745ffbebbe0c88f41066c
Autor:
Conor Feehily, Ian J. O’Neill, Calum J. Walsh, Rebecca L. Moore, Sarah Louise Killeen, Aisling A. Geraghty, Elaine M. Lawton, David Byrne, Rocio Sanchez-Gallardo, Sai Ravi Chandra Nori, Ida Busch Nielsen, Esther Wortmann, Elizabeth Matthews, Roisin O’Flaherty, Pauline M. Rudd, David Groeger, Fergus Shanahan, Radka Saldova, Fionnuala M. McAuliffe, Douwe Van Sinderen, Paul D. Cotter
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract A significant proportion of the infant gut microbiome is considered to be acquired from the mother during and after birth. Thus begins a lifelong and dynamic relationship with microbes that has an enduring impact on host health. Based on a c
Externí odkaz:
https://doaj.org/article/26650c16de684337b8c9307fea1f8d0c
Autor:
Róisín O’Flaherty, Manuela Amez Martín, Richard A. Gardner, Patrick M. Jennings, Pauline M. Rudd, Daniel I. R. Spencer, David Falck
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 125 (2024)
Recombinant human erythropoietin (EPO) is a biopharmaceutical frequently used in the treatment of anemia. It is a heavily glycosylated protein with a diverse and complex glycome. EPO N-glycosylation influences important pharmacological parameters, pr
Externí odkaz:
https://doaj.org/article/7761628facb24ab8a1a57ca707d15dcd
Autor:
Ian Walsh, Matthew S. F. Choo, Sim Lyn Chiin, Amelia Mak, Shi Jie Tay, Pauline M. Rudd, Yang Yuansheng, Andre Choo, Ho Ying Swan, Terry Nguyen-Khuong
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2087-2099 (2020)
The accurate assessment of antibody glycosylation during bioprocessing requires the high-throughput generation of large amounts of glycomics data. This allows bioprocess engineers to identify critical process parameters that control the glycosylation
Externí odkaz:
https://doaj.org/article/3a87638c992641a195d5dc6c94c19a48
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Intravenous immunoglobulin (IVIG) is used as an immunomodulatory agent in the treatment of various autoimmune/inflammatory diseases although its mechanism of action remains elusive. Recently, nonfucosylated IgG has been shown to be preferentially bou
Externí odkaz:
https://doaj.org/article/0f3ea5484a0c447cbf3cad791e9ff51b
Autor:
Zoe Virion, Stéphane Doly, Kusumika Saha, Mireille Lambert, François Guillonneau, Camille Bied, Rebecca M. Duke, Pauline M. Rudd, Catherine Robbe-Masselot, Xavier Nassif, Mathieu Coureuil, Stefano Marullo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Meningococcus utilizes β-arrestin selective activation of endothelial cell β2 adrenergic receptor (β2AR) to cause meningitis in humans. Here authors report that Meningococcus triggers β2AR signaling by exerting forces on β2AR glycans that termin
Externí odkaz:
https://doaj.org/article/5266fe5b61d4428e97255621e2d00f9c
Autor:
Miguel A. Rojas-Macias, Julien Mariethoz, Peter Andersson, Chunsheng Jin, Vignesh Venkatakrishnan, Nobuyuki P. Aoki, Daisuke Shinmachi, Christopher Ashwood, Katarina Madunic, Tao Zhang, Rebecca L. Miller, Oliver Horlacher, Weston B. Struwe, Yu Watanabe, Shujiro Okuda, Fredrik Levander, Daniel Kolarich, Pauline M. Rudd, Manfred Wuhrer, Carsten Kettner, Nicolle H. Packer, Kiyoko F. Aoki-Kinoshita, Frédérique Lisacek, Niclas G. Karlsson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Glycomics is gaining momentum in basic, translational and clinical research. Here, the authors review current reporting standards and analysis tools for mass-spectrometry-based glycomics, and propose an e-infrastructure for standardized reporting and
Externí odkaz:
https://doaj.org/article/8f37916676f94c028d37e7e01c2da22a
Autor:
Gordon Greville, Esther Llop, Chengnan Huang, Jack Creagh-Flynn, Stephanie Pfister, Roisin O'Flaherty, Stephen F. Madden, Rosa Peracaula, Pauline M. Rudd, Amanda McCann, Radka Saldova
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Background: Glycosylation is one of the most fundamental post-translational modifications. Importantly, glycosylation is altered in many cancers. These alterations have been proven to impact on tumor progression and to promote tumor cell survival. Fr
Externí odkaz:
https://doaj.org/article/62c26e37f725440d8260bcfd53d09ea3