Towards the Oral Treatment of Ileo-Colonic Inflammatory Bowel Disease with Infliximab Tablets: Development and Validation of the Production Process

Autor: Bahez Gareb, Silke Posthumus, Max Beugeling, Pauline Koopmans, Daan J. Touw, Gerard Dijkstra, Jos G.W. Kosterink, Henderik W. Frijlink

Publikováno v: Pharmaceutics, Vol 11, Iss 9, p 428 (2019)

Infliximab (IFX) is an intravenously administered monoclonal antibody antagonizing the effects of tumor necrosis factor-alpha (TNF) systemically and is efficacious in the treatment of inflammatory bowel disease (IBD). However, studies suggest that th

Externí odkaz: https://doaj.org/article/dc43760a73034ef4bbe5a143ce96ec1f

Vincristine pharmacokinetics and response to vincristine monotherapy in an up-front window study of the Dutch Childhood Leukaemia Study Group (DCLSG)

Autor: Wim J. Sluiter, Anjo J.P. Veerman, Donald R. A. Uges, Willem Kamps, Siebold S.N. de Graaf, Tiny Meeuwsen-de Boer, Ellis Groninger, Pauline Koopmans

Publikováno v: Groninger, E, de Boer, T, Koopmans, P, Uges, D, Sluiter, W, Veerman, A J P, Kamps, W A & de Graaf, S 2005, ' Vincristine pharmacokinetics and response to vincristine monotherapy in an up-front window study of the Dutch Childhood Leukaemia Study Group (DCLSG) ', European Journal of Cancer, vol. 41, no. 1, pp. 98-103 . https://doi.org/10.1016/j.ejca.2004.10.006
European Journal of Cancer, 41, 1, pp. 98-103
European Journal of Cancer, 41(1), 98-103. Elsevier Limited
European Journal of Cancer, 41(1), 98-103. ELSEVIER SCI LTD
European Journal of Cancer, 41, 98-103

Contains fulltext : 48224.pdf (Publisher’s version ) (Closed access) The relationship between vincristine pharmacokinetics and its antileukaemic effect in children is unknown. Since vincristine plays a key role in the treatment of childhood acute l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2e462f3ef6d19c0a00a347733be5be
https://doi.org/10.1016/j.ejca.2004.10.006

Pharmacokinetics of vincristine monotherapy in childhood acute lymphoblastic leukemia

Autor: Pauline Koopmans, Donald R. A. Uges, Anjo J.P. Veerman, Ellis Groninger, Tiny G. J. Meeuwsen-de Boer, Siebold S.N. de Graaf, Wim J. Sluiter, Willem Kamps

Publikováno v: Pediatric Research, 52, 113-8
Pediatric Research, 52, 1, pp. 113-8

Item does not contain fulltext We studied vincristine pharmacokinetics in 70 children newly diagnosed with acute lymphoblastic leukemia, after a single dose of vincristine as monotherapy. Vincristine plasma concentrations were measured by HPLC analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70534f714b0786d5d164ed69354cb1a
https://hdl.handle.net/2066/144555

Pitfalls of 'long-distance pharmacokinetics.' - Shipment of biologic samples to reference laboratories

Autor: Stewart J. Kellie, Donald R. A. Uges, Britt-Marie Frost, Pauline Koopmans, Siebold S.N. de Graaf

Publikováno v: Medical and Pediatric Oncology, 38(5), 369-370

Topical topics: pitfalls of "Long-Distance pharmacokinetics." Shipment of biologic samples to reference laboratories

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d75008c7089a89ccbc0eff1e8936c8
https://research.rug.nl/en/publications/78c32c32-bf2d-4c60-b145-3ab1fd58c48f

Cerebrospinal fluid concentrations of vincristine after bolus intravenous dosing: a surrogate marker of brain penetration

Autor: Draga Barbaric, John W. Earl, Siebold S. N. de Graaf, Deborah J. Carr, Stewart J. Kellie, Pauline Koopmans

Publikováno v: Cancer, 94, 1815-20
Cancer, 94(6), 1815-1820. Wiley
Cancer, 94, 6, pp. 1815-20

BACKGROUND Vincristine (VCR) is used widely in oncology practice, and regular dosing is commonly associated with the development of sensorimotor or autonomic neuropathies. However, the incidence of VCR-related central nervous system (CNS) toxicity is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d4133fb1d0064a6cb82649e07cb675
http://hdl.handle.net/2066/160327