Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Pauline J. Beckmann"'
Autor:
David A. Largaespada, Aaron L. Sarver, Michael D. Taylor, Annie Huang, David J. Odde, Robert J. Wechsler-Reya, Robert B. Jenkins, Charles G. Eberhart, Stephen C. Schmechel, Anthony E. Rizzardi, Michelle M. Frees, Addison M. Demer, Amy M. Molan, Ryan D. Krebs, Quincy Rosemarie, Fausto J. Rodriguez, Xiaochong Wu, Daniel Picard, Branden S. Moriarity, Adrian M. Dubuc, Paramita Das, Barbara R. Tschida, Catherine Lee, Jun Wang, Rory L. Williams, George M. Otto, Ghaidan A. Shamsan, Eric P. Rahrmann, Sandra Wagner, Jason P. Ostergaard, Alex T. Larsson, Jon D. Larson, Pauline J. Beckmann
Medulloblastoma and central nervous system primitive neuroectodermal tumors (CNS-PNET) are aggressive, poorly differentiated brain tumors with limited effective therapies. Using Sleeping Beauty (SB) transposon mutagenesis, we identified novel genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebcfc7720d1848ea19440c3e7a8f431f
https://doi.org/10.1158/0008-5472.c.6511413.v1
https://doi.org/10.1158/0008-5472.c.6511413.v1
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Oncoprints showing steatosis-associated CIS gene amplifications, deep deletions, and mutations occurring in at least 5% of all(S5), steatosis-associated(S6), and alcohol-associated(S7) TCGA HCC cases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454cd20e521cb04dc3547458aa1f7623
https://doi.org/10.1158/0008-5472.22415118
https://doi.org/10.1158/0008-5472.22415118
Autor:
David A. Largaespada, Aaron L. Sarver, Michael D. Taylor, Annie Huang, David J. Odde, Robert J. Wechsler-Reya, Robert B. Jenkins, Charles G. Eberhart, Stephen C. Schmechel, Anthony E. Rizzardi, Michelle M. Frees, Addison M. Demer, Amy M. Molan, Ryan D. Krebs, Quincy Rosemarie, Fausto J. Rodriguez, Xiaochong Wu, Daniel Picard, Branden S. Moriarity, Adrian M. Dubuc, Paramita Das, Barbara R. Tschida, Catherine Lee, Jun Wang, Rory L. Williams, George M. Otto, Ghaidan A. Shamsan, Eric P. Rahrmann, Sandra Wagner, Jason P. Ostergaard, Alex T. Larsson, Jon D. Larson, Pauline J. Beckmann
Figure S4. Shows ARHGAP36 expression in mouse and human neural tissue. Figure S5. Shows characterization of ARHGAP36 and Megf10 in C17.2 cells Figures S6-S7 show mechanistic analysis of FOXR2 in C17.2 and HSC1L cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c88fb8090e9d0f93c8d64bec0f20df6
https://doi.org/10.1158/0008-5472.22423053
https://doi.org/10.1158/0008-5472.22423053
Autor:
David A. Largaespada, Aaron L. Sarver, Michael D. Taylor, Annie Huang, David J. Odde, Robert J. Wechsler-Reya, Robert B. Jenkins, Charles G. Eberhart, Stephen C. Schmechel, Anthony E. Rizzardi, Michelle M. Frees, Addison M. Demer, Amy M. Molan, Ryan D. Krebs, Quincy Rosemarie, Fausto J. Rodriguez, Xiaochong Wu, Daniel Picard, Branden S. Moriarity, Adrian M. Dubuc, Paramita Das, Barbara R. Tschida, Catherine Lee, Jun Wang, Rory L. Williams, George M. Otto, Ghaidan A. Shamsan, Eric P. Rahrmann, Sandra Wagner, Jason P. Ostergaard, Alex T. Larsson, Jon D. Larson, Pauline J. Beckmann
Characterization of SB-induced medulloblastomas and CNS-PNETs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bcf71417a72492031f7dbb0484851a0
https://doi.org/10.1158/0008-5472.22423056.v1
https://doi.org/10.1158/0008-5472.22423056.v1
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Supplementary tables detailing qRT-PCR primer sequences (S1), IHC antibodies (S2), and parameters for histological stain quantification (S3-6) described in methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4748c8642abdcd640f9066eead0b02
https://doi.org/10.1158/0008-5472.22415115
https://doi.org/10.1158/0008-5472.22415115
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Wnt/beta-catenin(S11) and PKA/cAMP(S12) signaling alterations in liver cancer, and transgene expression in mouse livers after PKA/shp53 injection(S13)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b0044086c645f22a82bc79a8e64022
https://doi.org/10.1158/0008-5472.22415124
https://doi.org/10.1158/0008-5472.22415124
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Tables of mice(S7); CIS genes(S8); insertions(S9); human HCC CIS gene alterations(S10); steatosis-enriched CIS(S11); pathways altered in HCC(S12-18)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e47c32a0e1af41d542b190be3d5477fe
https://doi.org/10.1158/0008-5472.22415112
https://doi.org/10.1158/0008-5472.22415112
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Supplementary Figure S1 shows FOXA1 and FOXA2 repression in steatotic mouse livers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14336f0f09fe9204fac85841f2a6ca4
https://doi.org/10.1158/0008-5472.22415127
https://doi.org/10.1158/0008-5472.22415127
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Hepatic steatosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet little is known about the molecular pathology associated with this factor. In this study, we performed a forward genetic screen using Sleeping Beauty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349548c9e97257a61c9487d5e590f052
https://doi.org/10.1158/0008-5472.c.6509181.v1
https://doi.org/10.1158/0008-5472.c.6509181.v1
Autor:
David A. Largaespada, Vincent W. Keng, Adam J. Dupuy, Joseph H. Nadeau, Lewis R. Roberts, Ju Dong Yang, Aaron L. Sarver, Rachel A. Heuer, Pauline J. Beckmann, Khalid Amin, Michael A. Linden, Wendy A. Hudson, Sandra Wagner, Robert Hullsiek, Carlos A. Tierrablanca, Jesse D. Riordan, Lindsey A. Lee, Timothy P. Kuka, Nuri A. Temiz, Barbara R. Tschida
Transposon insertion profiles from animals with tumors sharing 0-2(S2), 3(S3), or >3(S4) insertions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19916e39b7494c746182ba412ebd4591
https://doi.org/10.1158/0008-5472.22415121
https://doi.org/10.1158/0008-5472.22415121