Transfer of the Integrative and Conjugative Element ICESt3 of Streptococcus thermophilus in Physiological Conditions Mimicking the Human Digestive Ecosystem

Autor: Pauline Herviou, Aurélie Balvay, Deborah Bellet, Sophie Bobet, Claire Maudet, Johan Staub, Monique Alric, Nathalie Leblond-Bourget, Christine Delorme, Sylvie Rabot, Sylvain Denis, Sophie Payot

Publikováno v: Microbiology Spectrum, Vol 11, Iss 3 (2023)

ABSTRACT Metagenome analyses of the human microbiome suggest that horizontal gene transfer (HGT) is frequent in these rich and complex microbial communities. However, so far, only a few HGT studies have been conducted in vivo. In this work, three dif

Externí odkaz: https://doaj.org/article/258be903b2144b37b352a9d7c2638597

hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma

Autor: Pauline Herviou, Morgane Le Bras, Leïla Dumas, Corinne Hieblot, Julia Gilhodes, Gianluca Cioci, Jean-Philippe Hugnot, Alfred Ameadan, François Guillonneau, Erik Dassi, Anne Cammas, Stefania Millevoi

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

RNA G-quadruplexes (RG4s) have been functionally linked to cancer gene expression. Here, Herviou, Le Bras et al. have identified the protein machinery modulating RG4s and reveal the role and mechanism of hnRNP H/F and DHX36 in RG4-mediated translatio

Externí odkaz: https://doaj.org/article/943f94a9317e43c69d93a0684d2b3375

QUADRatlas: the RNA G-quadruplex and RG4-binding proteins database

Autor: Sébastien Bourdon, Pauline Herviou, Leïla Dumas, Eliana Destefanis, Andrea Zen, Anne Cammas, Stefania Millevoi, Erik Dassi

Publikováno v: Nucleic Acids Research. 51:D240-D247

RNA G-quadruplexes (RG4s) are non-canonical, disease-associated post-transcriptional regulators of gene expression whose functions are driven by RNA-binding proteins (RBPs). Being able to explore transcriptome-wide RG4 formation and interaction with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbecf2f5916dda1605e0dece945769d5
https://doi.org/10.1093/nar/gkac782

The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors

Autor: Bianca Balbino, Julien Stackowicz, Kari C. Nadeau, Pauline Herviou, Ophélie Godon, Sébastien Brûlé, Delphine Sterlin, Andrew J. Murphy, Vera Voronina, Bruno Iannascoli, Odile Richard-Le Goff, Gaël A. Millot, Macdonald Lynn, Laurent L. Reber, Harris Faith, Pierre Bruhns

Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, 2019, ⟨10.1172/JCI129697⟩
Journal of Clinical Investigation, American Society for Clinical Investigation, 2019, ⟨10.1172/JCI129697⟩
J Clin Invest

International audience; Omalizumab is an anti-IgE monoclonal antibody (mAb) approved for the treatment of severe asthma and chronic spontaneous urticaria. Use of Omalizumab is associated with reported side effects, ranging from local skin inflammatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4c06554f4a34ad7e3a43c7c44772130
https://doi.org/10.1172/jci129697

Analysis of mRNA Translation by Polysome Profiling

Autor: Anne, Cammas, Pauline, Herviou, Leïla, Dumas, Stefania, Millevoi

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2404

mRNA translation is a key step in gene expression that allows the cell to qualitatively and quantitatively modulate the cell's proteome according to intra- or extracellular signals. Polysome profiling is the most comprehensive technique to study both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fd19185ff1e127c721b152568475379a
https://pubmed.ncbi.nlm.nih.gov/34694604