Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Pauline H. Tan"'
Autor:
Bernard Khor, John D Gagnon, Gautam Goel, Marly I Roche, Kara L Conway, Khoa Tran, Leslie N Aldrich, Thomas B Sundberg, Alison M Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H Tan, Atul K Bhan, Rahul Roychoudhuri, Nicholas P Restifo, John J O'Shea, Benjamin D Medoff, Alykhan F Shamji, Stuart L Schreiber, Arlene H Sharpe, Stanley Y Shaw, Ramnik J Xavier
Publikováno v:
eLife, Vol 4 (2015)
The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dua
Externí odkaz:
https://doaj.org/article/8d529be262854d4f87b10c044565271a
Publikováno v:
Journal of Combinatorial Chemistry. 11:604-611
On-bead screening of one-bead-one-compound (OBOC) libraries provides a powerful method for the rapid identification of active compounds against molecular or cellular targets. However, on-bead screening is susceptible to interference from nonspecific
Autor:
Marly I. Roche, Melanie Schirmer, Gautam Goel, Atul K. Bhan, Alykhan F. Shamji, John J. O'Shea, David Dombkowski, Thomas B. Sundberg, Stuart L. Schreiber, John D. Gagnon, Bernard Khor, Alison M. Paterson, Arlene H. Sharpe, Benjamin D. Medoff, Khoa D. Tran, Scott Mordecai, Kara L. Conway, Nicholas P. Restifo, Ramnik J. Xavier, Stanley Y. Shaw, Leslie N Aldrich, Rahul Roychoudhuri, Pauline H. Tan
Publikováno v:
eLife, Vol 4 (2015)
eLife
eLife
The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dua
Autor:
John D. Gagnon, Marly I. Roche, Gautam Goel, Benjamin D. Medoff, Melanie Schirmer, Scott Mordecai, Kara L. Conway, Rahul Roychoudhuri, Alison M. Paterson, Atul K. Bhan, Pauline H. Tan, Thomas B. Sundberg, David Dombkowski, John J. O'Shea, Bernard Khor, Khoa D. Tran, Nicholas P. Restifo, Ramnik J. Xavier, Alykhan F. Shamji, Leslie N. Aldrich, Stuart L. Schreiber, Arlene H. Sharpe, Stanley Y. Shaw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fe25d06b6360221619c517a3169711d
https://doi.org/10.7554/elife.05920.028
https://doi.org/10.7554/elife.05920.028
Publikováno v:
Methods in Molecular Biology ISBN: 9781493922680
Despite rapid advances in the genetics of complex human diseases, understanding the significance of human disease alleles remains a critical roadblock to clinical translation. Here, we present a chemical biology approach that uses perturbation with s
Autor:
Kara G. Lassen, Petric Kuballa, Pauline H. Tan, Stuart L. Schreiber, Bernard Khor, Alykhan F. Shamji, Mark J. Daly, Khoa D. Tran, Gautam Goel, Daniel B. Graham, Joanna M. Peloquin, Adam B. Castoreno, Ramnik J. Xavier, Stanley Y. Shaw, Leslie N. Aldrich
Publikováno v:
ACS chemical biology. 8(12)
Autophagy is an evolutionarily conserved catabolic process that directs cytoplasmic proteins, organelles and microbes to lysosomes for degradation. Autophagy acts at the intersection of pathways involved in cellular stress, host defense, and modulati
Publikováno v:
Journal of proteomics. 81
Cytoplasmic tyrosine kinases (CTK) generally contain a Src-homology 2 (SH2) domain, whose role in the CTK family is not fully understood. Here we report the determination of the specificity of 25 CTK SH2 domains by screening one-bead-one-compound (OB