The amygdala–ventral pallidum pathway contributes to a hypodopaminergic state in the ventral tegmental area during protracted abstinence from chronic cocaine

Autor: Adélie Salin, Emilie Dugast, Virginie Lardeux, Marcello Solinas, Pauline Belujon

Publikováno v: British Journal of Pharmacology
British Journal of Pharmacology, 2023, ⟨10.1111/bph.16034⟩

International audience; BACKGROUND AND PURPOSE: Incubation of craving, the progressive increase in drug seeking over the first weeks of abstinence, is associated with temporal changes during abstinence in the activity of several structures involved i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7feded083628df0ac68c5f5e7aba09bf
https://doi.org/10.1111/bph.16034

Protracted Abstinence From Extended Cocaine Self-Administration Is Associated With Hypodopaminergic Activity in the VTA but Not in the SNc

Autor: Marcello Solinas, Adélie Salin, Virginie Lardeux, Pauline Belujon

Publikováno v: International Journal of Neuropsychopharmacology
International Journal of Neuropsychopharmacology, Oxford University Press (OUP), 2020, ⟨10.1093/ijnp/pyaa096⟩

The chronic relapsing nature of cocaine addiction suggests that chronic cocaine exposure produces persistent neuroadaptations that may be temporally and regionally dynamic in brain areas such as the dopaminergic (DA) system. We have previously shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c56edc9576cb757478a65ecf31d6c69
https://hal.archives-ouvertes.fr/hal-03149761

Dopamine and addiction: what have we learned from 40 years of research

Autor: Pauline Belujon, Mohamed Jaber, Pierre-Olivier Fernagut, Marcello Solinas, Nathalie Thiriet

Publikováno v: Journal of Neural Transmission
Journal of Neural Transmission, Springer Verlag, 2019, 126 (4), pp.481-516. ⟨10.1007/s00702-018-1957-2⟩

International audience; Among the neurotransmitters involved in addiction, dopamine (DA) is clearly the best known. The critical role of DA in addiction is supported by converging evidence that has been accumulated in the last 40 years. In the presen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60cf8d4543bd5ca6fe30d2ed276dead6
https://www.hal.inserm.fr/inserm-02163255

Withdrawal from Acute Amphetamine Induces an Amygdala-Driven Attenuation of Dopamine Neuron Activity: Reversal by Ketamine

Autor: Hannah K. Dollish, Pauline Belujon, Anthony A. Grace, Nicole L Jakobowski

Publikováno v: Neuropsychopharmacology. 41:619-627

Drug addiction is a chronic disorder characterized by a cycle composed of drug seeking, intoxication with drug taking and withdrawal associated with negative affect. Numerous studies have examined withdrawal/negative affect after chronic use; however

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fc036c89c47c8d9a87ef3bd1cd777d
https://doi.org/10.1038/npp.2015.191

Cocaine-induced disruptions of information flow from the basolateral amygdala to the insula

Autor: Marcello Solinas, Pauline Belujon, A. Salin

Publikováno v: European-College-of-Neuropsychopharmacology Workshop for Junior Scientists in Europe
European-College-of-Neuropsychopharmacology Workshop for Junior Scientists in Europe, Mar 2017, Nice, FRANCE, France. 28, pp.S51, 2018, ⟨10.1016/j.euroneuro.2017.12.081⟩

Understanding persistent dysregulations induced by chronic drug use on neuronal networks is crucial in order to develop appropriate therapeutic approach for addiction. The basolateral amygdala (BLA), involved in emotional processing, as well as the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916543788fbe53f4fe0af51d8c0a42df
https://hal.archives-ouvertes.fr/hal-02527789