Biochemical and crystallographic studies of l,d-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate

Autor: Mariska de Munnik, Pauline A. Lang, Karina Calvopiña, Patrick Rabe, Jürgen Brem, Christopher J. Schofield

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)

Abstract The essential l,d-transpeptidase of Mycobacterium tuberculosis (LdtMt2) catalyses the formation of 3 $$\to$$ → 3 cross-links in cell wall peptidoglycan and is a target for development of antituberculosis therapeutics. Efforts to inhibit Ld

Externí odkaz: https://doaj.org/article/1e73630de0924f099b634058bd952bf2

Anaerobic fixed-target serial crystallography

Autor: Patrick Rabe, John H. Beale, Agata Butryn, Pierre Aller, Anna Dirr, Pauline A. Lang, Danny N. Axford, Stephen B. Carr, Thomas M. Leissing, Michael A. McDonough, Bradley Davy, Ali Ebrahim, Julien Orlans, Selina L. S. Storm, Allen M. Orville, Christopher J. Schofield, Robin L. Owen

Publikováno v: IUCrJ, Vol 7, Iss 5, Pp 901-912 (2020)

Cryogenic X-ray diffraction is a powerful tool for crystallographic studies on enzymes including oxygenases and oxidases. Amongst the benefits that cryo-conditions (usually employing a nitrogen cryo-stream at 100 K) enable, is data collection of diox

Externí odkaz: https://doaj.org/article/541ddf2ff1b14f87878d1b366c92c115

Resistance profiles to antifungal agents in Candida albicans isolated from human oral cavities: systematic review and meta-analysis

Autor: Sarah Quadros Santos Kessler, Pauline Mastella Lang, Tatiane Silva Dal-Pizzol, Francisco Montagner

Publikováno v: Clinical Oral Investigations. 26:6479-6489

To identify the antifungal susceptibility profile of Candida spp. isolated from the human oral cavity was assessed with meta-analyses of observational studies that collected samples from the oral cavity of human subjects.Isolated Candida albicans tes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46da27082c867785c91d9ea9a3d1439
https://doi.org/10.1007/s00784-022-04716-2

Pretargeted PET Imaging with a TCO-Conjugated Anti-CD44v6 Chimeric mAb U36 and [89Zr]Zr-DFO-PEG5-Tz

Autor: Dave Lumen, Danielle Vugts, Marion Chomet, Surachet Imlimthan, Mirkka Sarparanta, Ricardo Vos, Maxime Schreurs, Mariska Verlaan, Pauline A. Lang, Eero Hippeläinen, Wissam Beaino, Albert D. Windhorst, Anu J. Airaksinen

Publikováno v: Lumen, D, Vugts, D, Chomet, M, Imlimthan, S, Sarparanta, M, Vos, R, Schreurs, M, Verlaan, M, Lang, P A, Hippeläinen, E, Beaino, W, Windhorst, A D & Airaksinen, A J 2022, ' Pretargeted PET Imaging with a TCO-Conjugated Anti-CD44v6 Chimeric mAb U36 and [89Zr]Zr-DFO-PEG5-Tz ', Bioconjugate chemistry, vol. 33, no. 5, pp. 956-968 . https://doi.org/10.1021/acs.bioconjchem.2c00164
Bioconjugate chemistry, 33(5), 956-968. American Chemical Society

The recent advances in the production of engineered antibodies have facilitated the development and application of tailored, target-specific antibodies. Positron emission tomography (PET) of these antibody-based drug candidates can help to better und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9303fabee94f0e86e8d38f0c62156b58
https://research.vumc.nl/en/publications/fb160ada-3f47-43a5-8d49-1816af8ce10b

In vitro evaluation of Enterococcus faecalis biofilm with laser fluorescence after exposure to endodontic irrigants

Autor: Luciano Casagrande, Clarissa Cavalcanti Fatturi Parolo, Pauline Mastella Lang, Jonas de Almeida Rodrigues, Francisco Montagner, Elise Fagundes Cappelletti, Adrian Lussi

Publikováno v: Lasers in Dental Science. 4:217-224

The aim of this study was to evaluate the performance of the DIAGNOdent Pen (KaVo, Biberach, Germany) with respect to the fluorescence detection and quantification of microorganisms after the use of root canal solutions. Forty roots from extracted bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97637a296531e3887478c0977d47ba4a
https://doi.org/10.1007/s41547-020-00109-4