Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Pauline A. Callinan"'
Autor:
Pauline A. Callinan, Sarven Sabunciyan, Christine Ladd-Acosta, Robert H. Yolken, Andrew P. Feinberg, James B. Potash, Tiffany Dinkins, Jonathan Pevsner, Jian Bing Fan, Maree J. Webster
Publikováno v:
The American Journal of Human Genetics. 81:1304-1315
DNA methylation is a heritable modification of genomic DNA central to development, imprinting, transcriptional regulation, chromatin structure, and overall genomic stability. Aberrant DNA methylation of individual genes is a hallmark of cancer and ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f9a0c2413bf558c120e37efeaf8a41
https://doi.org/10.1086/524110
https://doi.org/10.1086/524110
Autor:
Hui Wang, Richard Cordaux, Matthew D. Dyer, Shurjo K. Sen, Jianxin Wang, Kyudong Han, Pauline A. Callinan, Mark A. Batzer, Ping Liang, Jungnam Lee
Publikováno v:
The American Journal of Human Genetics. 79:41-53
Recombination between Alu elements results in genomic deletions associated with many human genetic disorders. Here, we compare the reference human and chimpanzee genomes to determine the magnitude of this recombination process in the human lineage si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b106c4f43fad6d4836ac89fa864146c4
https://doi.org/10.1086/504600
https://doi.org/10.1086/504600
Autor:
Richard Cordaux, Mark A. Batzer, Kyudong Han, Shurjo K. Sen, Jungnam Lee, Pauline A. Callinan, Ping Liang, Jianxin Wang
Publikováno v:
Nucleic Acids Research
Long INterspersed Elements (LINE-1s or L1s) are abundant non-LTR retrotransposons in mammalian genomes that are capable of insertional mutagenesis. They have been associated with target site deletions upon insertion in cell culture studies of retrotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8990043cb5d56c93726166c785e210f
http://europepmc.org/articles/PMC1179734
http://europepmc.org/articles/PMC1179734
Autor:
Randall K. Garber, Scott W. Herke, Jianxin Wang, Ping Liang, Mark A. Batzer, Pauline A. Callinan
Publikováno v:
Journal of Molecular Biology. 348:791-800
Alu repeats contribute to genomic instability in primates via insertional and recombinational mutagenesis. Here, we report an analysis of Alu element-induced genomic instability through a novel mechanism termed retrotransposition-mediated deletion, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01d37dd5af99bcaa516fdcf41483ca5
https://doi.org/10.1016/j.jmb.2005.02.043
https://doi.org/10.1016/j.jmb.2005.02.043
Autor:
David J. Witherspoon, David A. Ray, Abdel Halim Salem, Mark A. Batzer, Lynn B. Jorde, Randall K. Garber, Dale J. Hedges, Jinchuan Xing, Pauline A. Callinan, Jeremy S. Myers
Publikováno v:
Proceedings of the National Academy of Sciences. 100:12787-12791
Alu elements have inserted in primate genomes throughout the evolution of the order. One particular Alu lineage (Ye) began amplifying relatively early in hominid evolution and continued propagating at a low level as many of its members are found in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6107fb102e6e661102ccbe92bb7618f
https://doi.org/10.1073/pnas.2133766100
https://doi.org/10.1073/pnas.2133766100
Publikováno v:
Human molecular genetics.
One of the most exciting frontiers in both epigenetics and genome sciences is the new field of epigenomics. This new discipline promises novel insights into the genome because of its potential to detect quantitative alterations, multiplex modificatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c49cf8d7c723d9d313d144d78666da
https://pubmed.ncbi.nlm.nih.gov/16651376
https://pubmed.ncbi.nlm.nih.gov/16651376
Autor:
Mark A. Batzer, Pauline A. Callinan
Nearly 50% of the human genome is composed of fossils from the remains of past transposable element duplication. Mobilization continues in the genomes of extant humans but is now restricted to retro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25a602a0a11a5be810383fb6693886e
https://doi.org/10.1159/000092503
https://doi.org/10.1159/000092503
Autor:
F. Nicole Standberry, Qi Wu, Karri S. Hawley, James P. DeLany, Henry Rothschild, Eric Ravussin, Sangkyu Kim, Ping Ar Yang, Paula J. Geiselman, Lynn B. Gerald, Scott W. Herke, S. Michal Jazwinski, Beth Kimball, Hui-Chen Hsu, John D. Mountz, Meghan Black, Robert H. Wood, Valentina Greco, Harry W. Schroeder, Hui-Yi Lin, Madlyn I. Frisard, Yu Wen Chiu, Mark A. Batzer, Annie Cooper, Crystal P. Traylor, Evest A. Broussard, Beth Schmidt, Laurie Byerley, Donald K. Scott, Elizabeth T. H. Fontham, Li Li, W. Andrew Deutsch, Yolanda Robertson, L. Joseph Su, Kay Lopez, Pauline A. Callinan, Pili Zhang, Darla E. Kendzor, Katie E. Cherry, Juling Zhou
Publikováno v:
Mechanisms of ageing and development. 127(3)
The nonagenarian population by definition represents individuals who have demonstrated success in aging. We determined the status of CD8(+) T-cell senescence in nonagenarians by analyzing the expression of CD28 and Fas (CD95), and analyzing activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9083fa7a1249db21faecfc530127d215
https://pubmed.ncbi.nlm.nih.gov/16313945
https://pubmed.ncbi.nlm.nih.gov/16313945
Autor:
Jinchuan Xing, Richard Cordaux, Dale J. Hedges, Pauline A. Callinan, Erin W Barnes, Mark A. Batzer
Alu elements are primate-specific members of the SINE (short interspersed element) family of retroposons. They have enjoyed enormous success over the course of primate evolution and, by conservative estimates, comprise some 10% of the human genome (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03452729c3976a2e955a3ee3970c5175
https://europepmc.org/articles/PMC419785/
https://europepmc.org/articles/PMC419785/
Autor:
W. Scott Watkins, Mark A. Batzer, Abdel Halim Salem, Pauline A. Callinan, Jerilyn A. Walker, Dale J. Hedges, Michael J. Bamshad, Randall K. Garber, Jinchuan Xing, Lynn B. Jorde
Publikováno v:
Gene. 317(1-2)
A comprehensive analysis of the human sex chromosomes was undertaken to assess Alu-associated human genomic diversity and to identify novel Alu insertion polymorphisms for the study of human evolution. Three hundred forty-five recently integrated Alu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743eba5d621a44a019e32c9f11608995
https://pubmed.ncbi.nlm.nih.gov/14604797
https://pubmed.ncbi.nlm.nih.gov/14604797