Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Pauline, Schneider"'
Autor:
Pauline Schneider, Nicholas T. Crump, Susan T.C.J.M. Arentsen-Peters, Alastair L. Smith, Rico Hagelaar, Fabienne R.S. Adriaanse, Romy S. Bos, Anja de Jong, Stefan Nierkens, Bianca Koopmans, Thomas A. Milne, Rob Pieters, Ronald W. Stam
Publikováno v:
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-13 (2023)
Abstract In KMT2A-rearranged acute lymphoblastic leukemia (ALL), an aggressive malignancy, oncogenic KMT2A-fusion proteins inappropriately recruit DOT1L to promote leukemogenesis, highlighting DOT1L as an attractive therapeutic target. Unfortunately,
Externí odkaz:
https://doaj.org/article/66866a3dae3648df84fc292dc2646b8d
Autor:
Fabienne R. S. Adriaanse, Pauline Schneider, Susan T. C. J. M. Arentsen-Peters, Ana M. Neves da Fonseca, Janine Stutterheim, Rob Pieters, C. Michel Zwaan, Ronald W. Stam
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6020 (2024)
Pediatric acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) exhibit favorable survival rates. However, for AML and ALL patients carrying KMT2A gene translocations clinical outcome remains unsatisfactory. Key players in KMT2A-fusion-
Externí odkaz:
https://doaj.org/article/021d666ee04345a28a88f43f0084df16
Autor:
Pauline Schneider, Priscilla Wander, Susan T. C. J. M. Arentsen-Peters, Kirsten S. Vrenken, Dedeke Rockx-Brouwer, Fabienne R. S. Adriaanse, Veerle Hoeve, Irene Paassen, Jarno Drost, Rob Pieters, Ronald W. Stam
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 17, p 13207 (2023)
In acute lymphoblastic leukemia (ALL), chromosomal translocations involving the KMT2A gene represent highly unfavorable prognostic factors and most commonly occur in patients less than 1 year of age. Rearrangements of the KMT2A gene drive epigenetic
Externí odkaz:
https://doaj.org/article/48321f7aa0cb4008bd0e8579ccc7ca3c
Autor:
Pauline Schneider, Patricia Garrido Castro, Sandra M. Pinhanços, Mark Kerstjens, Eddy H. vanRoon, Anke H.W. Essing, M. Emmy M. Dolman, Jan J. Molenaar, Rob Pieters, Ronald W. Stam
Publikováno v:
eJHaem, Vol 1, Iss 2, Pp 527-536 (2020)
Abstract MLL‐rearranged acute lymphoblastic leukemia (ALL) represents a highly aggressive ALL subtype, characterized by aberrant DNA methylation patterns. DNA methyltransferase inhibitors, such as decitabine have previously been demonstrated to be
Externí odkaz:
https://doaj.org/article/17ab3a3cd77a4a4f9267630c85d65ee2
Autor:
Priscilla Wander, Susan T.C.J.M. Arentsen-Peters, Sandra S. Pinhanҫos, Bianca Koopmans, M.Emmy M. Dolman, Rijndert Ariese, Frank L. Bos, Patricia Garrido Castro, Luke Jones, Pauline Schneider, Miriam Guillen Navarro, Jan J. Molenaar, Anne C. Rios, C. Michel Zwaan, Ronald W. Stam
Publikováno v:
Translational Oncology, Vol 14, Iss 5, Pp 101048- (2021)
Pediatric MLL-rearranged acute myeloid leukemia (AML) has a generally unfavorable outcome, primarily due to relapse and drug resistance. To overcome these difficulties, new therapeutic agents are urgently needed. Yet, implementing novel drugs for cli
Externí odkaz:
https://doaj.org/article/57a41e03969a4ac29001dea5f981bde1
Autor:
Priscilla Wander, Susan T. C. J. M. Arentsen-Peters, Kirsten S. Vrenken, Sandra Mimoso Pinhanҫos, Bianca Koopmans, M. Emmy M. Dolman, Luke Jones, Patricia Garrido Castro, Pauline Schneider, Mark Kerstjens, Jan J. Molenaar, Rob Pieters, Christian Michel Zwaan, Ronald W. Stam
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 638 (2022)
KMT2A-rearranged acute lymphoblastic leukemia (ALL) in infants (KMT2A-rearranged infant ALL patient samples (n = 2). The most effective drugs were then tested on non-leukemic whole bone marrow samples (n = 2) to select drugs with a favorable therapeu
Externí odkaz:
https://doaj.org/article/7815cb20aae54d3d99175e3e8348e9d7
Autor:
Pauline Schneider
Publikováno v:
Soziologische Revue. 45:244-248
Autor:
Mark Kerstjens, Patricia Garrido Castro, Sandra S. Pinhanços, Pauline Schneider, Priscilla Wander, Rob Pieters, Ronald W. Stam
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 711 (2021)
Acute lymphoblastic leukemia (ALL) in infants (MLL (or KMT2A) gene, which confer highly dismal prognoses on current combination chemotherapeutic regimens. Hence, more adequate therapeutic strategies are urgently needed. To expedite clinical transitio
Externí odkaz:
https://doaj.org/article/8ca0d87c0f0c463c97350d6b693d337c
Autor:
Antonio Agraz-Doblas, Clara Bueno, Rachael Bashford-Rogers, Anindita Roy, Pauline Schneider, Michela Bardini, Paola Ballerini, Gianni Cazzaniga, Thaidy Moreno, Carlos Revilla, Marta Gut, Maria G. Valsecchi, Irene Roberts, Rob Pieters, Paola De Lorenzo, Ignacio Varela, Pablo Menendez, Ronald W. Stam
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of t(4;11)/KMT2A-AFF1+ (MLL-AF4+) in
Externí odkaz:
https://doaj.org/article/e28a2faf5de741be80bab67752885060
Publikováno v:
Lehr-Lern-Labore und Digitalisierung ISBN: 9783658401085
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab4dcf3dcbccec0dcd6ec77a8b26e2d
https://doi.org/10.1007/978-3-658-40109-2_14
https://doi.org/10.1007/978-3-658-40109-2_14