Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Pauline, Robbe"'
Autor:
Shadi Basyuni, Laura Heskin, Andrea Degasperi, Daniella Black, Gene C. C. Koh, Lucia Chmelova, Giuseppe Rinaldi, Steven Bell, Louise Grybowicz, Greg Elgar, Yasin Memari, Pauline Robbe, Zoya Kingsbury, Carlos Caldas, Jean Abraham, Anna Schuh, Louise Jones, PARTNER Trial Group, Personalised Breast Cancer Program Group, Marc Tischkowitz, Matthew A. Brown, Helen R. Davies, Serena Nik-Zainal
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Whole genome sequencing (WGS) provides comprehensive, individualised cancer genomic information. However, routine tumour biopsies are formalin-fixed and paraffin-embedded (FFPE), damaging DNA, historically limiting their use in WGS. Here we
Externí odkaz:
https://doaj.org/article/1788544aae364aa680930fe83e4b04ab
Autor:
Pauline Robbe, Anna Schuh
Publikováno v:
HemaSphere, Vol 7, Iss 6, p e902 (2023)
Externí odkaz:
https://doaj.org/article/e75def6293c04c28a72d3544a60120be
Autor:
Wei-Yu Lin, Sarah E. Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Tryfonia Mainou-Fowler, Rachel Piddock, Hannah Mearns, Timothy Barrow, Richard S. Houlston, Helen Marr, Jonathan Wallis, Geoffrey Summerfield, Scott Marshall, Andrew Pettitt, Christopher Pepper, Christopher Fegan, Francesco Forconi, Martin J. S. Dyer, Sandrine Jayne, April Sellors, Anna Schuh, Pauline Robbe, David Oscier, James Bailey, Syed Rais, Alison Bentley, Lynn Cawkwell, Paul Evans, Peter Hillmen, Guy Pratt, David J. Allsup, James M. Allan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with
Externí odkaz:
https://doaj.org/article/326c1d18f1cc498d8b36824ed27e2e04
Autor:
Louise de Schaetzen van Brienen, Maarten Larmuseau, Kim Van der Eecken, Frederic De Ryck, Pauline Robbe, Anna Schuh, Jan Fostier, Piet Ost, Kathleen Marchal
Publikováno v:
BMC Medical Genomics, Vol 13, Iss 1, Pp 1-15 (2020)
Abstract Background Research grade Fresh Frozen (FF) DNA material is not yet routinely collected in clinical practice. Many hospitals, however, collect and store Formalin Fixed Paraffin Embedded (FFPE) tumor samples. Consequently, the sample size of
Externí odkaz:
https://doaj.org/article/61fe339a87784c468a7027418ed2f036
Autor:
Tomasz K. Wojdacz, Harindra E. Amarasinghe, Latha Kadalayil, Alice Beattie, Jade Forster, Stuart J. Blakemore, Helen Parker, Dean Bryant, Marta Larrayoz, Ruth Clifford, Pauline Robbe, Zadie A. Davis, Monica Else, Dena R. Howard, Basile Stamatopoulos, Andrew J. Steele, Richard Rosenquist, Andrew Collins, Andrew R. Pettitt, Peter Hillmen, Christoph Plass, Anna Schuh, Daniel Catovsky, David G. Oscier, Matthew J.J. Rose-Zerilli, Christopher C. Oakes, Jonathan C. Strefford
Publikováno v:
Blood Advances, Vol 3, Iss 16, Pp 2474-2481 (2019)
Abstract: Chronic lymphocytic leukemia patients with mutated immunoglobulin heavy-chain genes (IGHV-M), particularly those lacking poor-risk genomic lesions, often respond well to chemoimmunotherapy (CIT). DNA methylation profiling can subdivide earl
Externí odkaz:
https://doaj.org/article/cd01b8a978aa4041a72a417cc4cb4fcc
Autor:
Anna Schuh, Hélène Dreau, Andreas Heger, David Sims, Fritz Offner, Bruno Verhasselt, Jan Philippé, André Efira, Virginie De Wilde, Marie Maerevoet, Radu Firescu, Philippe Mineur, Nathalie Meuleman, Peter Hillmen, David Bruce, Adele Timbs, Adam Burns, Pauline Robbe, Marek Mraz, Ruth Clifford, Karlien Pieters, Emerence Crompot, Thomas Smith, Basile Stamatopoulos
Supplementary Data Table S1: general characterisctic of the different cohorts of patients Supplementary Data Table S2: characterisctic of Population A Supplementary Data Table S3: characterisctic of Population B Supplementary Data Table S4: character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8b6261612d72e47a04ba5cab498fb5
https://doi.org/10.1158/1078-0432.22474745
https://doi.org/10.1158/1078-0432.22474745
Autor:
Anna Schuh, Hélène Dreau, Andreas Heger, David Sims, Fritz Offner, Bruno Verhasselt, Jan Philippé, André Efira, Virginie De Wilde, Marie Maerevoet, Radu Firescu, Philippe Mineur, Nathalie Meuleman, Peter Hillmen, David Bruce, Adele Timbs, Adam Burns, Pauline Robbe, Marek Mraz, Ruth Clifford, Karlien Pieters, Emerence Crompot, Thomas Smith, Basile Stamatopoulos
Purpose: Unmutated (UM) immunoglobulin heavy chain variable region (IgHV) status or IgHV3-21 gene usage is associated with poor prognosis in chronic lymphocytic leukemia (CLL) patients. Interestingly, IgHV3-21 is often co-expressed with light chain I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cdf1c245710e45d783276bd3991dd4
https://doi.org/10.1158/1078-0432.c.6528896.v1
https://doi.org/10.1158/1078-0432.c.6528896.v1
Autor:
Anna Schuh, Hélène Dreau, Andreas Heger, David Sims, Fritz Offner, Bruno Verhasselt, Jan Philippé, André Efira, Virginie De Wilde, Marie Maerevoet, Radu Firescu, Philippe Mineur, Nathalie Meuleman, Peter Hillmen, David Bruce, Adele Timbs, Adam Burns, Pauline Robbe, Marek Mraz, Ruth Clifford, Karlien Pieters, Emerence Crompot, Thomas Smith, Basile Stamatopoulos
Supplementary Data Figure S1. Determination of IgLV3-21 positivity by real-time PCR. Supplementary Data Figure S2: CLL-OS analysis including only CLL-related deaths. Supplementary Data Figure S3. Validation of the poor prognosis associated with IgLV3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c290abb945e53d972d785077c5b18f34
https://doi.org/10.1158/1078-0432.22474742
https://doi.org/10.1158/1078-0432.22474742
Autor:
Dylan Domenico, Gunes Gundem, Max F. Levine, Juanes E. Arango-Ossa, Pauline Robbe, Georgios Asimomitis, Cassidy Cobbs, Emily Stockfisch, Janine Senz, Dawn Cochrane, Neeman Mohibullah, Neerav Shukla, Sohrab P. Shah, Andrew McPherson, Anna Schuh, Andrew L. Kung, Elli Papaemmanuil
Publikováno v:
Cancer Research. 83:3142-3142
Whole genome sequencing (WGS) enables the identification of all cancer associated biomarkers in a patient’s tumor genome. Whilst fresh frozen (FF) derived WGS data provides optimal data quality, the majority of clinical biospecimens are from formal
Autor:
David John Allsup, Zoe Craig, David Cairns, Dena Howard, Anna Hockaday, Adrian Bloor, Zarni Soe, Christopher Pepper, Valter Gattei, Antonella Zucchetto, Pauline Robbe, Ruth Clifford, Anna Schuh, Talha Munir, Andrew Rawstron, Peter Hillmen
Publikováno v:
American Journal of Hematology. 97