Synthesis and Structure–Activity Relationship of Dehydrodieugenol B Neolignans against Trypanosoma cruzi

Autor: Andre G. Tempone, Maiara Amaral, Claire E. Sear, Joseph A. Tate, Marius M. Haugland, Maiara M. Romanelli, Edward A. Anderson, Thais A. Costa-Silva, João Henrique G. Lago, Pauline Pieper

Publikováno v: ACS Infectious Diseases

Trypanosoma cruzi is the etiologic agent of Chagas disease, which affects over seven million people, especially in developing countries. Undesirable side effects are frequently associated with current therapies, which are typically ineffective in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a839622c5ac80c9791ef933cc6427a
https://doi.org/10.1021/acsinfecdis.0c00523

Synthesis and Structure-Activity Relationship of Dehydrodieugenol B Neolignans against

Autor: Claire E, Sear, Pauline, Pieper, Maiara, Amaral, Maiara M, Romanelli, Thais A, Costa-Silva, Marius M, Haugland, Joseph A, Tate, João H G, Lago, Andre G, Tempone, Edward A, Anderson

Publikováno v: ACS Infectious Diseases

Trypanosoma cruzi is the etiologic agent of Chagas disease, which affects over seven million people, especially in developing countries. Undesirable side effects are frequently associated with current therapies, which are typically ineffective in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9d1edf67bb3e10b505ac94415f825a78
https://pubmed.ncbi.nlm.nih.gov/33047947

Liquid-Crystalline Tris[60]fullerodendrimers

Autor: Bertrand Donnio, Benoît Heinrich, Virginie Russo, Pauline Pieper, Robert Deschenaux

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2018, 83 (6), pp.3208-3219. ⟨10.1021/acs.joc.8b00093⟩

Liquid-crystalline tris[60]fullerodendrimers based on first- and second-generation poly(arylester)dendrons carrying cyanobiphenyl mesogens were synthesized for the first time by the olefin cross-metathesis reaction between type I (terminal) and type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cdcebc3589454e54f173278eb01b7e
https://hal.archives-ouvertes.fr/hal-02367754

Preparation of pillar[5]arene-based [2]rotaxanes by a stopper-exchange strategy

Autor: Michel Holler, Robert Deschenaux, Pauline Pieper, Jean-François Nierengarten, Eric Meichsner, Iwona Nierengarten, Béatrice Delavaux-Nicot

Publikováno v: Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2018, 24 (1), pp.169-177. ⟨10.1002/chem.201703997⟩

International audience; A pillar[5]arene-containing rotaxane building block bearing exchangeable stoppers has been prepared in multigram scale quantities with high yields from the reaction of 2,4-dinitrophenol (DNP) with the inclusion complex resulti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df243f5ee478f2247237a44e9c3f2da5
https://hal.archives-ouvertes.fr/hal-01957971

Enantioselective synthesis and anti-parasitic properties of aporphine natural products

Autor: Maiara Amaral, Eliza McHugh, Andre G. Tempone, Edward A. Anderson, Pauline Pieper

Publikováno v: Tetrahedron. 76:130814

Chagas disease and visceral leishmaniasis are neglected protozoan diseases with significant impact in developing countries. Due to the limited number and toxicity of current therapies, new drug leads are urgently needed. In this work, four aporphine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b782384e931e7e47754a661f5eb255
https://doi.org/10.1016/j.tet.2019.130814