Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Pauline, Mélénec"'
Autor:
Alessia Floerchinger, Kendelle J. Murphy, Sharissa L. Latham, Sean C. Warren, Andrew T. McCulloch, Young-Kyung Lee, Janett Stoehr, Pauline Mélénec, Cris S. Guaman, Xanthe L. Metcalf, Victoria Lee, Anaiis Zaratzian, Andrew Da Silva, Michael Tayao, Sonia Rolo, Monica Phimmachanh, Ghazal Sultani, Laura McDonald, Susan M. Mason, Nicola Ferrari, Lisa M. Ooms, Anna-Karin E. Johnsson, Heather J. Spence, Michael F. Olson, Laura M. Machesky, Owen J. Sansom, Jennifer P. Morton, Christina A. Mitchell, Michael S. Samuel, David R. Croucher, Heidi C.E. Welch, Karen Blyth, C. Elizabeth Caldon, David Herrmann, Kurt I. Anderson, Paul Timpson, Max Nobis
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109689- (2021)
Summary: Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Förster resonance energy transfer (
Externí odkaz:
https://doaj.org/article/60a7564e516e42fe894cc587d92fc98e
Autor:
Claire Vennin, Pauline Mélénec, Romain Rouet, Max Nobis, Aurélie S. Cazet, Kendelle J. Murphy, David Herrmann, Daniel A. Reed, Morghan C. Lucas, Sean C. Warren, Zehra Elgundi, Mark Pinese, Gabriella Kalna, Daniel Roden, Monisha Samuel, Anaiis Zaratzian, Shane T. Grey, Andrew Da Silva, Wilfred Leung, Australian Pancreatic Genome Initiative (APGI), Suresh Mathivanan, Yingxiao Wang, Anthony W. Braithwaite, Daniel Christ, Ales Benda, Ashleigh Parkin, Phoebe A. Phillips, John M. Whitelock, Anthony J. Gill, Owen J. Sansom, David R. Croucher, Benjamin L. Parker, Marina Pajic, Jennifer P. Morton, Thomas R. Cox, Paul Timpson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-22 (2019)
Subtypes of cancer associated fibroblasts can both promote and suppress tumorigenesis. Here, the authors investigate how p53 status in pancreatic cancer cells affects their interaction with cancer associated fibroblasts, and report perlecan as a medi
Externí odkaz:
https://doaj.org/article/9cbe7f002204495db0cd437d4360e24c
Autor:
James R.W. Conway, Sean C. Warren, David Herrmann, Kendelle J. Murphy, Aurélie S. Cazet, Claire Vennin, Robert F. Shearer, Monica J. Killen, Astrid Magenau, Pauline Mélénec, Mark Pinese, Max Nobis, Anaiis Zaratzian, Alice Boulghourjian, Andrew M. Da Silva, Gonzalo del Monte-Nieto, Arne S.A. Adam, Richard P. Harvey, Jody J. Haigh, Yingxiao Wang, David R. Croucher, Owen J. Sansom, Marina Pajic, C. Elizabeth Caldon, Jennifer P. Morton, Paul Timpson
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3312-3326 (2018)
Summary: Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to therapeutic inhibition of the PI3K pathway within the hypoxic microenvironment of pancre
Externí odkaz:
https://doaj.org/article/1dd7417190fc4a1586f84ed7e4b76935
Autor:
James R. W. Conway, Sean C. Warren, Young-Kyung Lee, Andrew T. McCulloch, Astrid Magenau, Victoria Lee, Xanthe L. Metcalf, Janett Stoehr, Katharina Haigh, Lea Abdulkhalek, Cristian S. Guaman, Daniel A. Reed, Kendelle J. Murphy, Brooke A. Pereira, Pauline Mélénec, Cecilia Chambers, Sharissa L. Latham, Helen Lenthall, Elissa K. Deenick, Yuanqing Ma, Tri Phan, Elgene Lim, Anthony M. Joshua, Stacey Walters, Shane T. Grey, Yan-Chuan Shi, Lei Zhang, Herbert Herzog, David R. Croucher, Andy Philp, Colinda L.G.J. Scheele, David Herrmann, Owen J. Sansom, Jennifer P. Morton, Antonella Papa, Jody J. Haigh, Max Nobis, Paul Timpson
Publikováno v:
Science Advances. 9
Aberrant AKT activation occurs in a number of cancers, metabolic syndrome, and immune disorders, making it an important target for the treatment of many diseases. To monitor spatial and temporal AKT activity in a live setting, we generated an Akt-FRE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6f9949213693722c610a68b2040bc6
https://doi.org/10.1126/sciadv.adf9063
https://doi.org/10.1126/sciadv.adf9063
Autor:
Sean C Warren, Max Nobis, Astrid Magenau, Yousuf H Mohammed, David Herrmann, Imogen Moran, Claire Vennin, James RW Conway, Pauline Mélénec, Thomas R Cox, Yingxiao Wang, Jennifer P Morton, Heidi CE Welch, Douglas Strathdee, Kurt I Anderson, Tri Giang Phan, Michael S Roberts, Paul Timpson
Publikováno v:
eLife, Vol 7 (2018)
Intravital microscopy can provide unique insights into the function of biological processes in a native context. However, physiological motion caused by peristalsis, respiration and the heartbeat can present a significant challenge, particularly for
Externí odkaz:
https://doaj.org/article/b19ab0cf001841f7a2cef5cafceef00f
Autor:
Pierre Recouvreux, Pritha Pai, Rémy Torro, Mónika Ludányi, Pauline Mélénec, Mariem Boughzala, Vincent Bertrand, Pierre-François Lenne
Different signaling mechanisms concur to ensure robust tissue patterning and cell fate instruction during animal development. Most of these mechanisms rely on signaling proteins that are produced, transported and detected. The spatiotemporal dynamics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f90e52fafc5f490c89a6f763662458b
https://doi.org/10.1101/2023.01.17.524363
https://doi.org/10.1101/2023.01.17.524363
Autor:
Laura M. Machesky, Sharissa L. Latham, Karen Blyth, Owen J. Sansom, Paul Timpson, Cris S. Guaman, Victoria Lee, Nicola Ferrari, Anaiis Zaratzian, Sean C. Warren, Susan M. Mason, Pauline Mélénec, Lisa M Ooms, C. Elizabeth Caldon, Andrew M. Da Silva, Andrew T. McCulloch, Michael F. Olson, Xanthe L. Metcalf, Ghazal Sultani, Monica Phimmachanh, David Herrmann, Michael Tayao, Max Nobis, Alessia Floerchinger, Janett Stoehr, Jennifer P. Morton, Anna-Karin E. Johnsson, Christina Anne Mitchell, Heather J. Spence, Kendelle J. Murphy, David R. Croucher, Sonia Rolo, Heidi C.E. Welch, Young-Kyung Lee, Michael S. Samuel, Laura McDonald, Kurt I. Anderson
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109689-(2021)
Assessing drug response within live native tissue provides increased fidelity with regards to optimizing efficacy while minimizing off-target effects. Here, using longitudinal intravital imaging of a Rac1-Forster resonance energy transfer (FRET) bios
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e60a0a238c9fea39f12263962e274fc
Autor:
Robert F. Shearer, Paul Timpson, Pauline Mélénec, Kendelle J. Murphy, Mark Pinese, David R. Croucher, Aurélie Cazet, Arne S.A. Adam, Anaiis Zaratzian, C. Elizabeth Caldon, Yingxiao Wang, Jody J. Haigh, Richard P. Harvey, Alice Boulghourjian, Gonzalo del Monte-Nieto, Claire Vennin, Marina Pajic, Owen J. Sansom, Andrew M. Da Silva, David Herrmann, James R.W. Conway, Sean C. Warren, Monica J. Killen, Jennifer P. Morton, Astrid Magenau, Max Nobis
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3312-3326 (2018)
Cell Reports
Cell Reports
Summary Application of advanced intravital imaging facilitates dynamic monitoring of pathway activity upon therapeutic inhibition. Here, we assess resistance to therapeutic inhibition of the PI3K pathway within the hypoxic microenvironment of pancrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1063f908dc8ede516a732e6fc6596ce1
http://www.sciencedirect.com/science/article/pii/S2211124718307848
http://www.sciencedirect.com/science/article/pii/S2211124718307848
Autor:
Pauline Mélénec, Guillaume Bordet, Sabrina Murgan, Vincent Bertrand, Shilpa Kaur, Pierre-François Lenne, Pierre Recouvreux
Publikováno v:
Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2020, 147 (7), pp.dev183186. ⟨10.1242/dev.183186⟩
Development (Cambridge, England), 2020, 147 (7), pp.dev183186. ⟨10.1242/dev.183186⟩
Development (Cambridge, England), Company of Biologists, 2020, 147 (7), pp.dev183186. ⟨10.1242/dev.183186⟩
Development (Cambridge, England), 2020, 147 (7), pp.dev183186. ⟨10.1242/dev.183186⟩
International audience; Wnt/β-catenin signalling has been implicated in the terminal asymmetric divisions of neuronal progenitors in vertebrates and invertebrates. However, the role of Wnt ligands in this process remains poorly characterized. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c19ba2156c0d3e12c43236ef518715
https://hal.archives-ouvertes.fr/hal-02908266
https://hal.archives-ouvertes.fr/hal-02908266
Autor:
Shilpa, Kaur, Pauline, Mélénec, Sabrina, Murgan, Guillaume, Bordet, Pierre, Recouvreux, Pierre-François, Lenne, Vincent, Bertrand
Publikováno v:
Development (Cambridge, England). 147(7)
Wnt/β-catenin signalling has been implicated in the terminal asymmetric divisions of neuronal progenitors in vertebrates and invertebrates. However, the role of Wnt ligands in this process remains poorly characterized. Here, we used the terminal div
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03f1f7087d85d7767387324044c8c852
https://pubmed.ncbi.nlm.nih.gov/32156756
https://pubmed.ncbi.nlm.nih.gov/32156756